Pharmaceutical Technology

SEPTEMBER 26, 2022

The 'life-extending' drug combination is recommended for usage in adult patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) breast cancer who have previously received hormone therapy. It acts by hindering proteins in cancer cells to avert cell division and growth.

HR 130

HR Drugs Hormones Medicine 130

XTalks

NOVEMBER 26, 2020

In addition to innovative new antibody drugs and mRNA vaccines, researchers have found that the sleep-regulating hormone melatonin may also offer protection against COVID-19. The study was published in the journal PLOS Biology. Related: Can Vitamin D Be Beneficial for COVID-19 Patients?

Research 98

Research Hormones Protein Regulation 98

Pharmaceutical Technology

MAY 31, 2023

The therapeutic candidate targets immune checkpoint, programmed cell death protein 1 (PD1). The company’s portfolio of marketed products treats central nervous system (CNS) disorders, cardiovascular diseases, cancer, ENT disorders, respiratory diseases, hematological disorders, hormonal disorders, and others.

Generic Drugs 100

Generic Drugs Hormones Manufacturing Development 100

Scienmag

SEPTEMBER 15, 2020

Researchers develop a wider spectrum for dLight1 sensor, allowing multiplex imaging of neurotransmitters Credit: UC Regents Sacramento, CA– In 2018, Lin Tian and her team at UC Davis Health developed dLight1, a single fluorescent protein-based biosensor.

Hormones 55

Hormones Protein Development Research 55

Pharmaceutical Technology

FEBRUARY 14, 2023

Alkaloids, natural dyes, drugs, proteins, and enzymes are some of the important classes of natural heterocyclic compounds essential for human life. The company filed heterocyclic composition patents in areas such as PAD4 inhibitors, factor Xa inhibitors, and nuclear hormone receptor modulators.

Antibody 130

Antibody Hormones DNA Licensing 130

The Pharma Data

DECEMBER 9, 2020

The trial, conducted in nine countries, found that adding chemotherapy to hormone-blocking drugs brought no added benefit to a particular group of patients. Those were postmenopausal women with hormone-sensitive breast cancer that had spread to only one to three lymph nodes, and who had a low risk of recurrence. WEDNESDAY, Dec.

Hormones 52

Hormones Trials Medicine Research 52

Delveinsight

JULY 30, 2020

Adrenoleukodystrophy (ALD/ X-ALD) is a rare, X-linked disorder secondary to a mutation in the ABCD1 gene, which encodes for a peroxisomal membrane protein, resulting in an excessive accumulation of very-long-chain fatty acids (VLCFAs) in the brain and adrenal glands. The disorder can occur at any stage of life and vary with severity.

Hormones 52

Hormones Marketing Gene Trials 52

The Pharma Data

JANUARY 7, 2021

However, Sanofi’s programs have significant depth below the waterline that could result in the approval of important medicines to treat difficult diseases. He also noted innovations are occurring with protein degraders, antibody conjugates, nanobodies and multi-specific antibodies, specifically bi- and tri-specific.

Protein 52

Protein Antibody Genetics Gene Therapy 52

Pfizer

AUGUST 15, 2022

Current variants of concern can be resistant to treatments that work by binding to the spike protein found on the surface of the SARS-CoV-2 virus. Microsomal triglyceride transfer protein inhibitor: lomitapide. Contraception : Use of ritonavir may reduce the efficacy of combined hormonal contraceptives. COVID-19, Vaccines.

Drugs 99

Drugs Vaccination Vaccine In-Vitro 99

XTalks

FEBRUARY 7, 2023

Current treatments for HR+ breast cancer patients include hormonal therapies, chemotherapies for those that do not respond to hormonal therapy alone and targeted therapies, either stand-alone or in combination with hormonal therapies. What does this Approval Mean for Breast Cancer Patients?

HR 52

HR Hormones FDA Approval Antibody 52

Roots Analysis

OCTOBER 24, 2023

Owing to the advancement in clinical pharmacology and oncology domain, and the rising demand for targeted therapeutics and precision medicines, high potency active pharmaceutical ingredients (HPAPIs) and cytotoxic drugs have become one of the key areas of interest to researchers and drug manufacturers across the globe.

Manufacturing 40

Manufacturing Hormones Contamination Containment 40

Pfizer

DECEMBER 13, 2022

Current variants of concern can be resistant to treatments that work by binding to the spike protein found on the surface of the SARS-CoV-2 virus. Microsomal triglyceride transfer protein inhibitor: lomitapide. Contraception: Use of ritonavir may reduce the efficacy of combined hormonal contraceptives. COVID-19 Medicines.

Drugs 110

Drugs Licensing Licensing Production 110

Pfizer

JANUARY 27, 2023

Working with collaborators, we have conducted research where the original SARS-CoV-2 virus has been used to express the spike protein from new variants of concern. Contraception: Use of ritonavir may reduce the efficacy of combined hormonal contraceptives.

Research 112

Research Vaccine Vaccination Drugs 112

The Pharma Data

APRIL 27, 2022

The Food and Drug Administration’s (FDA) BTD is designed to accelerate the development and regulatory review of potential new medicines that are intended to treat a serious condition and address a significant unmet medical need. 1-4 Low HER2 expression occurs in both HR-positive and HR-negative disease.

HR 52

HR Trials Protein Medicine 52

XTalks

JUNE 10, 2024

Efruxifermin is a novel Fc-FGF21 fusion protein designed to emulate the activity of native FGF21, an endogenous hormone that regulates metabolism and alleviates cellular stress. It can lead to inflammation, fibrosis, cirrhosis, liver failure and potentially death.

Insulin 52

Insulin Life Science Regulation Hormones 52

The Pharma Data

SEPTEMBER 16, 2020

Blueprint Medicines will present new data from the registrational phase I/II ARROW trial, investigating Gavreto TM (pralsetinib) for the treatment of people with RET-mutant medullary thyroid cancer. Gavreto is being jointly commercialised by Genentech, a wholly owned member of the Roche Group, and Blueprint Medicines in the U.S.

HR 52

HR Medicine Hormones Trials 52

Pfizer

JANUARY 27, 2023

Current variants of concern can be resistant to treatments that work by binding to the spike protein found on the surface of the SARS-CoV-2 virus. Contraception: Use of ritonavir may reduce the efficacy of combined hormonal contraceptives. In preclinical studies, nirmatrelvir did not demonstrate evidence of mutagenic DNA interactions.

Marketing 75

Marketing Production Drugs Licensing 75

The Pharma Data

JANUARY 27, 2021

These include in-vitro assays, cell-based phenotypic assays, safety pharmacology and efficacy, ADME toxicology, medicinal chemistry design, synthetic chemistry, and custom proteins and assay development capabilities.

In-Vitro 52

In-Vitro Containment Drugs Production 52

The Pharma Data

MAY 14, 2021

Metabolic Breakthrough Rebalances Your “Hot Zone Hormones” So Any Woman Over 35 Can Blast Off Belly Fat, Shape Flabby Muscle And See Your Most Attractive,Youthful, And Energized Body Ever In Only 30 Days WITHOUT Suffering Through Restrictive Diets Or Trying To Starve Yourself Skinny. Helping you Permanently Blast off Belly Fat.

Protein 52

Protein Production Hormones Vaccination 52

XTalks

DECEMBER 22, 2021

RNA, and its protein-generating form messenger RNA (mRNA) discovered in 1961 , has quickly transitioned from being an obscure, finicky molecule that is difficult to work with, to becoming a significant cornerstone of therapeutic innovation in pharma and biotech. The RNA Revolution: From mRNA Vaccines to RNA Editing.

Life Science 98

Life Science RNA Vaccine Vaccination 98

Pfizer

DECEMBER 20, 2022

The extension of the NDA review period will not impact the Emergency Use Authorization (EUA) or the current availability of the medicine for eligible patients. Current variants of concern can be resistant to treatments that work by binding to the spike protein found on the surface of the SARS-CoV-2 virus. In the U.S., approximately 7.6

Drugs 69

Drugs Licensing Licensing Containment 69

Velocity Clinical Research

JUNE 27, 2023

The prolific researchers also had findings simultaneously published in the New England Journal of Medicine and The Lancet. “It’s a chemical, a small molecule that also acts on the GLP-1 receptor, but because it’s not a protein it’s not degraded by enzymes,” said Dr. Frias.

Insulin 52

Insulin Trials Hormones Clinical Trials 52

The Pharma Data

MAY 15, 2021

Page 311 – Knowing how keeping your body’s PH level normalized is your key to preventing most diseases (cardiovascular, diabetes, cancer, hormone imbalance, immune deficiency, kidney problems, headaches, etc.). Learn a simple method to test your body’s PH level and how you can easily keep it within safe levels.

Doctor 52

Doctor Doctors Containment Allergies 52

Roots Analysis

JANUARY 23, 2024

They also play important roles in antibiotics , toxins, hormones, and enzymes. These versatile molecules serve various diverse roles, functioning as neurotransmitters, growth factors, ion channel ligands, hormones, anti-infectives, and more. When introduced into the body, lab-synthesized peptides become active.

Development 40

Development Contract Manufacturing Drugs Manufacturing 40

The Pharma Data

FEBRUARY 8, 2021

Metastatic castration-sensitive prostate cancer, also known as metastatic hormone-sensitive prostate cancer (mHSPC), refers to prostate cancer that still responds to hormonal therapy and has spread beyond the prostate to other parts of the body. [4]. New England Journal of Medicine. About ERLEADA ® (apalutamide). 3] Chi, K.

HR 52

HR Hormones Development Production 52

The Pharma Data

JANUARY 10, 2021

We expect to further advance our late stage endocrinology pipeline with the anticipated approval and launch in the United States and the approval in Europe of TransCon hGH for pediatric growth hormone deficiency, and to obtain phase 3 results for TransCon PTH in adult hypoparathyroidism. ?. . .

Hormones 40

Hormones Clinical Development Clinical Trials Clinical Trials 40

The Pharma Data

MAY 15, 2021

SLIM OVER 55 is THE ONLY program for women over 55 that is especially designed for your body who has gone through menopause and needs to get all the hormones back in balance! Each of the Slim Over 55 meals are perfectly balanced with precise nutrients, carbohydrates, proteins, vitamins and the healthiest of fats.

Production 52

Production Sales Hormones Vaccination 52

The Pharma Data

JUNE 18, 2021

lead study investigator of the Phase 3 RESONATE-2 trial, and Professor of Medicine at the Wilmot Cancer Institute, University of Rochester. The BTK protein sends important signals that tell B cells to mature and produce antibodies. IMBRUVICA ® is the only FDA-approved medicine in WM and cGVHD. Barr , M.D., Taking IMBRUVICA ® ?with

FDA Approval 40

FDA Approval Medicine Development Trials 40

The Pharma Data

MAY 16, 2021

She goes further to teach you things like how to get out of or avoid plateaus, and even how to manipulate your own hormone production for better, and desirable biological responses. In her book Karen teaches you nutrition, resistance training, resting, supplementation. And it doesn’t stop there. ” Ivan Nikolov.

Production 52

Production Hormones Genetics Vaccination 52

The Pharma Data

MAY 16, 2021

And, most importantly, your body doesn’t get enough protein. Protein contains essential amino acids which are vital for supporting your body and muscle growth. Sure, you drop weight within days and weeks of starving yourself but who wouldn’t, right? To continue dropping fat, you have to starve yourself even more.

Production 52

Production Containment Hormones Vaccination 52

The Pharma Data

AUGUST 11, 2020

We are developing cancer treatments directed at key biological pathways using our protein homeostasis platform, a research capability that has been the basis of our approved therapies for multiple myeloma and several promising compounds in early- to mid-stage development. Administer hormone-replacement therapy for hypothyroidism.

Trials 52

Trials Hormones Clinical Trials Clinical Trials 52

XTalks

AUGUST 2, 2023

With each passing year, pharmaceutical companies around the globe strive to deliver cutting-edge medicines, therapies and vaccines that impact the lives of millions. In this in-depth article, we embark on a captivating journey to uncover the top 30 pharma and biotech companies that have been instrumental in shaping the future of medicine.

Sales 98

Sales Manufacturing FDA Approval Life Science 98

The Pharma Data

AUGUST 11, 2020

We are developing cancer treatments directed at key biological pathways using our protein homeostasis platform, a research capability that has been the basis of our approved therapies for multiple myeloma and several promising compounds in early- to mid-stage development. Administer hormone-replacement therapy for hypothyroidism.

Trials 52

Trials Hormones Clinical Trials Clinical Trials 52

The Pharma Data

FEBRUARY 8, 2021

Hypothyroidism — In 2 randomized studies, hypothyroidism was reported for 8% of patients treated with ERLEADA ® and 2% of patients treated with placebo based on assessments of thyroid-stimulating hormone (TSH) every 4 months. The safety profile was consistent with prior studies of ERLEADA ® , with no new safety signals observed.

HR 52

HR In-Vitro Development Clinical Trials 52

The Pharma Data

MARCH 17, 2021

In estrogen receptor-positive (ER+) breast cancer cell lines, cyclin D1 and CDK4 & 6 promote phosphorylation of the retinoblastoma protein (Rb), cell cycle progression, and cell proliferation. Verzenio (abemaciclib) is an inhibitor of cyclin-dependent kinases (CDK)4 & 6, which are activated by binding to D-cyclins.

HR 52

HR Trials In-Vitro Manufacturing 52

The Pharma Data

MAY 14, 2021

Your body’s hormones are destroyed from almost a year of starvation. There are so many people out there telling you to try keto, intermittent fasting, vegan, high-protein, high-fat, low-fat, and so much more. I promised her I would do it, no matter how difficult, and for the next few months, I would work with her every single week.

Production 52

Production Branding Vaccination Vaccine 52

The Pharma Data

FEBRUARY 1, 2021

1, 2021 (American Heart Association News) — Medical science has come a long way since the days of “bikini medicine,” when the only time doctors managed a woman’s health differently than a man’s was when treating the parts of her body found under a bikini. MONDAY, Feb. It’s that they age differently.

Hormones 40

Hormones Radiology Research Medicine 40