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Researchers at the University of Lige (Belgium) have uncovered a previously unknown mechanism that regulates the immuneresponse against parasites. This discovery could help in better-controlling inflammation and improving immuneresponses to infections.
An initial look at the vaccine's effects on the elderly shows those in their 70s had similar responses to those under 55, Moderna told a government panel.
Results suggested Pfizer's and Moderna's vaccines may serve as a more potent booster for those who initially received Johnson & Johnson's shot, although data are limited and preliminary.
The trial results should allow the company to ask the FDA for approval of its vaccine in younger children, just as Pfizer nears a crucial decision for its shot in 5- to 11-year olds.
The results position Pfizer and BioNTech to seek clearance in children as young as five years old. But the companies haven't yet shared data on a rare heart inflammation associated with their shot that's a concern for regulators.
Research, led by the Peter Doherty Institute for Infection and Immunity (Doherty Institute) and the Peter MacCallum Cancer Center (Peter Mac), have identified a rare type of immune cells, called stem-like T cells, that holds the key to maintaining powerful, long-term immuneresponses.
The biotech claims study results could position its reformulated vaccine as a booster in the fall, though it’s unclear how well the shot can prevent sickness caused by omicron or newer strains of the variant.
Scientists at the National Institutes of Health (NIH) unit National Institute of Neurological Disorders and Stroke (NINDS) have found that Covid-19-induced immuneresponse could damage the blood vessels of the brain and may lead to short and long-term neurological symptoms. .
The vaccine didn’t spur a strong enough immuneresponse against a particular flu strain in a Phase 3 trial, leading the companies to ponder adjustments.
A third shot sparked a strong immuneresponse in clinical testing, positioning the companies to make boosters available to the roughly 28 million kids in the U.S. who became eligible for their first two doses late last year.
As worries about coronavirus mutations grow, Gritstone Oncology will work with the NIH to develop a shot capable of stimulating a broad immuneresponse.
New results show the two-pronged booster the FDA cleared in August sparks a stronger immuneresponse against omicron and its subvariants than Moderna’s original shot.
The experimental shot produced a weak immuneresponse in adults over 49, leading the partner drugmakers to change plans and push back their development timelines.
A study conducted by researchers at the Kennedy Institute of Rheumatology has uncovered a pivotal role of asparagine metabolism in regulating B cell homeostasis and immuneresponse.
and South Africa, although the latter appeared to result in a weaker immuneresponse. Laboratory tests indicated the biotech's shot would still protect against virus variants detected in the U.K.
Gut bacteria that break down a sugar called fucose could be dampening our immuneresponse to the COVID-19 mRNA vaccine, according to a study led by researchers from the Okinawa Institute of Science and Technology (OIST).
Intranasal delivery of ChAdOx1 nCoV-19 failed to induce either a consistent mucosal antibody response or a strong systemic immuneresponse, according to results from a Phase 1 clinical trial released today.
The shot appears to generate an immuneresponse that matches or exceeds existing vaccines, but investigators aren’t yet sure how well it can prevent illness.
The identification of these novel clinical biomarkers allows researchers to better understand complex mechanisms of immuneresponse to diseases, facilitating the development of more effective therapeutics.
A second shot given six months after the first appears to provide a bigger immuneresponse, the company said, a finding J&J aims to take to regulators in the U.S. and elsewhere.
When non-invasive sound waves break apart tumors, they trigger an immuneresponse in mice. By breaking down the cell wall "cloak," the treatment exposes cancer cell markers that had previously been hidden from the body's defenses, researchers at the University of Michigan have shown.
Data from a small Phase 1 trial showed the biotech's vaccine spurred immuneresponses to four common strains, although they didn't appear significantly greater than an already available shot from Sanofi.
A new study by investigators from the Smidt Heart Institute at Cedars-Sinai suggests long COVID-19 might be caused by a dysfunction of the immune system.
This innovative composition induces a protective immuneresponse against Group A Streptococcus (GAS) bacteria, offering potential targets for vaccine development. Discover a groundbreaking immunogenic composition patent that combines GAS polypeptide antigens and polypeptide-polysaccharide conjugates.
The pharma said its latest shot, which covers 21 strains of bacteria, cleared two Phase 3 trials and in some cases spurred a stronger immuneresponse than Pfizer’s Prevnar 20.
A recent study from a team of researchers from the University of Nebraska–Lincoln and other institutions, however, has found that a subset of taste cells called type II taste cells may play a key role in the body's immuneresponse to harmful oral microbes.
Within a study by investigators at Weill Cornell Medicine and NewYork-Presbyterian, the long-term immuneresponse to SARS-CoV-2 mRNA vaccination was similar in pregnant individuals and non-pregnant individuals of reproductive age.
The human body is capable of creating a vast, diverse repertoire of antibodies—the Y-shaped sniffer dogs of the immune system that can find and flag foreign invaders.
In a new study by researchers from Mass General Brigham's founding members, Brigham and Women's Hospital and Massachusetts General Hospital, a team extensively investigated the immuneresponse of 16 adolescents and young adults who developed myocarditis after receipt of the COVID mRNA vaccine.
As a major component of the immune system, T cells play a critical role in fighting off viral infections. A team led by Prof. Thomas Brocker and Jan Kranich from LMU's Biomedical Center has demonstrated in a mouse model that so-called extracellular vesicles play an important part in the stimulation of these cells.
A new HIV vaccine from Scripps Research has shown a significantly improved ability to neutralize the virus in preclinical tests, and it will soon be studied in healthy people who volunteer to participate in clinical trials.
Lipids influence how our cells behave and function, which affects many processes in the body including the immune system. When we consume fats (also called lipids) in our diet, they can be metabolized or stored to provide energy for the body. But they are also involved in regulating the genes expressed within—and the signaling between—cells.
Formed after exposure to a pathogen or vaccine, germinal centers act as a kind of immune system training academy, helping B cells refine their response to the threat. Cells jostling for a spot in a germinal center face a cutthroat admissions process.
The company’s shot sparked a strong enough immuneresponse against only one of two groups of influenza strains it was tested against in a closely watched Phase 3 trial.
The agency also cleared booster shots of all three currently available vaccines to be used interchangeably, a so-called mix-and-match approach that recent study results showed could boost immuneresponses.
Study results showed two shots of Moderna's vaccine led to similar immuneresponses as has been observed in young adults, although protection versus omicron was modest.
Cancer drugs that stimulate the body's immune system to attack tumors are a promising way to treat many types of cancer. However, some of these drugs produce too much systemic inflammation when delivered intravenously, making them harmful to use in patients.
The findings, which were disclosed in a press release without specific data, are the first immuneresponse results in humans for the reformulated shot targeting the BA.4 5 substrains.
The phrase “Black Death mass burial site” tends to evoke images of haphazard piles of diseased deceased like the “bring out your dead” Monty Python scene.
Past neuroscience studies have consistently demonstrated that the aging of the mammalian nervous system is liked with a decline in the volume and functioning of white matter, nerve fibers found in deep brain tissues.
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