Pharmaceutical Technology

OCTOBER 28, 2022

What’s more, VAX-24 achieved a higher immune response to 16 of the 20 serotypes it shares with Prevnar 20. According to GlobalData, Pharmaceutical Technology’s parent company, Prevnar 13 and Vaxneuvance are forecasted to have global sales of $7.26 VAX-24 has forecasted sales of $21 million in the same year.

Vaccine 162

Vaccine Vaccination Marketing Bacteria 162

STAT News

NOVEMBER 3, 2022

… A Delaware federal court refused to throw out patent infringement claims brought by Arbutus Biopharma and Genevant Sciences against Moderna over its sale of Covid-19 vaccine doses to the U.S.  Genevant and Arbutus sued Moderna in February, seeking royalties from Moderna’s sale of its Covid-19 vaccine.

Vaccine 97

Vaccine Vaccination Drug Delivery Systems Sales 97

XTalks

JULY 28, 2021

billion in sales in 2020 and has been outselling Merck’s previous shot, Pneumovax 23, by almost five to one. While Merck’s previous shot, Pneumovax 23, defends against 23 serotypes and has been on the market for almost four decades, the immune responses it generates are not as durable as Prevnar 13.

FDA Approval 89

FDA Approval Vaccine Vaccination Immune Response 89

pharmaphorum

DECEMBER 6, 2022

Moderna is also suing Pfizer and BioNTech in Germany, and if it wins in both suits could claim a royalty on COVID-19 vaccine sales, although these have been falling and are expected to fall further if the pandemic continues to abate.

Vaccine 97

Vaccine Vaccination Immune Response Sales 97

pharmaphorum

AUGUST 5, 2022

It reckons that its antibodies will be able to target the underlying cause of autoimmune diseases, unlike current therapies such as steroids or TNF and interleukin inhibitors that while effective are non-selective, so suppress both appropriate and inappropriate immune responses.

Antibody 105

Antibody Immune Response Development Medicine 105

pharmaphorum

FEBRUARY 9, 2022

Closely related to this is the fact that global spending on oncology drugs reached $164 billion in 2020, with drug sales growing at a compound annual growth rate of 14.3% While therapeutic cancer vaccines are able to help the body identify particular proteins expressed by cancer cells and then to instigate an immune response.

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Vaccine Vaccination Clinical Trials Clinical Trials 134

pharmaphorum

AUGUST 12, 2021

The AstraZeneca shot has been the mainstay of the UK vaccination and is provided at cost – just £2 per dose – although the drugmaker said last month that it was making a loss on sales due to high R&D costs. The Johnson & Johnson vaccine is also supplied on a no-profit basis.

Vaccine 111

Vaccine Vaccination Immune Response Sales 111

pharmaphorum

OCTOBER 2, 2020

Vaccibody, which is also entitled to tiered royalties on sales of any marketed products, will develop the DNA-based individualised neoantigen vaccines until the end of phase 1b. NEO, which is designed to be produced on-demand according to the neoantigen profile of an individual patient and produces an immune response that attacks the tumour.

Vaccine 59

Vaccine Vaccination Immune Response Drugs 59

pharmaphorum

FEBRUARY 10, 2022

In its annual results statement, AZ said that it took the decision on the back of data showing that a third dose of Vaxzevria increased the immune response to new variants, including Omicron which is currently driving new COVID-19 cases around the world. ” Vaxzevria added almost $4 billion to its revenues last year, including $1.8

Vaccine 52

Vaccine Vaccination Development Immune Response 52

pharmaphorum

JANUARY 17, 2023

It launched a strategic review shortly afterwards, looking into a possible sale of the business, which was left with around $63 million in cash and liquid investments, and preclinical-stage ROCK2 and aldosterone synthase inhibitors. Darrell Irvine.

Immune Response 93

Immune Response Trials Engineer Sales 93

pharmaphorum

AUGUST 16, 2020

Last month, interim results from a phase 1/2 trial of ChAdOx1 were published in The Lancet and showed the jab was tolerated and generated immune responses against the SARS-CoV-2 virus in all vaccinated participants.

Vaccine 111

Vaccine Vaccination Immune Response Trials 111

Pharmaceutical Technology

FEBRUARY 13, 2023

GlobalData’s analyst consensus forecast database estimates peak annual sales for ARV-110 of $325 million in 2028. However, on-target adverse events are also common with BTKis as they inhibit B-cell immune responses, which can result in serious infections. with Calquence, 16% with Imbruvica, NCT02477696).

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Development Protein Immune Response Trials 147

pharmaphorum

SEPTEMBER 2, 2020

Jounce could also receive up to $685 million in future clinical, regulatory and commercial milestone payments, as well as royalties ranging from high single digit to mid-teens based upon worldwide sales, subject to certain adjustments. The company is perhaps better known for its lead candidate vopratelimab (previously known as JTX-2011).

Licensing 71

Licensing Licensing Antibody Immune Response 71

pharmaphorum

NOVEMBER 24, 2020

Sputnik V’s developers say its high level of efficacy comes from the use of two different adenoviral vectors which “allows for a stronger and longer-term immune response as compared to the vaccines using one and the same vector for two doses.”. The next analysis for Sputnik V will be made when there are 78 confirmed coronavirus cases.

Vaccine 111

Vaccine Vaccination Immune Response Marketing 111

pharmaphorum

MARCH 17, 2022

After dosing, the LNPs deliver the mRNA sequence into cells, which is then used by cellular machinery to manufacture the viral protein and stimulate an immune response. Pfizer made $36 billion in sales from Comirnaty last year, and is expecting to shift another $32 billion-worth in 2022.

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Vaccine Vaccination Sales Immune Response 52

pharmaphorum

DECEMBER 21, 2020

Each programme includes undisclosed upfront and milestone payments plus royalties on sales, with Merck indicating in a statement that it will be funding the research. Just a few weeks ago, Merck (known as MSD outside North America) paid $425 million to get hold of OncoImmune.

Immune Response 59

Immune Response Sales Antibody Drugs 59

pharmaphorum

AUGUST 26, 2022

Among the claims is that Comirnaty was developed using a chemical modification to prevent causing an unwanted immune response in patients which was discovered by Moderna scientists, and that the use of a lipid nanoparticle formulation also infringes its intellectual property.

Vaccine 59

Vaccine Vaccination Sales Immune Response 59

pharmaphorum

MAY 31, 2022

billion in sales last year. The pandemic and the timing of US government purchases for immunisation campaigns trimmed back sales from almost $5.9 The biotech says this can stimulate both B cell (antibody) and T cell immune responses with a single shot.

Vaccine 52

Vaccine Vaccination Bacterium Sales 52

The Pharma Data

NOVEMBER 17, 2020

t for the treatment of autoimmune diseases , which occur when the body’s immune system attacks its own cells and tissues as foreign invaders. . While the antibody responsible for immune-mediated diseases is yet to be identified, they are thought to be regulated by an aberrant immune response. Source link.

Immune Response 52

Immune Response Licensing Licensing Sales 52

The Pharma Data

JANUARY 12, 2021

Ben-Moshe told BioSpace that BND-22 differs from traditional immunotherapy in that it can elicit a more total immune response. . “It It is a new immune checkpoint that is expressed on three different immune cells: Macrophages, [Natural Killer] NK cells, and T cells. [It]

Immune Response 52

Immune Response Clinical Trials Clinical Trials Development 52

pharmaphorum

SEPTEMBER 15, 2020

The hope is that directly targeting the cells lining the airways may stimulate a more effective immune response against SARS-CoV-2. In the trial, the two vaccines will be delivered to the lungs via a nebuliser.

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Vaccine Vaccination Immune Response Manufacturing 80

Delveinsight

AUGUST 26, 2021

Under the agreement, Shape is eligible to receive an initial payment and payments for hitting development, regulatory and sales milestones potentially exceeding USD 3 billion in aggregate value. Researchers will compare the two-time points to recognize the optimum timing of peak immune response following nasal vaccination.

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Vaccine Vaccination Gene Therapy RNA 98

The Pharma Data

JANUARY 12, 2021

“The T-cell and NK-cell target discovery approach complements our portfolio aimed at turning cold tumors hot and redirecting the innate immune system to elicit a sustained and durable immune response against tumors. KSQ is also eligible to receive tiered royalties on net sales of each approved product.

Development 52

Development Research In-Vivo Genome 52

Pharmaceutical Technology

APRIL 24, 2023

With early nanoparticle studies, researchers often found the human body’s innate immune response to drugs and the short-lasting effects of drugs challenging, as they can also reduce a drug’s efficacy. billion in Spikevax sales in 2022, and Comirnaty generating $37 million for Pfizer in 2022.

Drug Delivery 147

Drug Delivery Vaccine Vaccination Research 147

pharmaphorum

FEBRUARY 14, 2022

billion in sales last year, slightly down as a result of the pandemic. Like Shingrix, CRV-101 is a subunit vaccine based on the glycoprotein E (gE) antigen of the herpes zoster virus, delivered alongside an adjuvant to boost the immune response.

Vaccine 52

Vaccine Vaccination Immune Response Trials 52

pharmaphorum

SEPTEMBER 30, 2021

Prevnar 20 was approved in June, and provides protection against 20 pneumococcal serotypes, seven more than the current Prevnar 13 shot that made almost $6 billion in sales for Pfizer last year, dominating a market worth around $8 billion. Vaxneuvance – which targets 15 serotypes – is key to Merck’s plan to boost market share.

Vaccine 52

Vaccine Vaccination Immune Response Marketing 52

pharmaphorum

JANUARY 4, 2023

They both also include tiered royalties on sales of any products emerging from the partnerships. The hypothesis is that it will induce immune tolerance by stimulating anti-inflammatory regulatory T- (Treg) cells and cytokines that dampen down the immune response.

Immune Response 52

Immune Response Engineer Licensing Licensing 52

pharmaphorum

JANUARY 5, 2021

First-line immunotherapy for NSCLC is dominated by Merck & Co’s PD-1 inhibitor Keytruda (pembrolizumab), transforming the prospects of some patients and propelling the drug to multibillion-dollar sales.

Immune Response 52

Immune Response FDA Approval Drugs Sales 52

The Pharma Data

JANUARY 18, 2021

Next Generation AAVs enhance gene therapies by increasing transduction efficiency and specificity while reducing immune responses and cost. In addition, Neurophth will pay AAVnerGene royalties for the sales of any resulting commercialized gene therapy. WUHAN, China and NEWARK, DE. ,

Gene Therapy 52

Gene Therapy Gene Immune Response Manufacturing 52

Delveinsight

SEPTEMBER 8, 2021

Benlysta Sales and Annual cost of therapy (ACOT). As per DelveInsight’s report on Benlysta (Belimumab) market forecast , the sale of Belimumab has kept on increasing year after year. In 2017, the total sale of Belimumab was USD 119 million across all three regions (the United States, Europe, and International).

Marketing 52

Marketing Sales FDA Approval Antibody 52

The Pharma Data

OCTOBER 27, 2020

Mirati will not receive any proceeds from the sale of common stock by the selling stockholder. Sitravatinib is an investigational spectrum-selective inhibitor of receptor tyrosine kinases (RTK) designed to enhance immune responses through the inhibition of immunosuppressive signaling.

Sales 52

Sales Immune Response Clinical Development Development 52

The Pharma Data

DECEMBER 23, 2020

All 38 subjects who were evaluable for immunogenicity had balanced cellular and humoral immune responses following the second dose of INO-4800. The antigen is processed naturally in the cell and triggers the desired T cell and antibody-mediated immune responses. About INOVIO.

DNA 40

DNA Vaccination Vaccine Immune Response 40

XTalks

MARCH 8, 2024

According to Amgen’s last earnings report , Prolia sales increased 12 percent last year to more than $4 billion, and Xgeva’s jumped five percent from last year to $2.1 Amgen also claimed that Sandoz failed to provide information about its biosimilar manufacturing process as required by law.

Drugs 59

Drugs FDA Approval Production Immune Response 59

The Pharma Data

JANUARY 19, 2021

The company’s focus is on the development, manufacture, marketing and sale of licorice products, oxytetracycline products, traditional Chinese medicine derivatives, heparin, sausage casing, and fertilizers. This is planned to raise about $25 million. Neximmune – The company filed for an IPO to raise $86 million on January 19.

In-Vitro 52

In-Vitro Production Trials Manufacturing 52

The Pharma Data

NOVEMBER 9, 2020

Amgen will record sales in the U.S. and AstraZeneca will record sales in Canada. Amgen will record sales as collaboration revenue. TSLP is released in response to multiple triggers associated with asthma exacerbations, including allergens, viruses and other airborne particles. Outside the U.S.,

Trials 52

Trials Production Sales Manufacturing 52

The Pharma Data

OCTOBER 21, 2020

This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities, in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

Gene Therapy 40

Gene Therapy Immune Response Sales Gene 40

The Pharma Data

DECEMBER 21, 2020

Amgen will record sales in the U.S. and AstraZeneca will record sales in Canada. Amgen will record sales as collaboration revenue. TSLP is released in response to multiple triggers associated with asthma exacerbations, including allergens, viruses and other airborne particles. Outside the U.S.,

Trials 40

Trials Production Sales Manufacturing 40