Pharmaceutical Technology

JANUARY 9, 2023

Additionally, the company will be eligible for up to $120m in development and first commercial sales milestones per target. Immunome will also receive up to $70m in additional platform access payments based on AbbVie’s continued use of the Immunome platform.

Engineer 130

Engineer Antibody Drugs Immune Response 130

pharmaphorum

NOVEMBER 14, 2022

Sales of Dupixent rocketed 45% to around $2.4 Dupixent was cleared by the US FDA for adults with PN in September, making it an option for an estimated 75,000 patients with the condition, and adding to the drug’s earlier approvals in atopic dermatitis, asthma, chronic rhinosinusitis with nasal polyps, and eosinophilic oesophagitis.

Sales 118

Sales Immune Response Drugs Medicine 118

pharmaphorum

DECEMBER 4, 2020

Pfizer will pay up to $45 million in development related milestone payments and up to $143 million if the vaccine hits early sales targets. VLA15 has demonstrated a promising immune response and safety data in pre-clinical and clinical studies so far.

Vaccine 119

Vaccine Vaccination Bacterium Protein 119

XTalks

OCTOBER 11, 2024

The vaccine uses recombinant RSV glycoprotein F, stabilized in its prefusion conformation (RSVPreF3), along with GSK’s AS01E adjuvant to boost the immune response — the same adjuvant used in Shingrix, its shingles vaccine, but at a lower dose. This has reportedly led to a two-thirds drop in vaccine demand this season.

Vaccine 103

Vaccine Vaccination Immune Response Trials 103

pharmaphorum

AUGUST 10, 2021

The comments came on the German biotech’s second-quarter results call, during which BioNTech raised its forecasts for revenues it will book from sales of the vaccine to €15.9 billion in sales this year, although analysts have suggested this could be a conservative estimate. Pfizer said last month it may generate $33.5

Vaccine 116

Vaccine Vaccination Immune Response Sales 116

Pharmaceutical Technology

OCTOBER 28, 2022

What’s more, VAX-24 achieved a higher immune response to 16 of the 20 serotypes it shares with Prevnar 20. According to GlobalData, Pharmaceutical Technology’s parent company, Prevnar 13 and Vaxneuvance are forecasted to have global sales of $7.26 VAX-24 has forecasted sales of $21 million in the same year.

Vaccine 162

Vaccine Vaccination Marketing Bacteria 162

STAT News

NOVEMBER 3, 2022

… A Delaware federal court refused to throw out patent infringement claims brought by Arbutus Biopharma and Genevant Sciences against Moderna over its sale of Covid-19 vaccine doses to the U.S.  Genevant and Arbutus sued Moderna in February, seeking royalties from Moderna’s sale of its Covid-19 vaccine.

Vaccine 97

Vaccine Vaccination Drug Delivery Systems Sales 97

XTalks

JULY 28, 2021

billion in sales in 2020 and has been outselling Merck’s previous shot, Pneumovax 23, by almost five to one. While Merck’s previous shot, Pneumovax 23, defends against 23 serotypes and has been on the market for almost four decades, the immune responses it generates are not as durable as Prevnar 13.

FDA Approval 89

FDA Approval Vaccine Vaccination Immune Response 89

pharmaphorum

NOVEMBER 8, 2021

The results suggest that the REGEN-COV (casirivimab/imdevimab) antibody could play a key role in protecting people who do not mount a sufficiently strong immune response after COVID-19 vaccines, according to the company. That was down from almost $2.6

Antibody 105

Antibody Vaccine Vaccination Immune Response 105

XTalks

JUNE 21, 2024

According to a November 2023 readout, Capvaxive also elicited superior immune responses for ten of the 11 serotypes not covered by Prevnar 20. In 2023, Vaxneuvance, which was approved in 2021, netted $665 million in sales. Last year, sales of Pfizer’s pneumococcal vaccines reached $6.4

FDA Approval 108

FDA Approval Vaccine Vaccination Life Science 108

pharmaphorum

DECEMBER 6, 2022

Moderna is also suing Pfizer and BioNTech in Germany, and if it wins in both suits could claim a royalty on COVID-19 vaccine sales, although these have been falling and are expected to fall further if the pandemic continues to abate.

Vaccine 97

Vaccine Vaccination Immune Response Sales 97

pharmaphorum

AUGUST 5, 2022

It reckons that its antibodies will be able to target the underlying cause of autoimmune diseases, unlike current therapies such as steroids or TNF and interleukin inhibitors that while effective are non-selective, so suppress both appropriate and inappropriate immune responses.

Antibody 105

Antibody Immune Response Development Medicine 105

pharmaphorum

FEBRUARY 9, 2022

Closely related to this is the fact that global spending on oncology drugs reached $164 billion in 2020, with drug sales growing at a compound annual growth rate of 14.3% While therapeutic cancer vaccines are able to help the body identify particular proteins expressed by cancer cells and then to instigate an immune response.

Vaccine 134

Vaccine Vaccination Clinical Trials Clinical Trials 134

pharmaphorum

AUGUST 12, 2021

The AstraZeneca shot has been the mainstay of the UK vaccination and is provided at cost – just £2 per dose – although the drugmaker said last month that it was making a loss on sales due to high R&D costs. The Johnson & Johnson vaccine is also supplied on a no-profit basis.

Vaccine 111

Vaccine Vaccination Immune Response Sales 111

pharmaphorum

OCTOBER 2, 2020

Vaccibody, which is also entitled to tiered royalties on sales of any marketed products, will develop the DNA-based individualised neoantigen vaccines until the end of phase 1b. NEO, which is designed to be produced on-demand according to the neoantigen profile of an individual patient and produces an immune response that attacks the tumour.

Vaccine 59

Vaccine Vaccination Immune Response Drugs 59

XTalks

DECEMBER 12, 2024

Its the first FDA-cleared host-immune response assay for accurately distinguishing between bacterial and viral infections in just 15 minutes. MeMeds new Severity sepsis test also leverages advanced immunoassay technology to analyze specific host-response proteins to provide rapid, reliable results.

In-Vitro 92

In-Vitro Immune Response Protein Sales 92

XTalks

AUGUST 14, 2023

XTALKS WEBINAR: Cancer Immunotherapy: Exploring Imaging as a Catalyst to Immune Response Prediction Live and On-Demand: Wednesday, September 27, 2023, at 2pm EDT (11am PDT) Register for this free webinar to discover the present and transformative impact of predictive biomarkers on immunotherapy response.

FDA Approval 97

FDA Approval Antibody Immune Response Drugs 97

pharmaphorum

FEBRUARY 10, 2022

In its annual results statement, AZ said that it took the decision on the back of data showing that a third dose of Vaxzevria increased the immune response to new variants, including Omicron which is currently driving new COVID-19 cases around the world. ” Vaxzevria added almost $4 billion to its revenues last year, including $1.8

Vaccine 52

Vaccine Vaccination Development Immune Response 52

XTalks

JULY 8, 2021

Patients with severe COVID-19 often have an overactivation of the immune system, which involves the increased release of cytokines (cytokine release syndrome) such as IL-6. By blocking the cytokine from binding to its receptor, the hyperactive immune response can be tamed. Actemra sales reached $3.12

Doctors 98

Doctors Doctor Drugs Manufacturing 98

pharmaphorum

JANUARY 17, 2023

It launched a strategic review shortly afterwards, looking into a possible sale of the business, which was left with around $63 million in cash and liquid investments, and preclinical-stage ROCK2 and aldosterone synthase inhibitors. Darrell Irvine.

Immune Response 93

Immune Response Trials Engineer Sales 93

pharmaphorum

AUGUST 16, 2020

Last month, interim results from a phase 1/2 trial of ChAdOx1 were published in The Lancet and showed the jab was tolerated and generated immune responses against the SARS-CoV-2 virus in all vaccinated participants.

Vaccine 111

Vaccine Vaccination Immune Response Trials 111

Pharmaceutical Technology

FEBRUARY 13, 2023

GlobalData’s analyst consensus forecast database estimates peak annual sales for ARV-110 of $325 million in 2028. However, on-target adverse events are also common with BTKis as they inhibit B-cell immune responses, which can result in serious infections. with Calquence, 16% with Imbruvica, NCT02477696).

Development 147

Development Protein Immune Response Trials 147

pharmaphorum

SEPTEMBER 2, 2020

Jounce could also receive up to $685 million in future clinical, regulatory and commercial milestone payments, as well as royalties ranging from high single digit to mid-teens based upon worldwide sales, subject to certain adjustments. The company is perhaps better known for its lead candidate vopratelimab (previously known as JTX-2011).

Licensing 71

Licensing Licensing Antibody Immune Response 71

pharmaphorum

NOVEMBER 24, 2020

Sputnik V’s developers say its high level of efficacy comes from the use of two different adenoviral vectors which “allows for a stronger and longer-term immune response as compared to the vaccines using one and the same vector for two doses.”. The next analysis for Sputnik V will be made when there are 78 confirmed coronavirus cases.

Vaccine 111

Vaccine Vaccination Immune Response Marketing 111

pharmaphorum

SEPTEMBER 20, 2022

Though there is little question that sales generated in the area will come back to earth in the years to come, the industry’s outlook on the potential of vaccines and the infectious diseases area has been permanently shifted. This all comes down to the impact of the pandemic.

Vaccine 98

Vaccine Vaccination Immune Response Antibody 98

pharmaphorum

MARCH 17, 2022

After dosing, the LNPs deliver the mRNA sequence into cells, which is then used by cellular machinery to manufacture the viral protein and stimulate an immune response. Pfizer made $36 billion in sales from Comirnaty last year, and is expecting to shift another $32 billion-worth in 2022.

Vaccine 52

Vaccine Vaccination Sales Immune Response 52

pharmaphorum

JULY 14, 2021

The bulk of Prevnar 13 sales come from use in adults, and with Merck & Co in the final stages of regulatory review of its rival vaccine V114 – covering 15 serotypes and filed for adult use – the franchise is facing some serious competition for the first time. That is equivalent to 14% of Pfizer’s total revenues.

Immune Response 52

Immune Response Vaccine Vaccination Protein 52

pharmaphorum

DECEMBER 21, 2020

Each programme includes undisclosed upfront and milestone payments plus royalties on sales, with Merck indicating in a statement that it will be funding the research. Just a few weeks ago, Merck (known as MSD outside North America) paid $425 million to get hold of OncoImmune.

Immune Response 59

Immune Response Sales Antibody Drugs 59

pharmaphorum

AUGUST 26, 2022

Among the claims is that Comirnaty was developed using a chemical modification to prevent causing an unwanted immune response in patients which was discovered by Moderna scientists, and that the use of a lipid nanoparticle formulation also infringes its intellectual property.

Vaccine 59

Vaccine Vaccination Sales Immune Response 59

pharmaphorum

SEPTEMBER 29, 2022

The disorder – driven by type 2 inflammation characterised by an antibody-based immune response – causes hard lumps or nodules to form on the skin that are so itchy they can lead patients to scratch themselves to the point of bleeding or pain.

Drugs 69

Drugs Immune Response Allergies Sales 69

pharmaphorum

MAY 31, 2022

billion in sales last year. The pandemic and the timing of US government purchases for immunisation campaigns trimmed back sales from almost $5.9 The biotech says this can stimulate both B cell (antibody) and T cell immune responses with a single shot.

Vaccine 52

Vaccine Vaccination Bacterium Sales 52

XTalks

OCTOBER 25, 2022

The drug is approved in seven different types of cancer and the sales hit $2 billion in 2021 from $1.7 Fredrickson also said the target patient population for Imfinzi-Imjudo are patients who aren’t eligible to receive an anti-VEGF agent. billion in 2020, an increase of 20 percent.

FDA Approval 98

FDA Approval Trials Drugs Immune Response 98

The Pharma Data

JANUARY 22, 2021

An Ohio State University review of 49 vaccine studies dating back 30 years examined how stress, depression and healthy behaviors, such as exercise, can affect immune response to a vaccine. “What we see is that stress can delay your antibody response to the vaccine,” Kiecolt-Glaser said.

Immune Response 52

Immune Response Vaccine Vaccination Antibody 52

The Pharma Data

NOVEMBER 17, 2020

t for the treatment of autoimmune diseases , which occur when the body’s immune system attacks its own cells and tissues as foreign invaders. . While the antibody responsible for immune-mediated diseases is yet to be identified, they are thought to be regulated by an aberrant immune response. Source link.

Immune Response 52

Immune Response Licensing Licensing Sales 52

pharmaphorum

SEPTEMBER 8, 2021

Kadmon claimed approval for Rezurock (belumosudil) in July as a treatment for chronic graft versus host disease (GVHD) – a common and often fatal complication that can follow a bone marrow transplant and which occurs when the donated cells mount an immune response against the transplant recipient’s tissues and organs.

Drugs 52

Drugs Sales Immune Response Marketing 52

The Pharma Data

JANUARY 12, 2021

Ben-Moshe told BioSpace that BND-22 differs from traditional immunotherapy in that it can elicit a more total immune response. . “It It is a new immune checkpoint that is expressed on three different immune cells: Macrophages, [Natural Killer] NK cells, and T cells. [It]

Immune Response 52

Immune Response Clinical Trials Clinical Trials Development 52

pharmaphorum

JUNE 22, 2022

Merck also sells an older shot called Pneumovax 23, which covers 23 serotypes but is based on an older polysaccharide technology that does not stimulate the immune response as strongly as the newer conjugate vaccines. Sales dipped to $5.2 billion.

Vaccine 52

Vaccine Vaccination Immune Response Sales 52