Medical Xpress

JANUARY 20, 2023

Scientists have long sought to better understand the human body's immune responses that occur during various diseases, including cancer and inflammatory diseases.

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Medical Xpress

FEBRUARY 21, 2023

PCB2DG, a polyphenol with anti-inflammatory properties, works by targeting and directly interacting with the major glutamine transporter protein, alanine serine cysteine transporter 2 (ASCT2), to inhibit the uptake of glutamine, an important amino acid found in the blood.

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Immune Response Regulation Protein 75

Drug Patent Watch

DECEMBER 9, 2024

Additionally, the immunogenicity of biosimilars, which is the ability of the drug to trigger an immune response, can be highly variable and impact the safety and efficacy of the drug.

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Clinical Trials Clinical Trials Immune Response Production 97

XTalks

NOVEMBER 15, 2024

These RXR receptors play a key role in regulating transcription pathways involved in inflammation and immune responses, among other cancer hallmarks, to modulate the tumor microenvironment. Tamibarotene is a selective agonist of retinoic acid receptor alpha/beta, with potential binding to retinoid X receptors (RXR).

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Trials HR Immune Response FDA Approval 105

Pharmaceutical Technology

JUNE 30, 2022

HDT Bio has received Emergency Use Approval from Indian regulators for its Covid-19 vaccine, Gemcovac. This technology can stimulate an immune response with a dose up to 20 times lower than current vaccines, which enhances safety, lowers costs, and increases production speed. .

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BioPharma Reporter

DECEMBER 11, 2020

Sanofi and GSK announced a delay on Friday in their adjuvanted recombinant protein-based COVID-19 vaccine program to improve immune response in the elderly, saying clinical trials showed an insufficient immune response in older people.

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Immune Response Vaccine Vaccination Trials 105

BioPharma Reporter

NOVEMBER 9, 2020

Agenus Inc, an immuno-oncology company with a pipeline of agents designed to activate immune response to cancers and infectious diseases, has reported the dosing of the first COVID-19 patient with agenT-797, an allogeneic cell therapy, through its subsidiary, AgenTus Therapeutics.

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Immune Response Regulation Marketing 121

Scienmag

DECEMBER 9, 2021

When the body attempts to fight off an infection, immune cells called neutrophils may shoot out spider web-like networks of toxic proteins to help contain the invaders. Utilizing […].

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Medical Xpress

DECEMBER 16, 2022

Scientists from Trinity College Dublin have made an important breakthrough in understanding how inflammation is regulated. They have just discovered that a key immune alarm protein previously believed to calm down the immune response actually does the opposite.

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Immune Response Protein Scientist Regulation 80

pharmaphorum

JANUARY 15, 2021

Latest data give hope that the vaccine could be added to the campaign after phase 1/2a data showed that the shot provided an immune response that lasted for at least 71 days, the duration of time measured in the study involving patients aged 18-55 years. J&J expects to file with the FDA first, followed by other regulators.

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Vaccine Vaccination Immune Response Antibody 119

pharmaphorum

NOVEMBER 19, 2020

The coronavirus vaccine being developed by Oxford University and AstraZeneca produces a strong immune response in higher risk older patients, a study has found. Although both vaccines are not yet approved by regulators, the results are encouraging as older people seem to be most at risk from the virus.

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Immune Response Vaccine Vaccination Regulation 105

Pharmaceutical Technology

APRIL 11, 2023

The vaccine, which generates the SARS-CoV-2 viral spike protein on administration, induces the immune system’s cellular and humoral arm-mediated immune response. It carries out operations in the regulated markets of the US and Europe, as well as in Latin America and South Africa.

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XTalks

DECEMBER 30, 2024

has announced promising Phase IIb results for cenerimod, an investigational drug targeting immune system dysfunction in moderate-to-severe systemic lupus erythematosus (SLE). SLE is an autoimmune disease where the immune system attacks healthy tissues, causing inflammation, pain and potential organ damage. Viatris Inc.

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Immune Response Gene Expression Drugs Trials 52

XTalks

NOVEMBER 12, 2024

Adjunctive Therapies Using Immune Modulators Immune modulators, which help to regulate the body’s immune response, are increasingly recognized as supportive treatments for pneumonia. These therapies work by controlling excessive inflammatory responses in the lungs.

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Bacteria Life Science Vaccine Vaccination 110

BioPharma Reporter

SEPTEMBER 14, 2021

Johnson & Johnson says data published in The Lancet on its Ebola vaccine regimen shows it has a robust and durable immune response in adults and children.

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Vaccine Vaccination Immune Response Regulation 93

pharmaphorum

JUNE 30, 2021

Just a few months after starting clinical trials of its nasal spray vaccine for COVID-19, US biotech Altimmune is abandoning the project, saying that it generated weaker than expected immune responses in a phase 1 trial. . We believe that prior immunity in humans may be important for a robust immune response to intranasal dosing.”

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Vaccine Vaccination Trials Immune Response 98

Pharmaceutical Technology

JANUARY 19, 2023

The findings showed that the Nuvaxovid booster dose increased immune responses compared to higher levels associated with the protection in Phase III clinical trials. Nuvaxovid demonstrated a significant antibody response when given as a booster dose after primary vaccination with other authorised Covid-19 doses in the COV-BOOST trial.

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Camargo

DECEMBER 13, 2021

The regulations regarding BLAs for therapeutic biological products are included in 21 CFR parts 600 , 601 , and 610. CBER regulates products under a variety of regulatory authorities: INDs for CBER-regulated products. Section 351(a) is the traditional pathway for approving biologics under the PHS Act. BLA process (CBER).

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Development Production Immune Response Licensing 161

pharmaphorum

JANUARY 5, 2022

A COVID-19 vaccine that could work against multiple variants of the coronavirus – developed by US biotech Gritstone bio – has generated encouraging immune response data in its first clinical trial. “With new variants – like Omicron and B.1.640.2

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Protein Vaccine Vaccination Immune Response 126

STAT News

OCTOBER 19, 2022

1 subvariant of Omicron generated a strong immune response against that variant, with antibody levels staying high for at least three months , Reuters notes. Omicron-tailored  Omicron-tailored shots by Pfizer and Moderna are already authorized by regulators in several countries. 5 subvariants of Omicron.

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Immune Response Scientist Vaccine Vaccination 98

pharmaphorum

NOVEMBER 26, 2020

As pointed out by Canada’s CBC , the change was okayed by regulators but nevertheless the stronger effect could still be a statistical quirk. Younger people would tend to produce a stronger immune response than older people, which could account for the differing results.

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Vaccine Vaccination Trials Immune Response 98

Drug Discovery Today

APRIL 5, 2022

Researchers delve into the inner workings of the antibody immune response, finding key differences in the metabolism of two closely related immune cell subsets.

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Immune Response Regulation Antibody Research 45

pharmaphorum

DECEMBER 4, 2020

Subject to approval from regulators the vaccine specialist said it plans the trial known as VLA15-221 as a randomised, observer-blind phase 2 study including around 600 healthy people aged 5-65 years of age. VLA15 has demonstrated a promising immune response and safety data in pre-clinical and clinical studies so far.

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pharmaphorum

FEBRUARY 22, 2021

In December interim phase 1/2 trial results showed the vaccine produced a lower immune response in older adults. At the time analysts said that this was likely due to an insufficient concentration of the antigen and the companies have refined their antigen formulation hoping for a better immune response including in older adults.

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Scienmag

NOVEMBER 13, 2020

Whether the signaling molecule IL-33 wakes up or turns down the immune response depends on what cell type releases it, School of Veterinary Medicine researchers found. ” “The mantra of my […].

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Immune Response Regulation Medicine Research 46

Worldwide Clinical Trials

JUNE 21, 2024

Clinical researchers are currently working to streamline TIL production and enhance treatment outcomes by more efficiently regulating immune responses — such as combination therapy with checkpoint inhibitors.

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Antibody Clinical Trials Clinical Trials In-Vitro 162

Scienmag

MAY 4, 2021

Credit: Lin-Feng Chen A new study, published in JCI Insight, looks at how Brd4, a regulator of the innate immune response, influences diet-induced obesity. The researchers believe that Brd4 could be used as a target for obesity and insulin resistance. Approximately one-third of the adults and one in five children in the U.S.

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Immune Response Insulin Regulation Research 55

Scienmag

APRIL 29, 2021

An ancient immune response regulates the development of beneficial symbioses Credit: Natascha Bechtoldt Microalgae of the dinoflagellate group are known for their ability to survive in other animal cells. These tiny single-cell organisms have engaged in mutually beneficial relationships with corals since primeval times.

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Immune Response Regulation Development 53

pharmaphorum

SEPTEMBER 24, 2020

” A vaccine is seen as a way out of the social distancing and lockdown regulations that are crippling large parts of the economy and causing immense disruption to peoples’ lives. Although controversial, as the subjects would be exposed to a potentially lethal virus, the trial could provide data about the immune response for any vaccine.

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Vaccine Vaccination Trials Immune Response 97

pharmaphorum

DECEMBER 11, 2020

Interim results from a phase 1/2 clinical trial show the immune response from Sanofi/GSK’s vaccine produced a lower immune response in older adults. While antibody levels were comparable to those seen in recovering COVID-19 patients in adults aged 18-49, the response was lower in older adults.

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Immune Response Trials Vaccine Vaccination 69

pharmaphorum

APRIL 16, 2021

The authors were quick to point out that the findings do not apply to the AstraZeneca vaccine that has been at the centre of a safety crisis in recent weeks, with regulators limiting their use in younger people and Denmark pulling the vaccine completely this week. It is associated with an immune response.”

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Vaccine Vaccination Immune Response Research 105

pharmaphorum

DECEMBER 22, 2020

Sahin was addressing a news conference after the vaccine was approved by the European Union, three weeks after the shot was independently backed by the UK’s regulator. But scientifically, it is highly likely that the immune response by this vaccine also can deal with the new virus variants.”.

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Vaccine Vaccination Protein Immune Response 81

Find Me Cure

APRIL 23, 2020

For example, if you become immune but this immunity only lasts for a few weeks, this is not long enough to allow for a good proportion of the population to become infected and then immune as well. Thus, herd immunity wouldn’t work in this scenario.

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Immune Response Antibody Scientist Development 117

pharmaphorum

FEBRUARY 8, 2021

China’s national regulator has approved Sinovac Biotech’s COVID-19 vaccine for use by the general public. It works by using inactivated viral particles to expose the immune system, which mounts an immune response that fights off the active virus in the event of an infection.

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Vaccine Vaccination Immune Response Regulation 89

XTalks

APRIL 26, 2021

Moreover, a very strong immune response is needed to fend off the disease. The vaccine is protein-based and contains an adjuvant (MM), a component that helps generate a stronger immune response, that was developed by Novavax. Malaria Vaccine Phase II Trial. At six months, 29.5 Changing the Face of Malaria.

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Vaccine Vaccination Immune Response Trials 105

pharmaphorum

JANUARY 6, 2023

The idea is to use mRNA sequences in the shot that target multiple cancer antigens and are designed to stimulate a multi-pronged immune response against tumours, with the potential for the therapy to eventually be individualised for patients based on their cancer’s molecular profile.

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Clinical Trials Clinical Trials Trials Vaccine 111

pharmaphorum

APRIL 22, 2022

Shares in the US biotech have fallen sharply after it revealed that the regulator did not accept changes to a phase 3 trial of the drug – called Ampion – that the company put forward in order to make it serve as a confirmatory pivotal study.

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Immune Response Trials Clinical Trials Clinical Trials 111