Pharmaceutical Technology

APRIL 28, 2023

The drug is based on protein acylation technology and works to reduce blood sugar by enhancing glucose-dependent insulin secretion from the pancreas, as well as reducing glucagonemia and body weight. This represents a significant 83% increase in sales between 2022–2029, demonstrating a compound annual growth rate (CAGR) of 9%.

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BioPharma Reporter

MAY 3, 2023

Protein drugs are notoriously difficult to deliver orally â but scientists have developed a new type of oral capsule that could deliver insulin and other similar drugs.

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Pharmaceutical Technology

JUNE 29, 2022

Specialty enzymes are proteins that can act as very specific biocatalysts to accelerate reactions and produce the desired target molecule in pharmaceuticals,” explains Kristoffer Laursen, Head of R&D at Novo Nordisk Pharmatech. “In In the evolving biotechnology industry, enzymes are important process aids.

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Scienmag

JUNE 13, 2022

Researchers at Karolinska Institutet in Sweden show how a molecule that they have identified stimulates the formation of new insulin-producing cells in zebrafish and mammalian tissue, through a newly described mechanism for regulating protein synthesis. The results are published in Nature Chemical Biology.

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Scienmag

MAY 17, 2022

Well known for their applications in the production of therapeutic proteins like insulin, plasmids are broadly used in the large-scale production of many bioproducts. These small, circular DNA molecules are used by scientists to introduce new genes into a target organism. Credit: CABBI Plasmids have extensive […].

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Camargo

NOVEMBER 29, 2021

Recombinant therapeutic proteins. Fusion proteins. They may contain proteins that control the action of other proteins and cellular processes, genes that control production of vital proteins, modified human hormones, or cells that produce substances that suppress or activate components of the immune system.

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FDA Law Blog

AUGUST 12, 2021

On July 30, 2021, FDA approved Semglee (insulin glargine-yfgn), an insulin product that relies on Lantus (insulin glargine) as its reference product. So, it remains to be seen if and when interchangeable Semglee will have any meaningful effect on insulin prices in the near future.

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Roots Analysis

SEPTEMBER 9, 2024

Over the years, pharmaceutical companies have shifted their priorities from traditional interventions towards more advanced pharmacological strategies, such as protein therapeutics. Further, $400 billion is the anticipated sales of protein-based therapeutics in 2023. The mRNA is then translated into to form functional proteins.

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Delveinsight

AUGUST 18, 2021

In Type 2 diabetes, the body cells become resistant to insulin. The pancreas produces insulin that helps glucose get into cells to be used for energy. Due to Type 2 diabetes, either the body doesn’t make enough insulin or it doesn’t use insulin properly as a result the blood glucose or blood sugar gets too high.

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XTalks

SEPTEMBER 15, 2020

In addition to the vaccine, the company is also developing an investigational drug called Remygen for the regeneration of endogenous insulin production and to improve hormonal response to hypoglycemia; trials to test the treatment are currently ongoing in patients that have been living with type 1 diabetes for more than five years.

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pharmaphorum

FEBRUARY 28, 2022

Biocon’s partnership with Mylan – which merged with Pfizer’s Upjohn to form Viatris in 2020 – dates back more than a decade and has generated a number of biosimilars including insulin analogues, antibodies and recombinant proteins.

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The Pharma Data

JULY 15, 2021

Protomer’s proprietary peptide- and protein-engineering platform is used to identify and synthesize molecules that can sense glucose or other endogenous modulators of protein activity. Eli Lilly and Company (NYSE: LLY) today announced the acquisition of Protomer Technologies (“Protomer”), a private biotech company.

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Velocity Clinical Research

JUNE 27, 2023

Rosenstock is the lead investigator for Novo Nordisk’s ONWARDS 1 program exploring the first investigational once-weekly insulin. “In In ONWARDS 1, insulin icodec allowed people to spend significantly more Time in Range, with comparable Time below Range vs. once-daily basal insulin glargine U100,” said Dr. Rosenstock. “A

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The Pharma Data

MARCH 3, 2022

Patients taking the oral blood pressure medication not only required less daily insulin two years after first diagnosis of the disease, but also showed evidence of surprising immunomodulatory benefits. Type 1 diabetes is an autoimmune disease that causes loss of pancreatic beta cells, which produce endogenous insulin.

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XTalks

AUGUST 17, 2020

protein-based biologics) and vaccine treatments. protein-based biologics) : are those which bind to specific components (i.e. A growing area in the immunotherapy space is the development of biological modulators, which are genetically engineered proteins that target specific components of the immune system.

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XTalks

FEBRUARY 8, 2021

They include proteins, monoclonal antibodies and vaccines that are considered to be “ highly similar ” to biological products that have already been approved by the FDA. Significantly, insulin was deemed to be a biologic as of March 23, 2020, making it a reference product for the development of biosimilar versions.

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XTalks

FEBRUARY 8, 2024

for a one-month supply Why it did so well: Jardiance belongs to a class of drugs known as sodium-glucose co-transporter 2 (SGLT2) inhibitors, inhibiting the SGLT2 protein in the kidneys to lead to the excretion of excess glucose through the urine. In its 2022 financial report, Sanofi reported that sales of the long-acting insulin dropped 27.6

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The Pharma Data

DECEMBER 1, 2020

Compared with HDG, the green Mediterranean diet group achieved a greater decrease in low-density lipoprotein cholesterol (LDL-C), diastolic blood pressure, and insulin resistance at six months. Gal Tsaban, M.D., The researchers found that both Mediterranean diets achieved similar weight loss (green Mediterranean, ?6.2 kg; Mediterranean, ?

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XTalks

SEPTEMBER 22, 2020

It is an inhibitor of subtype 2 sodium-glucose transport proteins (SGLT2), which functions in glucose reabsorption. Compared to other anti-diabetic drugs, such as sulfonylurea derivatives and insulin, SGLT2 inhibitors are associated with a low risk of hypoglycaemia.

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Delveinsight

DECEMBER 10, 2020

Warding off Type 1 diabetes by aiming a T-cell protein. The body’s immune system falsely attacks insulin-making beta cells in the pancreas in Type 1 diabetes. Scientists at the University of Utah School of Medicine have found a way to control that autoimmune response by aiming a protein that is vital for T-cell activation.

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The Pharma Data

DECEMBER 31, 2020

People with severe COVID-19 have low proportions of antibodies that target the spike protein. In milder cases, the antibodies seem to do a better job of binding to the spike protein. The spike protein binds to the ACE2 receptor on human cells, which allows the virus to enter the cell.

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The Pharma Data

FEBRUARY 1, 2021

. “Metformin can improve insulin sensitivity and correct high insulin levels by reducing the amount of insulin and insulin-like growth factor circulating in the body, which may activate cell signals involved in cancer,” Sandler said.

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XTalks

JUNE 10, 2024

Efruxifermin is a novel Fc-FGF21 fusion protein designed to emulate the activity of native FGF21, an endogenous hormone that regulates metabolism and alleviates cellular stress. It not only reduces liver fat and inflammation but can also reverse fibrosis, enhance insulin sensitivity and improve lipid profiles.

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Delveinsight

DECEMBER 7, 2020

The test identifies Ubiquitin and Glial Fibrillary Acidic Protein (GFAP)- 2 brain-specific protein biomarkers- that appear rapidly in the blood of a patient after a brain injury. The device is worn on the patients’ body, which contains a biharmonic cartridge in it that carries insulin and glucagon.

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Roots Analysis

JANUARY 14, 2024

Biologics activate certain proteins or cells in your immune system to create specific responses to targets, while many conventional systemic drugs activate the entire immune system in a more generalized manner. Insect cell lines have been frequently used as recombinant protein expression systems.

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Delveinsight

FEBRUARY 10, 2021

LMNA gene causes HGPS due to the production of an abnormal lamin A protein. Cardiovascular diseases, cerebrovascular problems, loss of hearing, hardening of arteries ( atherosclerosis ), cataracts , insulin resistance , and hip dislocation are among the most common complications of progeria.

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XTalks

SEPTEMBER 17, 2020

Acromegaly Surrogate Endpoint: Serum growth hormone and serum insulin-like growth factor 1 (IGF-1) are acceptable surrogate endpoints for acromegaly clinical trials involving somatostatin analogs such as octreotide, lanreotide and pasireotide. Dietary changes, including restriction of salt and animal protein, are also recommended.

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The Pharma Data

NOVEMBER 2, 2020

On average, people started eating fewer calories after a week, and saw their “good” HDL cholesterol increase while their levels of “bad” LDL cholesterol, insulin and triglycerides all fell. Experts called the findings “interesting,” but stressed the work is very preliminary.

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XTalks

AUGUST 2, 2023

Johnson & Johnson’s Top 5 Best-Selling Drugs of 2022: 1) Stelara (ustekinumab) Stelara is an immunosuppressant biologic therapy that blocks the IL-12 and IL-23 proteins that play a role in plaque psoriasis and Crohn’s disease. The monoclonal antibody targets CD20, a protein found on the surface of B lymphocytes (B cells).

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Trialfacts

NOVEMBER 26, 2023

In summary, the main question that we want to answer with this study is: “Does lifting light weights in older men and women while consuming dairy protein, promote glycemic response, muscle gains and improve the ability to get around?” Why Participate? Participants will receive a free consultation with a nutritionist.

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Roots Analysis

MARCH 21, 2022

These devices can be used for controlled delivery of small molecules, as well as large macromolecules ( such as insulin, growth hormones, immunobiological vaccine, receptor agonist, proteins and peptides ). This can be attributed to their relatively more efficient and patient friendly mode of drug delivery.

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The Pharma Data

NOVEMBER 11, 2020

ADDS IN VITRO PHARMACOLOGY AND EXPANDS PROTEIN SCIENCES. She quickly started to collect money for an X-ray apparatus and continued the X-ray analysis of natural products with a research focus on sterols and other biologically interesting molecules, including insulin and penicillin.

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XTalks

APRIL 22, 2022

Flow cytometry is an analytical technique that is used to detect the presence of cell surface markers as well as intracellular proteins using antibodies in individual cells suspended in a buffer solution, which pass through a laser beam one at a time ( Figure 1 ). What is Flow Cytometry? What is a Receptor Occupancy Assay?

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Delveinsight

AUGUST 20, 2020

Generating insulin-producing pancreatic beta cells from stem cells to substitute those damaged by the immune system is a promising approach for diabetes treatment. Amyloid oligomers are clusters of individual amyloid proteins and represent a target that drugs can hit before full-blown amyloid plaques form.

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XTalks

SEPTEMBER 28, 2023

Using rBST results in higher concentrations of insulin-like growth factor 1 (IGF-1), a protein typically present in milk. There’s been varied research regarding the synthetic hormone’s association with breast cancer.

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The Pharma Data

MAY 14, 2021

It may also improve your sensitivity to insulin, which means it works better in your body. Talk to your doctor about whether you need to adjust your meds or insulin dose to keep your levels high enough. You can also get protein from vegetarian things like tofu. Regular physical activity helps you feel better.

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The Pharma Data

DECEMBER 13, 2020

PXL770 is a first-in-class, oral direct adenosine monophosphate-activated protein kinase (AMPK) activator. AMPK activation has the potential to improve the underlying root causes of NASH, such as insulin resistance, the dysregulation of lipid and glucose metabolism and inflammation. . Placebo.

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