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China’s NMPA clears Transcenta’s IND for solid tumour treatment

Pharmaceutical Technology

Findings from a study, which was conducted by Transcenta and Shanghai Jiao Tong University scientists on TST003 to treat androgen receptor-negative/low prostate cancer, were published by Nature Cancer in May last year. TST003 is a first-in-class Gremlin1 targeting humanised monoclonal antibody.

Antibody 242
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Researchers reverse the in vitro and in vivo effects of the mutation that causes Stormorken syndrome

Medical Xpress

Sometimes scientists arrive at new findings and discoveries by chance. That was the case when Thilini Gamage was to carry out one of the studies in her doctoral work with Professor Eirik Frengen at the Institute of Clinical Medicine, University of Oslo. They study gene variation and mutations that cause rare genetic diseases.

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ProPhase and Dana-Farber Cancer Institute partner for LB-1 development

Pharmaceutical Technology

The collaboration project will evaluate the tumoricidal effects in an orthotopic mouse model and the advantages of LB-1 in-vivo nanoparticle-based administration. The collaboration project will evaluate the tumoricidal effects in an orthotopic mouse model and the advantages of LB-1 in-vivo nanoparticle-based administration.

In-Vivo 130
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#news #biotech Scientists discover dynamic trimolecular G-quadruplex

BioTech 365

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Scientists discover dynamic trimolecular G-quadruplex.As

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How PK Modeling Can Inform Sample Size Estimation and Dose Selection for Your Product

Camargo

Drug development is an extremely cumbersome process, requiring the testing of an agent from in vitro studies to in vivo studies to in silico modeling. Given that it can take up to 20 years for a final product to be approved, it is unsurprising that drug attrition rates are very high. Approaches to Pharmacokinetic Analysis.

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Receptor Occupancy Assays by Flow Cytometry: Benefits for Clinical Trials

XTalks

Both the areas of drug development and clinical trials are increasingly using in vitro assays to help determine the efficacy of an investigational therapeutic. Flow cytometric receptor occupancy assays are being increasingly used in preclinical and clinical studies. What is Flow Cytometry?

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Transitioning Between Academia and Industry: Advice from Leading Scientists That Made the Switch

XTalks

Leaving academia for industry is a route that academic scientists and professors did not traditionally pursue in the past due to perceived differences in skillsets, experiences and even associated stigmas. WeiQi Lin, MD, PhD, executive vice president of research & development and principal scientist, DURECT Corporation.