XTalks

JANUARY 5, 2021

The test identifies SARS-CoV-2 protein fragments from nasal swab samples. AI is expected to make significant strides in the life science and healthcare sectors in 2021. Reliable and rapid testing will continue to be a need next year as effective tracing and testing will be key to helping resolve the pandemic.

Life Science 98

Life Science Clinical Trials Clinical Trials Trials 98

XTalks

DECEMBER 17, 2021

Xtalks is taking a look at some of the major stories and innovations of the year in the life sciences, many of which were driven by new, emerging and improved technologies. The year 2021 was all about continuing innovations in the life sciences. Life Science Innovations: Malaria and Influenza Vaccines.

Life Science 98

Life Science Vaccination Vaccine Trials 98

Medical Xpress

MARCH 1, 2023

Cholesterol tremendously increases the toxicity of a peptide implicated in Alzheimer's progression, according to research by scientists in the Department of Biochemistry and Biophysics in Texas A&M's College of Agriculture and Life Sciences.

Protein 92

Protein Life Science Scientist Research 92

XTalks

JUNE 23, 2022

Ayesha also discussed the FDA approval of Alnylam’s RNAi therapeutic Amvuttra for the treatment of polyneuropathy associated with a rare protein disorder called hereditary transthyretin-mediated (ATTR) amyloidosis. Amvuttra RNAi Therapeutic Wins FDA Approval for Rare Genetic Protein Disorder.

Life Science 52

Life Science FDA Approval Protein Drugs 52

XTalks

MARCH 31, 2023

By growing high quality crystal structures of protein-based therapeutics under microgravity, researchers can gain better insights into their complex structures and stability. The proteins will be analyzed back on Earth using techniques such as X-ray diffraction and compared with crystals from the same biologics grown on Earth.

Protein 97

Protein Research Development Manufacturing 97

BioPharma Reporter

MARCH 22, 2022

Fujifilm Irvine Scientific, Inc, has announced the acquisition of Shenandoah Biotechnology, a company supplying recombinant proteins to the drug discovery, life science research, and cell and gene therapy markets.

Gene Therapy 98

Gene Therapy Life Science Protein Gene 98

XTalks

FEBRUARY 29, 2024

Dual-function fusion proteins represent a cutting-edge approach in biopharmaceutical research, offering a promising avenue for the development of novel therapeutics in the treatment of complex diseases such as cancer and autoimmune disorders. At the helm of this venture is Dr. Taylor H. How is your lead program differentiated?

Protein 94

Protein Development Clinical Trials Clinical Trials 94

XTalks

MAY 7, 2021

As Novavax awaits emergency use authorization (EUA) from the US Food and Drug Administration (FDA) for its protein-based COVID-19 vaccine NVX-CoV2373, the company shared new data this week on the vaccine’s efficacy against the South African B.1.351 1.351 variant.

Protein 97

Protein Vaccination Vaccine Trials 97

XTalks

NOVEMBER 26, 2024

This progressive disease occurs when misfolded transthyretin (TTR) proteins form amyloid deposits in the heart, leading to cardiac dysfunction. Attruby offers a more potent option , following Pfizer’s tafamidis (Vyndaqel and Vyndamax), the first therapy and TTR stabilizer approved to treat ATTR-CM.

Genetic Disease 105

Genetic Disease Genetics Protein Clinical Development 105

XTalks

DECEMBER 26, 2024

The BROADWAY trial tested obicetrapib, a novel cholesteryl ester transfer protein (CETP) inhibitor, as a monotherapy in adult patients with heterozygous familial hypercholesterolemia (HeFH) or atherosclerotic cardiovascular disease (ASCVD). Unlike CETP inhibitors, PCSK9 inhibitors block a protein that regulates cholesterol levels.

Trials 52

Trials Life Science Clinical Trials Clinical Trials 52

Pharmaceutical Technology

OCTOBER 20, 2022

The funding round saw participation from current investors of the company, Advent Life Sciences and Belinda Termeer. This drug is an allosteric protein translation modulator that acts on eIF4E. According to preclinical research, PIC compounds modulate protein translation but do not hinder the process.

Development 130

Development Drugs Protein Life Science 130

XTalks

JUNE 20, 2022

Hereditary ATTR has an autosomal dominant pattern of inheritance and is caused by point mutations in the transthyretin ( TTR ) gene that codes for the transthyretin transport protein found in the plasma and cerebrospinal fluid.

FDA Approval 98

FDA Approval Protein Genetics RNA 98

pharmaphorum

JULY 26, 2021

The most complete database of protein structures ever assembled, developed with the help of Google’s artificial intelligence unit DeepMind, has been made freely available to researchers around the world. Demis Hassabis. ” The post Google’s DeepMind puts human proteome online for free appeared first on.

Protein 130

Protein Genome Genomics Life Science 130

XTalks

JULY 20, 2022

It is also the first protein-based COVID-19 vaccine to be authorized in the country. Read the full articles here: Novavax Vaccine Becomes First FDA-Authorized Protein Vaccine for COVID-19. Subscribe to the Xtalks Life Science Podcast to never miss a new episode.

Life Science 52

Life Science Vaccination Vaccine Drugs 52

BioSpace

MAY 7, 2024

The newest company by the life sciences venture capital firm, Prologue Medicines will search through the vast viral proteome to identify proteins with therapeutic potential.

Life Science 72

Life Science Protein Medicine 72

XTalks

MAY 29, 2024

During his tenure at Icos, Dr. Lee integrated protein crystallography and structural screening technologies into the company’s research programs and was instrumental in the development of phosphoinositide 3-kinase (PI3K) delta inhibitors, leading to an FDA-approved product.

Life Science 52

Life Science FDA Approval Drugs Development 52

XTalks

JANUARY 19, 2022

The research shows that exercise increases levels of synaptic proteins in the brain involved in maintaining and strengthening neuronal connections. The researchers also found these proteins could be protective even in people with dementia and other neurodegenerative diseases like Alzheimer’s.

Life Science 52

Life Science Protein Development Research 52

Pharmaceutical Technology

MARCH 10, 2023

The opening of this new facility plays into the UK government’s Life Sciences Industrial Strategy. Operations at the CBC will focus on building plasmids , viral vectors and recombinant proteins for the production of cell and gene therapies.

Gene Therapy 264

Gene Therapy Manufacturing Gene Clinical Trials 264

Drug Discovery Today

OCTOBER 7, 2024

Researchers from the Institute of Biotechnology at the Life Sciences Center of Vilnius University – Dalia Smalakyte, Audrone Rukšenaite, Dr Giedrius Sasnauskas, Dr Giedre Tamulaitiene, and Dr Gintautas Tamulaitis – have revealed the structure of the CRISPR-Cas "protein scissors" found in bacteria and provided mechanistic details on how they function. (..)

Protein 45

Protein Bacteria Life Science Research 45

XTalks

JANUARY 7, 2025

Symvess is a one-time, single-use, acellular tissue-engineered vessel (ATEV) composed of human extracellular matrix proteins. Manufactured using vascular smooth muscle cells derived from human aortic tissue, Symvess offers a novel solution for patients with traumatic vascular injuries.

FDA Approval 105

FDA Approval Engineer Clinical Trials Clinical Trials 105

Pharmaceutical Technology

JUNE 4, 2023

There are two main genes in the AAV genome, rep and cap, which encode nine different proteins. Transcription of the rep gene is initiated from the p5 or p19 promoters to, respectively, produce the large (Rep78 and Rep68) and small (Rep52 and Rep40) nonstructural Rep proteins.

Gene 262

Gene Gene Therapy Genetics DNA 262

Scienmag

FEBRUARY 5, 2021

Membrane-localized phage proteins may also help revitalize, enhance existing antibiotics A study from the Center for Phage Technology, part of Texas A&M’s College of Agriculture and Life Sciences and Texas A&M AgriLife Research, shows how the “hidden” genes in bacteriophages — types of viruses that infect and destroy (..)

Gene 74

Gene Bacteria Life Science Development 74

XTalks

JANUARY 21, 2025

By combining a monoclonal antibody against TROP2 a protein frequently overexpressed in cancers with a potent chemotherapy payload, it minimizes damage to healthy cells while attacking tumors effectively. Datroway leverages DXd technology to precisely target cancer cells.

Antibody 105

Antibody FDA Approval HR Trials 105

XTalks

NOVEMBER 8, 2024

Top Hospital-Based Healthcare Innovations Google DeepMind AlphaFold 3: Rendering Molecules in HD Drug discovery often hinges on predicting how proteins interact with each other. Understanding these interactions is like solving a three-dimensional puzzle with thousands of pieces.

Doctor 104

Doctor Doctors Protein Nurses 104

XTalks

MAY 10, 2023

The treatment, an antisense oligonucleotide developed by Biogen, targets abnormal proteins arising from SOD1 mutations, which are associated with the development of ALS in some patients. Subscribe to the Xtalks Life Science Podcast to never miss a new episode.

Life Science 40

Life Science Vaccination Vaccine FDA Approval 40

Pharmaceutical Technology

FEBRUARY 13, 2023

Rather than replacing mutated genes with functional copies, STK-001 promotes protein production in the healthy copy of the SCN1a gene. SK Life Science is a subsidiary of SK, a South Korean holding company. Stoke Therapeutics is working on an antisense oligonucleotide called STK-001.

Research 264

Research Gene Gene Therapy Genome 264

Pharmaceutical Technology

APRIL 18, 2023

Innovation S-curve for the pharmaceutical industry HIV peptides is a key innovation area in pharmaceuticals HIV peptides are fragments derived from HIV envelope gp160 protein, the HIV matrix/capsid proteins, and the HIV gag, pol and env gene products.

Protein 147

Protein Vaccine Vaccination Production 147

pharmaphorum

OCTOBER 4, 2022

The life sciences company Solid Biosciences is merging with the privately-held gene therapy company AavantiBio in a deal which is expected to result in a combined sum of $215 million in cash and investments – projected to be enough for funding into 2025. This is due to close concurrently with the merger.

Gene Therapy 115

Gene Therapy Gene Life Science Genetics 115

XTalks

NOVEMBER 21, 2024

It is characterized by the build-up of abnormal protein deposits in the heart tissue, leading to stiffening of the heart walls and impairing its ability to pump blood effectively. Cardiac amyloidosis, a serious and often underdiagnosed heart condition, poses significant diagnostic challenges even for experienced clinicians.

Production 105

Production Protein Life Science Trials 105

XTalks

OCTOBER 12, 2021

14-3-3 zeta) protein, which the UToledo researchers had been studying for its role in immune-related pathologies, such as aortic aneurysms and in signaling pathways involving the pro-inflammatory cytokine interleukin-17. However, they found the opposite to be true, where the protein was actually protective against development of the disease.

Vaccination 105

Vaccination Vaccine Research Immune Response 105

XTalks

NOVEMBER 6, 2024

Gelteq’s formulations enable the delivery of various active ingredients like branched-chain amino acids, protein, caffeine and essential minerals, opening applications in sports performance, nutrition and therapeutic use.

Drug Delivery 104

Drug Delivery Drugs Bioequivalency Bioavailability 104

XTalks

JANUARY 13, 2022

The study looked at several synaptic proteins in the brain involved in maintaining healthy communication between neurons. The researchers found that older individuals who exercised had higher levels of these proteins. Key Brain Proteins Maintain Cognitive Health.

Protein 98

Protein Research Regulation Life Science 98

Pharmaceutical Technology

MAY 8, 2023

This protein also serves as a target for neutralizing antibodies, which can be used to develop for therapeutic as well as diagnostic applications. There are four types of influenza viruses: A, B, C, and D. Hemagglutinin (HA), an envelope glycoprotein on the influenza virion enables the virus to enter and spread between cells.

Antibody 246

Antibody Vaccine Vaccination Dermatology 246

Medical Xpress

DECEMBER 13, 2024

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, have discovered how a protein called lamin A helps repair the protective barrier around a cell's DNA.

DNA 52

DNA Genetics Life Science Protein 52

XTalks

APRIL 13, 2021

synuclein, a protein involved in the formation of amyloid deposits in the brain characteristic of Parkinson’s disease and other neurodegenerative disorders, is also implicated in melanoma. The scientists found that the amyloid-forming protein is expressed at higher levels in melanoma cells than in normal healthy skin. In addition to ?-synuclein,

Research 98

Research Protein In-Vitro Scientist 98

XTalks

MARCH 11, 2025

Vepdegestrant, an investigational oral therapy, utilizes PROteolysis TArgeting Chimera (PROTAC) technology a mechanism that harnesses the bodys natural protein disposal system to selectively target and degrade the estrogen receptor.

Trials 59

Trials Clinical Trials Clinical Trials Protein 59

XTalks

JULY 28, 2020

According to the team – who published their findings in the journal Science – their research is the first to investigate whether these pervasive, “inactive” compounds have any effects on key molecular targets involved in health.

Protein 103

Protein Drugs In-Vitro Scientist 103