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Researchers reverse the in vitro and in vivo effects of the mutation that causes Stormorken syndrome

Medical Xpress

That was the case when Thilini Gamage was to carry out one of the studies in her doctoral work with Professor Eirik Frengen at the Institute of Clinical Medicine, University of Oslo. They study gene variation and mutations that cause rare genetic diseases. A mutation is a permanent change in the genetic material.

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China’s NMPA clears Transcenta’s IND for solid tumour treatment

Pharmaceutical Technology

A synergistic activity was also observed between the anti-Gremlin1 antibody and enzalutamide against castration-resistant prostate cancer models derived from patients in vitro and in vivo. TST003 is a first-in-class Gremlin1 targeting humanised monoclonal antibody.

Antibody 242
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Oncotarget: mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC

Scienmag

Oncotarget published “High in vitro and in vivo synergistic activity between mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC” which reported that the aim of […].

In-Vivo 96
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Aevitas to sell sCFH asset rights to 4D Molecular

Pharmaceutical Technology

sCFH is an engineered and improved version of complement factor H (CFH) that can fit into adeno-associated virus (AAV) vectors with solid expression and applications confirmed in cultured human cells in vitro, in addition to various preclinical animal models in vivo. The firm will also receive single-digit royalties on net sales.

In-Vivo 130
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Digital therapeutics: a new frontier of medicine

pharmaphorum

For example, there is no need for in vivo animal or in vitro pre-clinical or non-clinical studies. The area of digital therapeutics is growing rapidly, and in this piece Ben Hargreaves examines why this is the case, how broadly these therapies can be applied and why investment in the area is mounting. This equated to $21.3

Medicine 111
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Merck will assess Quris’ AI ‘patient-on-a-chip’ drug safety

pharmaphorum

Quris’ BioAI safety prediction platform – which is based on human tissue samples on chips, nanosensors and machine learning – will be compared to traditional in vitro and in vivo laboratory techniques for spotting toxicity.

Drugs 98
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Could CRISPR cure HIV? US biotech Excision raises $60m to find out

pharmaphorum

Excision is co-founded by Kamel Khalili, chair of Temple University’s neuroscience department and director of the institution’s Comprehensive NeuroAIDS Centre at the Lewis Katz School of Medicine. We have proven the technology and candidate programs in vitro and in vivo in both small animal models and primate models.