XTalks

JUNE 14, 2024

Ontario, Canada’s largest province by population, is stepping up its commitment to the life sciences sector with an investment of $40 million. The $40 million will come from the Venture Ontario Fund, which is dedicated to helping Ontario life sciences companies and biomanufacturers innovate, grow and compete in global markets.

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XTalks

JULY 27, 2022

Toleikis spoke about the latest clinical trial data for the medical device, and also about the company’s new partnership with Evotec to integrate its insulin-producing cells in the Cell Pouch System. Subscribe to the Xtalks Life Science Podcast to never miss a new episode.

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XTalks

SEPTEMBER 15, 2020

A vaccine developed by Swedish company Diamyd Medical has demonstrated significant treatment efficacy in a predefined genetic subgroup of individuals with type 1 diabetes in a Phase IIb clinical trial. In the trial, the vaccine was injected directly into the lymph nodes of type 1 diabetic individuals. The DIAGNODE-2 Trial.

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XTalks

DECEMBER 11, 2024

The companys lead innovation is an implantable bio-hybrid organ pouch, which is currently in an ongoing Phase I/II clinical trial. Prior to heading Sernova, Jonathan served as President and CEO of Revolo Biotherapeutics where he took the company through multiple financings and two Phase II clinical trials.

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XTalks

SEPTEMBER 2, 2020

NAFLD is part of the metabolic syndrome that is characterized by diabetes, or pre-diabetes (insulin resistance), which includes being overweight or obese, elevated blood lipids such as cholesterol and triglycerides, as well as high blood pressure. VK2809 and the VOYAGE Trial. NASH may result in severe liver scarring and cirrhosis.

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XTalks

MARCH 17, 2025

billion, primarily linked to initiating Phase III trials for petrelintide as a stand-alone therapy, with sales-based milestones that could push the total value to $5.3 Amylin, a hormone co-secreted with insulin, plays a key role in regulating appetite by enhancing leptins effects the hormone that signals fullness after eating.

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XTalks

NOVEMBER 23, 2022

Ayesha also talked about the latest positive Phase III trial data that Pfizer recently shared for its maternal RSV vaccine candidate. Hear more about the vaccine trial data, based on which an independent data monitoring committee has recommended that Pfizer file with the FDA for approval.

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XTalks

NOVEMBER 22, 2022

In clinical trials, the treatment delayed stage 3 disease onset for about two years compared with the placebo. Type 1 diabetes, also known as insulin-dependent or juvenile diabetes, is an autoimmune disease that occurs when the body is unable to make enough insulin due to destruction of the beta insulin-producing cells in the pancreas.

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XTalks

APRIL 29, 2022

Eli Lilly announced that its obesity drug tirzepatide has scored favorably in a late-stage clinical trial, with results showing that people who took the drug lost an average of 50 pounds, or 21 percent, of their body weight compared to placebo. percent and 22.5 percent, respectively, compared to placebo.

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XTalks

MARCH 8, 2021

Eli Lilly (NASDAQ: LLY ) reported late last week that its investigational diabetes injection, tirzepatide, demonstrated superiority to Novo Nordisk’s (NASDAQ: NVO ) ozempic (semaglutide) in a Phase III trial. GLP-1 receptor agonists lower blood glucose levels by increasing the production of insulin. SURPASS-2 Clinical Trial.

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XTalks

APRIL 29, 2021

Multiple studies have confirmed that conducting clinical trials with a diverse range of ethnicities, genders, ages, and lifestyles is essential, since these factors can impact a treatment’s effectiveness among different groups. Despite this, ethnic minorities are underrepresented in clinical trials.

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XTalks

SEPTEMBER 17, 2020

In rare disease trials, it’s not always feasible to choose clinically-relevant endpoints to measure the efficacy of a new therapeutic. IGF-1 is an acceptable surrogate endpoint in trials of growth hormone receptor agonists like Somavert, and is preferred for pediatric patient populations.

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XTalks

DECEMBER 13, 2024

Zealand Pharma has commenced its global Phase IIb ZUPREME-1 trial, enrolling the first participant to evaluate petrelintide, a long-acting amylin analog, as a potential investigational treatment for people with overweight or obesity. And among its many obesity drugs in clinical trials, Eli Lillys amylin analog eloralintide is in Phase II.

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XTalks

JULY 17, 2024

Sweden-based biotech Camurus shared positive Phase III trial data for CAM2029, one of its lead candidates, in patients with the rare hormonal disorder acromegaly. Octreotide is a synthetic analog of somatostatin, a hormone in the body that inhibits the release of several other hormones, including growth hormone (GH), glucagon and insulin.

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XTalks

NOVEMBER 9, 2022

Lilly is also working towards an obesity treatment form of tirzepatide, with trials currently underway to evaluate its weight loss effects. GLP-1 receptor agonists, or incretin (metabolic hormones) mimetics, are analogs of the GLP-1 peptide hormone that binds to the GLP-1 receptor to regulate blood sugar levels by boosting insulin secretion.

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XTalks

APRIL 22, 2022

Both the areas of drug development and clinical trials are increasingly using in vitro assays to help determine the efficacy of an investigational therapeutic. In a recent webinar, Dr. Olsson described the benefits of flow cytometric receptor occupancy assays in clinical trials. The Benefits of Receptor Occupancy in Clinical Trials.

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XTalks

DECEMBER 15, 2022

In September 2021, the US Food and Drug Administration (FDA) issued a partial US clinical hold on the phase III DIAGNODE-3 clinical trial of the drug. After over a year, on November 27 this year Diamyd Medical announced that the US FDA lifted the clinical hold on DIAGNODE-3, giving the company a green light to commence the trial in the US.

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XTalks

JULY 15, 2024

The drug has been evaluated in five clinical trials for PBH. Congenital HI is a genetic disorder that causes excessive insulin production by the pancreas, which lowers plasma or blood sugar. This action helps mitigate hypoglycemia by reducing insulin secretion and stabilizing glucose levels.

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XTalks

JULY 15, 2024

The drug has been evaluated in five clinical trials for PBH. Congenital HI is a genetic disorder that causes excessive insulin production by the pancreas, which lowers plasma or blood sugar. This action helps mitigate hypoglycemia by reducing insulin secretion and stabilizing glucose levels.

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Insulin Drugs Life Science Marketing 52

Pharmaceutical Technology

JANUARY 31, 2023

Inflation Reduction Act Speaking during the keynote panel “FDA & ARPA-H: Life Sciences, Biopharma & Medtech Priorities in a New Year”, Califf discussed the Inflation Reduction Act of August 2022, which aims to lower prescription drug prices. But then, “you should have to prove it.

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XTalks

JUNE 3, 2021

The study , published yesterday in the Endocrine Society’s Journal of Clinical Endocrinology and Metabolism , revealed that two helpings of fruit led to higher measures of insulin sensitivity than those who ate less than half a serving. Diabetes is a growing health problem globally. Keep it Fresh.

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XTalks

FEBRUARY 8, 2021

Last year, Biocon Biologics and Mylan announced they’d be seeking interchangeable status for their long-acting insulin product Semglee , developed to be an alternative to Sanofi’s Lantus (insulin glargine). MYTH: Treatment-experienced patients cannot be prescribed biosimilars.

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XTalks

SEPTEMBER 22, 2020

The study investigators conducted a post-hoc analysis of data from the Phase III CANVAS Clinical Trial Program. Compared to other anti-diabetic drugs, such as sulfonylurea derivatives and insulin, SGLT2 inhibitors are associated with a low risk of hypoglycaemia. Related: New Drug Treatment Shows Efficacy for Lupus Kidney Disease.

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Trials Clinical Trials Clinical Trials Insulin 95

XTalks

FEBRUARY 8, 2024

Diabetes remains a critical global challenge, affecting millions of lives and commanding significant attention from the medical, life sciences and pharmaceutical sectors. In its 2022 financial report, Sanofi reported that sales of the long-acting insulin dropped 27.6 percent in the fourth quarter and decreased 56.7 from $289.36.

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XTalks

FEBRUARY 6, 2024

Revita, an outpatient endoscopic procedural therapy, which aims to eliminate insulin needs and enhance glycemic control by ablating dysfunctional duodenal mucosa. Another noteworthy candidate, ALTO-100, also demonstrates efficacy and favorable safety in patients with post-traumatic stress disorder (PTSD) in its Phase II trial.

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Gene Therapy Gene Clinical Trials Clinical Trials 98

XTalks

NOVEMBER 3, 2022

Mounjaro was approved this summer as a Type 2 diabetes treatment and is the first diabetes drug with dual action, targeting two hormones involved in insulin production and appetite (GIP and GLP-1). In contrast, Novo’s diabetes drugs Ozempic and Rybelsus (both semaglutide) are just GLP-1 agonists.

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XTalks

MAY 13, 2021

Its latest ad campaign, “Wake Up to the Possibilities” set to the backdrop of Simon Ravenhall’s song “You Are My Sunshine,” boasts about the possibilities of lowering blood sugar for type 2 diabetics through a trifecta of increasing insulin, decreasing glycogen breakdown in the liver and slowing digestion. Eli Lilly spent $14.7

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XTalks

FEBRUARY 21, 2024

Recently, Eli Lilly revealed promising results from a mid-stage trial, indicating that its popular drug, tirzepatide (marketed as Zepbound and Mounjaro for weight loss and diabetes, respectively), may be an effective treatment for the fatty liver disease metabolic dysfunction-associated steatohepatitis (MASH).

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XTalks

JUNE 10, 2024

The study explored efruxifermin’s potential in reducing liver fat, reversing fibrosis, enhancing insulin sensitivity and improving lipid profiles, representing a comprehensive treatment strategy for MASH. It not only reduces liver fat and inflammation but can also reverse fibrosis, enhance insulin sensitivity and improve lipid profiles.

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XTalks

AUGUST 2, 2023

This is largely due to failed trials as a prophylaxis resulting in the European Committee for Medical Products (CHMP) recommending against the approval of Lagevrio. It is a dipeptidyl peptidase-4 inhibitor that keeps insulin levels stable and reduces the amount of glucose produced by the body. billion in 2022. billion ($8.72

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XTalks

JANUARY 25, 2023

Brenzavvy’s approval was based on an impressive amount of data collected from 23 clinical trials involving over 5,000 patients with type 2 diabetes. TheracosBio will thus be going up against some major market competition.

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XTalks

SEPTEMBER 20, 2023

Its approval in January 2023 was grounded in an extensive clinical program comprising 23 trials that enrolled over 5,000 adults diagnosed with type 2 diabetes mellitus. The dosing regimen for Brenzavvy involves a single 20 mg tablet taken each morning. A 30-day supply of Brenzavvy through Cost Plus Drugs is $47.85, plus shipping and handling.

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XTalks

AUGUST 17, 2020

With several biologics in the pipeline, including one in early stage clinical trials for head and neck cancer, the company is positioned to engineer highly specific biologics against immune targets in the body. The starting dose of CUE-101 in the clinical trial was quite low (60 µg/kg). Cell-Based Immunotherapy vs. Immune Biologics.

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XTalks

JUNE 12, 2023

Medtronic’s proactive stance towards R&D is evident from the over 230 clinical trials it conducted and the more than 200 regulatory approvals it received in the US, Europe, Japan and China in the 2022 fiscal year. Internationally, Medtronic expanded its MiniMed 780G insulin pump and Guardian 4 sensor.

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XTalks

DECEMBER 3, 2024

From blockbuster drugs like Ozempic to foundational treatments like insulin, these therapies showcase the diverse strategies used by pharma companies to meet the needs of a rapidly growing market. Price of Insulin: Varies significantly by type and brand of insulin. The approval for higher doses (3.0 mg and 4.5 billion to $41.6

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XTalks

FEBRUARY 24, 2025

They recently presented positive 36month primary endpoint findings from the OPTION trial demonstrating superior bleeding risk reduction with the WATCHMAN FLX Left Atrial Appendage Closure. Boston Scientific (BSX) Boston Scientific, a global innovator in interventional medical devices, reported net sales of $4.56 billion for 2024.

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Marketing Sales Insulin Manufacturing 66

XTalks

MAY 20, 2022

Life science industry data analytics company Evaluate Vantage predicts that Mounjaro could bring in $4.9 Related: Tirzepatide Obesity Drug Shown to Reduce Body Weight by 20 Percent in Eli Lilly Trial. The efficacy of Mounjaro was compared to placebo, Novo Nordisk’s semaglutide and two long-acting insulin analogs.

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