XTalks

FEBRUARY 5, 2025

Avtozma is a recombinant humanized monoclonal antibody that acts as an interleukin 6 (IL-6) receptor antagonist that works by targeting specific inflammatory proteins to dampen immune responses. Avtozma was submitted for regulatory approval to the FDA in January 2024 and the European Medicines Agency (EMA) in February 2024.

FDA Approval 102

FDA Approval Marketing Antibody Immune Response 102

XTalks

NOVEMBER 15, 2024

These RXR receptors play a key role in regulating transcription pathways involved in inflammation and immune responses, among other cancer hallmarks, to modulate the tumor microenvironment. Tamibarotene is a selective agonist of retinoic acid receptor alpha/beta, with potential binding to retinoid X receptors (RXR).

Trials 105

Trials HR Immune Response FDA Approval 105

XTalks

OCTOBER 24, 2024

In August 2024, Artax Biopharma completed patient recruitment for its Phase IIa trial of AX-158, exploring a new immune-modulating therapy for psoriasis. Meanwhile, Innovent Biologics recently saw its New Drug Application (NDA) for picankibart, an IL-23p19 inhibitor, accepted by the Chinese National Medical Products Administration (NMPA).

Research 105

Research Dermatology Clinical Trials Clinical Trials 105

XTalks

SEPTEMBER 29, 2021

The data shows that the vaccine is safe, well-tolerated and elicits robust immune responses in this age group. Subscribe to the Xtalks Life Science Podcast to never miss a new episode. Hear about some of the factors that are influencing vaccine hesitancy among parents.

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Life Science Vaccination Vaccine Immune Response 52

XTalks

NOVEMBER 3, 2021

The authorization was based on trial data that showed the vaccine was safe, well-tolerated and induced robust immune responses among children in this age group; side effects were generally mild to moderate. Subscribe to the Xtalks Life Science Podcast to never miss a new episode.

Life Science 52

Life Science Drug Delivery Systems Vaccination Vaccine 52

XTalks

DECEMBER 30, 2024

has announced promising Phase IIb results for cenerimod, an investigational drug targeting immune system dysfunction in moderate-to-severe systemic lupus erythematosus (SLE). SLE is an autoimmune disease where the immune system attacks healthy tissues, causing inflammation, pain and potential organ damage. Viatris Inc.

Immune Response 52

Immune Response Gene Expression Drugs Trials 52

XTalks

DECEMBER 20, 2024

Importantly, patients switching from Stelara to Steqeyma maintained stable anti-drug antibody (ADA) levels, demonstrating consistent immune responses to the drug over time. By blocking these inflammatory pathways, it helps manage overactive immune responses in conditions like psoriasis and Crohns disease.

FDA Approval 52

FDA Approval Immune Response Antibody Marketing 52

pharmaphorum

MARCH 4, 2021

UK chancellor Rishi Sunak has announced a budget loaded with initiatives designed to kick-start the UK’s economy as it recovers from the coronavirus pandemic, with vaccine development, pharma and life sciences playing a key role. A scheme providing £500 payments to people self-isolating has been extended in England until the summer.

Vaccination 105

Vaccination Vaccine Development Life Science 105

pharmaphorum

JULY 18, 2022

It then elicits an immune response against that spike protein. You have a response with immunoglobulins type G (antibodies) and robust cellular response with both CD4 and CD8 T-cells being activated,” Morgon states. We get a higher immune response with the inhaled compared to the injectable,” Morgon relays.

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Vaccination Vaccine Development Immune Response 138

XTalks

DECEMBER 15, 2021

The results showed that the vaccine had no serious safety concerns and elicits immune responses against four different strains of the influenza virus. Subscribe to the Xtalks Life Science Podcast to never miss a new episode. An mRNA-based flu shot can be developed more rapidly than a traditional flu shot.

Life Science 40

Life Science FDA Approval Vaccination Vaccine 40

XTalks

OCTOBER 12, 2021

The vaccine was tested in rats and showed strong, immediate and long-lasting immune responses to confer protection against the disease. is an autoantigen, which means it is an endogenous antigen that triggers an immune response in the body. as a potential trigger for rheumatoid arthritis.

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Vaccination Vaccine Research Immune Response 105

The Pharma Data

NOVEMBER 10, 2020

Weiner, chairman of the scientific advisory board of Tiziana Life Sciences, commented: “We understand that this will be the first-ever study with ‘take-home’ capsules of any mAb for immunotherapies for human diseases. Tiziana Life Sciences January 9, 2020 Press Release ( [link] ). Billion by 2025. and Europe.

Life Science 40

Life Science Clinical Trials Clinical Trials Trials 40

XTalks

NOVEMBER 6, 2020

Symvivo’s bacTRL Gene Therapy Platform is designed and optimized to address limitations associated with typical vaccines, including the inability to accommodate large or multiple genes, lack of specificity to targeted tissue and poor control over immune response, says the company.

Clinical Trials 75

Clinical Trials Clinical Trials Vaccination Vaccine 75

BioTech 365

OCTOBER 22, 2020

-Proof-of-concept achieved for VY-UC to engineer donor cells without the complexities of gene-editing -Novel platform abrogates cellular immune response and obviates the need for immunosuppressive drugs TAMPA, Fla. & an immuno-centric discovery life science company with a … Continue reading →

Gene Editing 40

Gene Editing Immune Response Life Science Engineer 40

XTalks

AUGUST 26, 2020

The anti-inflammatory macrophages help in preventing an immune response from becoming dangerous, as seen with patients with autoimmune disease. This helps to ensure that inflammation naturally subsides after the initial immune response and promotes tissue repair.

Bacteria 105

Bacteria Immune Response Protein Medicine 105

pharmaphorum

JULY 20, 2021

According to some studies, beta may be the most likely to evade immune responses stimulated by the currently available shots as well as some antibody drugs for SARS-CoV-2, and is also thought to be more transmissible. 1.351) variant first identified in South Africa.

Vaccination 98

Vaccination Vaccine Protein Immune Response 98

XTalks

DECEMBER 14, 2021

Moderna revealed the first interim results from a small, Phase I study of its mRNA-based influenza vaccine, which showed that the vaccine had no significant safety concerns and elicited immune responses against four strains of the influenza virus. There were no significant safety findings reported through day 29. Mixed Results.

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Vaccination Vaccine Immune Response Antibody 98

XTalks

JULY 28, 2021

While Merck’s previous shot, Pneumovax 23, defends against 23 serotypes and has been on the market for almost four decades, the immune responses it generates are not as durable as Prevnar 13. This is why Pfizer’s Prevnar 13 has dominated the pneumonia vaccine space for more than a decade.

FDA Approval 89

FDA Approval Vaccination Vaccine Immune Response 89

XTalks

JANUARY 20, 2025

Sasanlimab, a subcutaneous anti-PD-1 therapy, offers a novel immunotherapy approach that enhances the anti-tumor immune response. Moreover, 40-50% of patients experience recurrent disease requiring the need for cystectomy, which is associated with significant risks and bladder-sparing treatment options remain limited.

Antibody 52

Antibody Trials Clinical Trials Clinical Trials 52

XTalks

JANUARY 8, 2021

The depth of the immune response is associated with the duration of protection. The few that did receive only one dose were not followed for a long period of time. The FDA therefore maintains that no definitive conclusions can be drawn about the depth of protection that a single dose would confer.

Vaccination 144

Vaccination Vaccine Clinical Trials Clinical Trials 144

XTalks

JANUARY 20, 2025

Sasanlimab, a subcutaneous anti-PD-1 therapy, offers a novel immunotherapy approach that enhances the anti-tumor immune response. Moreover, 40-50% of patients experience recurrent disease requiring the need for cystectomy, which is associated with significant risks and bladder-sparing treatment options remain limited.

Antibody 52

Antibody Trials Clinical Trials Clinical Trials 52

XTalks

APRIL 18, 2022

Accomplishing strong immune responses with low doses is crucial in the development of well-tolerated and highly effective vaccines. “We pioneered the treatment of the first patient in history with nano-sized lipid-encapsulated mRNA back in 2015, after years of extensive research.

Vaccination 105

Vaccination Vaccine Development Immune Response 105

XTalks

JULY 31, 2024

Alopecia areata can be triggered by genetics, immune system dysfunction and environmental factors. Leqselvi works by selectively inhibiting the Janus kinases (JAK) JAK1 and JAK2, pathways that play a key role in this misguided immune response.

Immune Response 105

Immune Response Dermatology Clinical Trials Clinical Trials 105

XTalks

FEBRUARY 19, 2024

The study compared the immune responses evoked by Moderna’s mRNA vaccine to those generated by a previous vaccine candidate, namely, the MF59-adjuvanted glycoprotein B (gB) proten subunit vaccine (gB/MF59) developed by Sanofi. Paduano Professor in Pediatrics at Weill Cornell Medicine, in a news release.

Vaccination 59

Vaccination Vaccine Trials Clinical Trials 59

XTalks

DECEMBER 29, 2023

Classified as a bispecific T-cell engager (BiTE molecule), tarlatamab consists of two essential parts: one binds to T-cells, vital in immune response, and the other targets cancer cells. Tarlatamab differs from conventional chemotherapy as it’s an immunotherapy designed to help immune cells detect, attach to and fight cancer cells.

Clinical Trials 119

Clinical Trials Clinical Trials FDA Approval Trials 119

XTalks

JANUARY 20, 2021

While diseases like celiac are associated with inappropriate activation of the immune system triggered by food antigens, this is not the case in IBS. In a normal, healthy intestine, foods do not trigger immune responses and so in a patient with IBS, something else must activate the response. Mouse and Human Studies.

Immune Response 52

Immune Response Research Allergies Protein 52

XTalks

APRIL 7, 2021

The test is intended for the detection of COVID-19 infection, either a recent or previous infection, as detected through an adaptive antibody immune response to SARS-CoV-2. The test involves self-collection of a fingerstick dried blood sample.

Antibody 102

Antibody Immune Response Radiology Marketing 102

pharmaphorum

MARCH 23, 2021

In the case of AU-011, the VLPs are conjugated to an infrared dye called IRDye 700DX that when exposed to a laser causes direct damage to malignant cells and activates an immune response to the tumour, without damaging the healthy structures in the eye.

Development 71

Development Drugs Immune Response Life Science 71

XTalks

SEPTEMBER 15, 2020

The vaccine triggers an immune response against pro-inflammatory processes resulting from autoimmune attack of the pancreas – the inflammation helps to destroy the insulin-producing ?-islet How the Type 1 Diabetes Vaccine Works. islet cells of the organ, giving rise to the disease. cells of the pancreas.

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Vaccination Vaccine Insulin Trials 103

XTalks

NOVEMBER 22, 2022

The drug is a CD3-directed antibody that destroys autoreactive T lymphocytes that attack insulin-producing beta cells, while increasing the proportion of regulatory T cells and exhausted CD8+ T cells in the peripheral blood that help manage the immune response to delay progression to stage 3 type 1 diabetes.

Insulin 97

Insulin Drugs FDA Approval Immune Response 97

XTalks

AUGUST 13, 2020

In a press statement , Kaiser Permanente outlined that in this phase of the trial, data will be collected about the safety, immune response and efficacy of the vaccine candidate as required for regulatory review.

Vaccination 89

Vaccination Vaccine Trials Clinical Trials 89

XTalks

JUNE 15, 2022

protein that triggers the immune system to generate antibodies against the virus. Adjuvants can help boost the effectiveness of a vaccine and elicit a stronger immune response. Compared to adults, immune responses were approximately two- to three-fold higher in adolescents. The vaccine is given in two doses.

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Vaccination Vaccine Immune Response Protein 59

XTalks

NOVEMBER 23, 2020

Oxford-AstraZeneca COVID-19 Vaccine Induces Immune Responses in Early Clinical Trials. The global trials are assessing the safety and efficacy of the vaccine in individuals aged 18 years or over from diverse racial and geographic groups who are healthy or have stable underlying medical conditions.

Vaccination 97

Vaccination Vaccine Clinical Trials Clinical Trials 97

XTalks

NOVEMBER 10, 2020

Interim results of the trial show that all participants developed an antibody response after two doses of the COVID-19 adjuvanted vaccine candidate. Adjuvants are used to help stimulate stronger vaccine immune responses. These are very promising results. Plant-Based Vaccine Technology.

Vaccination 52

Vaccination Vaccine Trials Immune Response 52

XTalks

JULY 2, 2021

Vaccines could cause an inflammatory response as part of the overall immune response. Inflammation could be another possible link between vaccination and the observed menstrual changes. There is evidence that people with signs of inflammation from infection had more painful periods.

Vaccination 105

Vaccination Vaccine Protein Immune Response 105

XTalks

MAY 30, 2023

Novel treatments: Ongoing research into new treatments for MS include novel immunomodulatory drugs that aim to modulate or suppress the immune response that attacks the myelin sheath in MS. Research has shown that non-genetic factors such as low vitamin D levels, smoking, stress and certain viral infections may increase the risk of MS.

Genetics 98

Genetics Research Immune Response Drugs 98

XTalks

AUGUST 16, 2021

Immune systems can be weakened in individuals with HIV/AIDS; cancer and transplant patients taking certain immunosuppressive drugs; and those with genetic diseases affecting the immune system like congenital agammaglobulinemia and congenital IgA deficiency. Related: CDC Backs J&J COVID-19 Shot Amid GBS and Delta Variant Concerns.

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Vaccination Vaccine Antibody Immune Response 104