Scienmag

SEPTEMBER 15, 2020

Researchers develop a wider spectrum for dLight1 sensor, allowing multiplex imaging of neurotransmitters Credit: UC Regents Sacramento, CA– In 2018, Lin Tian and her team at UC Davis Health developed dLight1, a single fluorescent protein-based biosensor.

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The Pharma Data

DECEMBER 9, 2020

The trial, conducted in nine countries, found that adding chemotherapy to hormone-blocking drugs brought no added benefit to a particular group of patients. Those were postmenopausal women with hormone-sensitive breast cancer that had spread to only one to three lymph nodes, and who had a low risk of recurrence. WEDNESDAY, Dec.

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Delveinsight

JULY 30, 2020

Adrenoleukodystrophy (ALD/ X-ALD) is a rare, X-linked disorder secondary to a mutation in the ABCD1 gene, which encodes for a peroxisomal membrane protein, resulting in an excessive accumulation of very-long-chain fatty acids (VLCFAs) in the brain and adrenal glands. The disorder can occur at any stage of life and vary with severity.

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The Pharma Data

JANUARY 7, 2021

However, Sanofi’s programs have significant depth below the waterline that could result in the approval of important medicines to treat difficult diseases. He also noted innovations are occurring with protein degraders, antibody conjugates, nanobodies and multi-specific antibodies, specifically bi- and tri-specific.

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Roots Analysis

OCTOBER 24, 2023

Owing to the advancement in clinical pharmacology and oncology domain, and the rising demand for targeted therapeutics and precision medicines, high potency active pharmaceutical ingredients (HPAPIs) and cytotoxic drugs have become one of the key areas of interest to researchers and drug manufacturers across the globe.

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The Pharma Data

AUGUST 6, 2020

Safety for the Tecentriq combination appeared to be consistent with the known safety profile of the individual medicines, and no new safety signals were identified. This includes studies evaluating Tecentriq both alone and in combination with other medicines. By inhibiting PD-L1, Tecentriq may enable the activation of T-cells.

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The Pharma Data

JANUARY 27, 2021

These include in-vitro assays, cell-based phenotypic assays, safety pharmacology and efficacy, ADME toxicology, medicinal chemistry design, synthetic chemistry, and custom proteins and assay development capabilities.

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Velocity Clinical Research

JUNE 27, 2023

The prolific researchers also had findings simultaneously published in the New England Journal of Medicine and The Lancet. “It’s a chemical, a small molecule that also acts on the GLP-1 receptor, but because it’s not a protein it’s not degraded by enzymes,” said Dr. Frias.

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The Pharma Data

SEPTEMBER 19, 2020

This includes studies evaluating Tecentriq both alone and in combination with other medicines. Our medicines, along with companion diagnostic tests, have contributed to bringing breakthrough innovations in HER2-positive and triple negative breast cancers. By inhibiting PD-L1, Tecentriq may enable the activation of T-cells.

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Roots Analysis

JANUARY 23, 2024

They also play important roles in antibiotics , toxins, hormones, and enzymes. These versatile molecules serve various diverse roles, functioning as neurotransmitters, growth factors, ion channel ligands, hormones, anti-infectives, and more. When introduced into the body, lab-synthesized peptides become active.

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The Pharma Data

JANUARY 10, 2021

We expect to further advance our late stage endocrinology pipeline with the anticipated approval and launch in the United States and the approval in Europe of TransCon hGH for pediatric growth hormone deficiency, and to obtain phase 3 results for TransCon PTH in adult hypoparathyroidism. ?. . .

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Pharmaceutical Technology

JULY 15, 2022

The UK National Institute for Health and Care Excellence (NICE) has recommended Novartis Pharmaceuticals UK’s Piqray (alpelisib) along with hormonal therapy fulvestrant to treat hormone receptor+, HER2-, PIK3CA-mutated locally advanced or metastatic breast cancer.

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Camargo

NOVEMBER 29, 2021

The development of biological products (or biologics) represents a major advancement in modern medicine, enabling the treatment of patients with many illnesses where no other therapeutics were previously available. Recombinant therapeutic proteins. Fusion proteins. Gene and cellular therapies. Growth factors. Interferons.

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Pharmaceutical Technology

MAY 31, 2023

The therapeutic candidate targets immune checkpoint, programmed cell death protein 1 (PD1). The company’s portfolio of marketed products treats central nervous system (CNS) disorders, cardiovascular diseases, cancer, ENT disorders, respiratory diseases, hematological disorders, hormonal disorders, and others.

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Pharmaceutical Technology

FEBRUARY 14, 2023

Alkaloids, natural dyes, drugs, proteins, and enzymes are some of the important classes of natural heterocyclic compounds essential for human life. The company filed heterocyclic composition patents in areas such as PAD4 inhibitors, factor Xa inhibitors, and nuclear hormone receptor modulators.

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The Pharma Data

JUNE 26, 2021

Basel, June 23, 2021 — VISION data published today in The New England Journal of Medicine (NEJM) shows that 177 Lu-PSMA-617 plus standard of care (SOC) significantly improved both overall survival (HR = 0.62 [95% CI: 0.52?0.74]; 0.74]; P<0.001; median 15.3 months) and imaging-based progression-free survival (HR = 0.40 [99.2%

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Pharmaceutical Technology

APRIL 24, 2023

“Biologics products may contain proteins that control the action of other proteins and cellular processes, genes that control production of vital proteins, modified human hormones, or cells that produce substances that suppress or activate components of the immune system.

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The Pharma Data

MAY 14, 2021

Metabolic Breakthrough Rebalances Your “Hot Zone Hormones” So Any Woman Over 35 Can Blast Off Belly Fat, Shape Flabby Muscle And See Your Most Attractive,Youthful, And Energized Body Ever In Only 30 Days WITHOUT Suffering Through Restrictive Diets Or Trying To Starve Yourself Skinny. Helping you Permanently Blast off Belly Fat.

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The Pharma Data

SEPTEMBER 16, 2020

Blueprint Medicines will present new data from the registrational phase I/II ARROW trial, investigating Gavreto TM (pralsetinib) for the treatment of people with RET-mutant medullary thyroid cancer. Gavreto is being jointly commercialised by Genentech, a wholly owned member of the Roche Group, and Blueprint Medicines in the U.S.

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XTalks

FEBRUARY 7, 2023

Current treatments for HR+ breast cancer patients include hormonal therapies, chemotherapies for those that do not respond to hormonal therapy alone and targeted therapies, either stand-alone or in combination with hormonal therapies. What does this Approval Mean for Breast Cancer Patients?

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The Pharma Data

MARCH 22, 2021

These groundbreaking data confirm our belief in the potential of 177 Lu-PSMA-617 to reimagine outcomes for these patients through phenotypic precision medicine. We would not be able to realize our commitment to reimagining medicine without the partnership of patients and their families.”.

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XTalks

FEBRUARY 5, 2024

Why it did so well: In 2022, Avastin was Roche’s eighth best-selling drug, but as expected, the impact of biosimilars caused the sales of this cancer medicine to decrease by 28 percent compared to 2021. Ramucirumab may be given alone or in combination with other cancer medicines. USD) per month for a 70 kg patient. to $17,138.76

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The Pharma Data

OCTOBER 14, 2020

The highly potent and selective payload series represents a powerful new class within ADC development with novel protein alkylating cytotoxicity. Talking Medicines – Scotland’s Talking Medicines will join Tech Nation’s Applied AI 2.0 CARB-X will provide Polyphor with initial funding of up to $2.62 Growth Programme.

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XTalks

JUNE 10, 2024

Efruxifermin is a novel Fc-FGF21 fusion protein designed to emulate the activity of native FGF21, an endogenous hormone that regulates metabolism and alleviates cellular stress. It can lead to inflammation, fibrosis, cirrhosis, liver failure and potentially death.

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The Pharma Data

AUGUST 30, 2021

TNBC remains the most challenging type of breast cancer to treat, which makes the decision to withdraw so difficult for us, as patients have had this medicine as an important option for more than two years,” said Levi Garraway, M.D., This is not related to any changes in either the efficacy or safety associated with Tecentriq. receptors.

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The Pharma Data

APRIL 27, 2021

The FDA’s Accelerated Approval Program allows for conditional approval of a medicine that fills an unmet medical need for a serious condition, with specific postmarketing requirements (PMRs) to confirm the clinical benefit and convert to regular approval. receptors.

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The Pharma Data

APRIL 27, 2022

The Food and Drug Administration’s (FDA) BTD is designed to accelerate the development and regulatory review of potential new medicines that are intended to treat a serious condition and address a significant unmet medical need. 1-4 Low HER2 expression occurs in both HR-positive and HR-negative disease.

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The Pharma Data

MAY 15, 2021

SLIM OVER 55 is THE ONLY program for women over 55 that is especially designed for your body who has gone through menopause and needs to get all the hormones back in balance! Each of the Slim Over 55 meals are perfectly balanced with precise nutrients, carbohydrates, proteins, vitamins and the healthiest of fats.

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The Pharma Data

MARCH 25, 2021

SG is a first-in-class therapy targeting Trop-2, a protein frequently expressed in multiple types of epithelial tumors, such as TNBC, where high expression is associated with poor survival and relapse. Canada, Switzerland and Australia, as well as in Singapore through our partner Everest Medicines. Gilead Sciences, Inc.

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The Pharma Data

MAY 16, 2021

She goes further to teach you things like how to get out of or avoid plateaus, and even how to manipulate your own hormone production for better, and desirable biological responses. In her book Karen teaches you nutrition, resistance training, resting, supplementation. And it doesn’t stop there. ” Ivan Nikolov.

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The Pharma Data

APRIL 7, 2021

Trodelvy is directed to the Trop-2 receptor, a protein frequently expressed in multiple types of epithelial tumors, including TNBC, where high expression is associated with poor survival and relapse. The European Medicines Agency has also validated a Marketing Authorization Application for Trodelvy in the European Union. months vs. 6.9

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The Pharma Data

MAY 16, 2021

And, most importantly, your body doesn’t get enough protein. Protein contains essential amino acids which are vital for supporting your body and muscle growth. Sure, you drop weight within days and weeks of starving yourself but who wouldn’t, right? To continue dropping fat, you have to starve yourself even more.

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The Pharma Data

DECEMBER 27, 2020

We are appreciative of our team’s efforts and our collaboration with Amgen in developing and commercializing these medicines, and understand that this accomplishment would not have been possible without China’s commitment to innovative, high-quality treatments through ongoing drug reform and the Healthy China initiative.”.

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XTalks

FEBRUARY 5, 2024

Why it did so well: In 2022, Avastin was Roche’s eighth best-selling drug, but as expected, the impact of biosimilars caused the sales of this cancer medicine to decrease by 28 percent compared to 2021. Ramucirumab may be given alone or in combination with other cancer medicines. USD) per month for a 70 kg patient. to $17,138.76

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The Pharma Data

APRIL 7, 2023

The safety and tolerability of these combinations are broadly consistent with that observed in prior clinical trials and the known profiles of the individual medicines. The companies develop Lynparza in combination with their respective PD-L1 and PD-1 medicines independently. Source link: [link]

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The Pharma Data

APRIL 14, 2021

Tagawa, MD, MS, FACP, Professor of Medicine and Urology at Weill Cornell Medicine, an oncologist at New York-Presbyterian/Weill Cornell Medical Center and principal investigator of the TROPHY study. Canada, Switzerland and Australia, as well as in Singapore through our partner Everest Medicines. About Trodelvy.

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The Pharma Data

JUNE 18, 2021

lead study investigator of the Phase 3 RESONATE-2 trial, and Professor of Medicine at the Wilmot Cancer Institute, University of Rochester. The BTK protein sends important signals that tell B cells to mature and produce antibodies. IMBRUVICA ® is the only FDA-approved medicine in WM and cGVHD. Barr , M.D., Taking IMBRUVICA ® ?with

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