pharmaphorum

MAY 16, 2022

GLP-1 and GIP are hormones involved in blood sugar control and Mounjaro, a first-in-class medicine that activates both GLP-1 and GIP receptors, demonstrated improved blood sugar control. It was also compared to a placebo, a GLP-1 receptor agonist (semaglutide) and two long-acting insulin analogues. more than insulin degludec and 1.0%

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Scienmag

SEPTEMBER 13, 2021

Philadelphia, September 13, 2021—Researchers at Children’s Hospital of Philadelphia (CHOP) have demonstrated that an experimental device can improve blood sugar control in patients who developed diabetes after their pancreas was removed to treat their hyperinsulinism, a genetic disease in which the pancreas produces too much insulin.

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The Pharma Data

SEPTEMBER 30, 2021

Lilly’s Insulin Lispro Injection, 100 units/mL — first introduced at half the list price of branded Humalog® (insulin lispro injection, 100 units/mL) in 2019 — will now have a 70 percent lower list price than Humalog U-100 starting January 1, 2022 Insulin Lispro Injection can be ordered through all U.S.

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XTalks

JULY 17, 2024

Sweden-based biotech Camurus shared positive Phase III trial data for CAM2029, one of its lead candidates, in patients with the rare hormonal disorder acromegaly. Octreotide is a synthetic analog of somatostatin, a hormone in the body that inhibits the release of several other hormones, including growth hormone (GH), glucagon and insulin.

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Trials Hormones Clinical Trials Clinical Trials 59

XTalks

DECEMBER 13, 2024

Petrelintide, administered once a week under the skin, targets obesity through its action as an amylin analog, a hormone co-secreted with insulin from the pancreas. By mimicking this hormone, petrelintide may offer an alternative or complement to incretin-based therapies, known for their role in weight management.

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Drugs Hormones Trials Clinical Trials 102

The Pharma Data

JUNE 28, 2021

In honor of the 100th anniversary of the discovery of insulin, Eli Lilly and Company (NYSE: LLY) today launched the Leonard Award to recognize diverse champions dedicated to advancing diabetes management through innovative thinking and novel approaches. Nominations are being accepted now until August 31, 2021 at Lilly.com/LeonardAward.

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Pharmaceutical Technology

MARCH 23, 2023

While lifestyle modifications play a key role in treating PCOS, the paucity of new treatments signal a need for breakthrough research. Research states that PCOS is typically characterized by hyperandrogenism, high levels of androgens; ovulatory dysfunction; and polycystic ovaries.

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Development Insulin Hormones Research 130

The Pharma Data

MAY 6, 2021

The Tempo Pen is a modified version of Lilly ‘s existing prefilled, disposable insulin pen to which the Tempo Smart Button – pending CE (Conformité Européenne or European Conformity) marking – attaches. Diabetes is a chronic disease that occurs when the body does not properly produce or use the hormone insulin.

Insulin 52

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The Pharma Data

FEBRUARY 25, 2021

and Eli Lilly and Company (NYSE: LLY) announced today a collaboration and licensing agreement to integrate Welldoc’s software into Lilly’s connected insulin solutions, currently in development. Lilly will commercialize the pen platform, which will include the new app and Lilly’s connected insulin pen solutions.

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Insulin Medicine Hormones Development 40

Velocity Clinical Research

JUNE 27, 2023

The prolific researchers also had findings simultaneously published in the New England Journal of Medicine and The Lancet. Dr. Rosenstock is the lead investigator for Novo Nordisk’s ONWARDS 1 program exploring the first investigational once-weekly insulin. “In Trial results were presented at the ADA sessions and published in NEJM.

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The Pharma Data

DECEMBER 17, 2020

7, 2020 — After starting a drug that’s officially approved to treat a type of blood cancer, a young man with type 1 diabetes was able to stop using insulin. He’s been off insulin since August 2018 — more than two years. But more research is needed, she added. WEDNESDAY, Oct. ” © 2020 HealthDay.

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The Pharma Data

NOVEMBER 2, 2020

That’s one finding from an early study that tested the injection drug, which mimics the effects of a natural hormone called fibroblast growth factor 21 (FGF21). Researchers found that a single injection spurred “metabolic improvements” in overweight and obese adults that lasted up to two months.

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XTalks

NOVEMBER 3, 2022

Mounjaro was approved this summer as a Type 2 diabetes treatment and is the first diabetes drug with dual action, targeting two hormones involved in insulin production and appetite (GIP and GLP-1). In contrast, Novo’s diabetes drugs Ozempic and Rybelsus (both semaglutide) are just GLP-1 agonists.

Sales 98

Sales FDA Approval Production Insulin 98

XTalks

APRIL 29, 2022

Tirzepatide is a novel investigational obesity treatment that contains mimetics of two hormones that are involved in regulating appetite in a single peptide: a GIP (glucose-dependent insulinotropic polypeptide) receptor agonist and a GLP-1 (glucagon-like peptide-1) receptor agonist.

Trials 98

Trials Drugs FDA Approval Clinical Trials 98

XTalks

SEPTEMBER 28, 2023

While the FDA believes the levels of titanium dioxide in US food are safe, the International Agency for Research on Cancer categorizes it as a Group 2B carcinogen , indicating a potential risk to humans if inhaled. There’s been varied research regarding the synthetic hormone’s association with breast cancer.

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XTalks

SEPTEMBER 17, 2020

While clinical researchers occasionally need to identify and validate a new surrogate endpoint for a given trial, choosing endpoints that have been previously used as the basis of NDAs and BLAs can clear the path to eventual approval. Symptoms and Etiology: Caused by an overproduction of growth hormone, acromegaly primarily affects adults.

Trials 98

Trials Gene Hormones Clinical Trials 98

pharmaphorum

JULY 28, 2022

The RNA interference specialist says its researchers and collaborators have identified mutations in a gene called INHBE that are associated with protection against abdominal obesity and metabolic syndrome – a condition impacting more than 20% of adults worldwide.

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Biobanking Gene Gene Silencing Drugs 52

XTalks

FEBRUARY 21, 2024

Tirzepatide’s mechanism of action involves activating two naturally produced hormones: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Similar to tirzepatide, dulaglutide stimulates insulin secretion, inhibits glucagon release and promotes satiety.

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Clinical Trials Clinical Trials Trials Insulin 59

XTalks

OCTOBER 11, 2023

They mimic the action of GLP-1, a hormone that helps regulate blood sugar levels by enhancing insulin secretion. There was also a high rate of biliary disease in patients taking either liraglutide or semaglutide, but the researchers said the difference was “not found to be statistically significant.”

Drugs 59

Drugs Insulin Hormones FDA Approval 59

The Pharma Data

JANUARY 19, 2021

19, 2021 — Tough limits on carbohydrates in your meals can help get type 2 diabetes under control — but the benefits typically wane over time, a new research review shows. It’s not clear why, according to Grant Brinkworth, one of the researchers on the review. TUESDAY, Jan. Centers for Disease Control and Prevention.

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The Pharma Data

NOVEMBER 11, 2021

Moment Eli Lilly and Company (NYSE LLY) blazoned the five winners of the initial Leonard Award, which commemorates the 100th anniversary of the discovery of insulin by feting different titleholders devoted to advancing diabetes operation. Amalia Gastaldelli, Research Director, Institute of Clinical Physiology, CNR.

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Insulin Drugs Hormones Medicine 40

Delveinsight

DECEMBER 7, 2020

The device is worn on the patients’ body, which contains a biharmonic cartridge in it that carries insulin and glucagon. The device can be configured to inject a specific dose of the hormones into the patient. The device is expected to become a game-changer in diabetes and congenital hyperinsulinism disease areas.

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Protein Insulin Development Hormones 56

pharmaphorum

APRIL 1, 2022

Semglee (insulin glargine-yfgn) is the first biosimilar available at the retail pharmacy counter, and it obtained interchangeable status. As such, manufacturers—some we have seen before and some new to biosimilars—will likely look to enter into existing and new therapeutic areas, including ophthalmology and the growth hormone space.

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The Pharma Data

JUNE 28, 2021

Medical Director, National Research Institute and Principal Investigator of SURPASS-2. GIP is a hormone that may complement the effects of GLP-1. Diabetes is a chronic disease that occurs when the body does not properly produce or use the hormone insulin.

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Clinical Trials Clinical Trials Insulin Hormones 52

Roots Analysis

JANUARY 23, 2024

The peptide therapeutics market has undergone substantial evolution since the inception of insulin. I, recently, worked on a market research report, title Peptide Synthesis Market , Till 2035. During research, I could identify over 75 peptide synthesis companies that offer peptide synthesis services.

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Development Contract Manufacturing Drugs Manufacturing 40

pharmaphorum

APRIL 13, 2022

The treatment has been around for over a century but insulin has still become the centre of the ongoing discussion over pricing of pharmaceutical products. Ben Hargreaves looks at why insulin’s price is so controversial and whether this could be set to change. Insulin rationing. In the US, approximately 37.3

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Insulin Drugs Production Hormones 130

The Pharma Data

MARCH 5, 2021

Medical Director, National Research Institute and Principal Investigator of SURPASS-2. GIP is a hormone that may complement the effects of GLP-1 receptor agonists. Diabetes is a chronic disease that occurs when the body does not properly produce or use the hormone insulin. Source link:[link].

Clinical Trials 52

Clinical Trials Clinical Trials Trials Hormones 52

The Pharma Data

JUNE 28, 2021

Director of the Dallas Diabetes Research Center at Medical City and Principal Investigator of SURPASS-1. GIP is a hormone that may complement the effects of GLP-1. Diabetes is a chronic disease that occurs when the body does not properly produce or use the hormone insulin. Source link: [link].

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Clinical Trials Clinical Trials Trials Hormones 40

XTalks

NOVEMBER 21, 2024

These gut hormones are released in response to nutrient intake and play a crucial role in the incretin effect, which enhances insulin secretion. Researchers monitored a range of health metrics, including fasting glucose, HbA1c levels and weight changes.

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Sales Insulin Drugs Trials 105

XTalks

FEBRUARY 9, 2021

In the November study published in Diabetes, Obesity and Metabolism , researchers performed a meta-analysis of observational studies with data on the number or proportion of COVID?19 Researchers found that more than one in ten COVID-19 patients (14.4 The analysis consisted of 3,711 patients across eight different studies.

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Insulin Immune Response Hormones Research 105

The Pharma Data

AUGUST 17, 2021

approval of pump use for Lilly’s novel insulin is latest development designed to help people with diabetes manage blood sugar levels. Lyumjev, a novel formulation of insulin lispro developed to speed the absorption of insulin into the bloodstream and reduce A1C levels, was approved by the FDA in June 2020.

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Insulin FDA Approval Doctors Doctor 52

The Pharma Data

DECEMBER 14, 2020

14, 2020 — It could be more than just added calories: New research gives insight into why sugary drinks are a leading cause of obesity. adults, and researchers now report that the drinks also hinder hormones that quell hunger and regulate appetite. MONDAY, Dec. The study was published Dec. © 2020 HealthDay.

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Camargo

NOVEMBER 29, 2021

They may contain proteins that control the action of other proteins and cellular processes, genes that control production of vital proteins, modified human hormones, or cells that produce substances that suppress or activate components of the immune system. Biologics include a wide range of products , including: Vaccines. Allergenics.

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Development Protein Production Hormones 180

The Pharma Data

NOVEMBER 20, 2020

20, 2020 — Hormone therapy can be a lifesaver for men with prostate cancer , but it also appears to put some at increased risk of heart problems, a new study reports. “Our data are not suggesting that androgen deprivation therapy definitely causes worse heart health,” said lead researcher Dr. . FRIDAY, Nov.

Hormones 52

Hormones Insulin Research Doctors 52

XTalks

JUNE 10, 2024

Efruxifermin is a novel Fc-FGF21 fusion protein designed to emulate the activity of native FGF21, an endogenous hormone that regulates metabolism and alleviates cellular stress. Research indicates that approximately 34 percent of individuals with obesity are also affected by MASH.

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Insulin Life Science Regulation Hormones 52

Roots Analysis

SEPTEMBER 9, 2024

In addition, other industries, such as agriculture, cosmetics, food, environmental sciences, biomedical research and enzyme synthesis industry, are also benefiting from the protein expression process. Author’s Bio Akarshika Singh is a business research analyst and competitive intelligence professional.

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Protein Gene Production DNA 40

Delveinsight

DECEMBER 29, 2020

Relugolix is a once-daily, oral gonadotropin-release hormone (GnRH) receptor antagonist. It is a complication associated with diabetic patients who take insulin and certain anti-diabetic tablets. To overcome this, Glucagon, a hormone in the body, helps the liver to quickly increase blood sugar levels. mg) in the US and Canada.

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Trials Drugs Hormones Radiology 52