Scienmag

SEPTEMBER 22, 2021

CHAPEL HILL, NC – Mucus is an essential protective layer of gel-like liquid composed largely of proteins called mucins throughout our airways. One of them, called MUC5B, is crucial for the innate defense against the various things we inhale.

Protein 77

Protein Scientist Medicine 77

XTalks

DECEMBER 12, 2023

Plasma medicine is a critical and specialized field within healthcare, centering on the use of human plasma for the development and administration of life-saving treatments. Human plasma, the clear, liquid portion of blood, is composed of water, electrolytes, nutrients and crucial proteins such as antibodies, clotting factors and albumin.

Medicine 111

Medicine Recombinant Antibody Protein Antibody 111

Scienmag

MAY 11, 2021

The researchers have demonstrated that silencing or inhibiting the activity of these proteins completely reverses the aortic disease in a mouse model of Marfan Syndrome Credit: CNIC Scientists at the Centro Nacional de Investigaciones Cardiovasculares Centro de Biología Molecular Severo Ochoa (CBM-CSIC-UAM) have discovered that the nitric oxide (NO) (..)

Protein 96

Protein Scientist Research Cardiology 96

Scienmag

MARCH 29, 2021

Findings from Johns Hopkins Medicine study have potential implications for understanding cancer cell spread Credit: Deborah Andrew and JiHoon Kim, Johns Hopkins Medicine. Working with fruit flies, scientists at Johns Hopkins Medicine say they have identified a new molecular pathway that helps steer moving cells in specific directions.

Scientist 75

Scientist Medicine Protein 75

Scienmag

MARCH 29, 2021

– New research led by scientists at Washington State University has found that a protein known as GBP5 appears to play a key role in suppressing inflammation in rheumatoid arthritis, a potentially debilitating disease in which the immune system mistakenly attacks the […].

Protein 88

Protein Scientist Research Allergies 88

Pharmaceutical Technology

AUGUST 17, 2022

In the last 20 years, this is the biggest buzz in the vaccine market for Lyme disease,” said Yale School of Medicine associate professor Sukanya Narasimhan, PhD, about the Phase III VLA15 trial. However, advances in research allowed for the identification of outer surface protein A (OspA) of the bacteria as a target for vaccines.

Vaccine 299

Vaccine Vaccination Bacteria Protein 299

Scienmag

JULY 6, 2022

Now, a team of scientists from the Salk Institute and Rutgers University have for the first time determined the molecular structure of HIV Pol, a protein that plays […].

Protein 88

Protein Scientist Development Medicine 88

pharmaphorum

SEPTEMBER 14, 2020

Here he gives us a deeper look at how genomic medicine is evolving and the barriers that are preventing it from reaching its full potential. At that time, we thought this would be the holy grail for medicine. Now, however, the field is changing with respect to genomic medicine.

Genomics 119

Genomics Genome Medicine Gene 119

Scienmag

MARCH 1, 2022

March 1, 2022) — A ubiquitous protein called sigma 1 receptor, which is known to protect cells from stress, appears key to the function and survival of the neurons most impacted by glaucoma, scientists report. March 1, 2022) — A ubiquitous protein called sigma 1 receptor, […]. AUGUSTA, Ga.

Protein 77

Protein Scientist Medicine 77

Scienmag

JULY 20, 2021

New research published in the Journal of Leukocyte Biology reveals that certain protein markers may indicate which patients have stable forms of CLL and which have more aggressive types. Identifying these proteins may not only help determine patients’ prognoses but also point […].

Protein 75

Protein Scientist Research Medicine 75

Pharmaceutical Technology

JANUARY 4, 2023

Findings from a study, which was conducted by Transcenta and Shanghai Jiao Tong University scientists on TST003 to treat androgen receptor-negative/low prostate cancer, were published by Nature Cancer in May last year. The Gremlin1 protein was found to promote lineage plasticity while driving castration resistance in prostate cancer.

Antibody 242

Antibody In-Vivo In-Vitro Protein 242

Medical Xpress

NOVEMBER 10, 2022

Scientists have used a proteomics approach to identify a three-protein signature in the blood that can improve detection of isolated impaired glucose tolerance, a form of prediabetes. The research, led by scientists from the Medical Research Council (MRC) Epidemiology Unit at the University of Cambridge, U.K.,

Protein 75

Protein Scientist Medicine Research 75

Medical Xpress

JANUARY 31, 2023

Now, scientists based at the University of California Los Angeles have found that compounds which target the circadian clock and affect the synthesis of collagen—a protein which is important for skin repair—could improve scar healing. It may even require further surgical treatment.

Medicine 98

Medicine Protein Scientist Research 98

Scienmag

JULY 4, 2022

Focusing on that cycle in the hepatitis A virus (HAV), UNC School of Medicine scientists discovered that replication requires specific interactions between the human protein ZCCHC14 and a group of enzymes called TENT4 poly(A) […].

Scientist 71

Scientist Protein Drugs Medicine 71

Scienmag

JUNE 16, 2022

Scientists are starting to understand the precise workings of a type of gene that, unlike other genes, does not code for proteins – the building blocks of life.

Scientist 77

Scientist Gene Development Protein 77

Scienmag

NOVEMBER 11, 2020

Yale researchers have discovered a protein that helps protect hosts from infection with the tick-borne spirochete that causes Lyme Disease, a finding that may help diagnose and treat this infection, they report Nov. 11 in the journal PLOS Pathogens.

Protein 63

Protein Scientist Research Medicine 63

Scienmag

JULY 22, 2021

New UCLA research identifies TAF12 as a potential cancer drug target FINDINGS Scientists from the UCLA Jonsson Comprehensive Cancer Center have identified a key protein, transcription factor TAF12, that plays a critical role in the formation of a preinitiation complex, which consists of over one hundred proteins that are necessary for the transcription (..)

Scientist 75

Scientist Protein Drugs Research 75

Scienmag

AUGUST 31, 2020

A team led by a biomedical scientist at the University of California, Riverside has found a new mechanism responsible for the abnormal development of neuronal connections in the mouse brain that leads to seizures and abnormal social behaviors. UC Riverside mouse study focused on neurons in the hippocampus Credit: Ethell lab, UC Riverside.

Protein 97

Protein Scientist Development Research 97

pharmaphorum

DECEMBER 11, 2024

In a new pharmaphorum podcast, editor-in-chief Jonah Comstock speaks with Dr Victoria Richon, CEO of Entact Bio, a company focused on the small molecule space, with its team of scientists, entrepreneurs, drug creators, and problem solvers working together to bring new medicines to patients who currently have few options.

Medicine 52

Medicine Protein Scientist Drugs 52

Scienmag

APRIL 27, 2022

CHAPEL HILL, NC – Inside embryonic cells, specific proteins control the rate at which genetic information is transcribed from DNA to messenger RNA – a crucial regulatory step before proteins are created. Those specific “regulatory” proteins are called transcription factors, and they do their thing by binding to […].

Scientist 83

Scientist Gene RNA Protein 83

Scienmag

NOVEMBER 17, 2020

Scientists have established a new method to image proteins that could lead to new discoveries in disease through biological tissue and cell analysis and the development of new biomaterials that can be used for the next generation of drug delivery systems and medical devices.

Protein 67

Protein Drug Delivery Systems Drug Delivery Scientist 67

Scienmag

MAY 7, 2021

The disorder, scientists found, is caused […].

Genetics 95

Genetics Genetic Disease RNA Protein 95

Pharma Times

DECEMBER 18, 2023

MCI patients had 25% lower levels of serotonin compared to healthy patients Researchers from Johns Hopkins Medicine have suggested that serotonin loss in parts of the brain may play a role in cognitive decline in the early stages of Alzheimer’s disease (AD). MCI describes the diagnostic stage between normal brain function in ageing and AD.

Medicine 123

Medicine Scientist Protein Research 123

Scienmag

JUNE 29, 2022

In ACS Infectious Diseases, scientists now report that apratoxin S4, an anticancer drug candidate that targets a […]. More than two years into the COVID-19 pandemic, people are realizing that the “new normal” will probably involve learning to co-exist with SARS-CoV-2.

Protein 87

Protein Scientist Drugs Research 87

Scienmag

SEPTEMBER 21, 2020

A druggable pocket in the SARS-CoV-2 Spike protein that could be used to stop the virus from infecting human cells has been discovered by an international team of scientists led by the University of Bristol.

Protein 71

Protein Scientist Research Medicine 71

Scienmag

AUGUST 11, 2020

An international team of scientists, including a researcher from Sechenov University, reviewed scientific articles on proteins (and genes encoding them) that help cancer cells enter the brain.

Scientist 62

Scientist Gene Protein Research 62

Pharmaceutical Technology

JULY 5, 2022

Researchers at the UNC School of Medicine have discovered that hepatitis A virus (HAV) replication needs particular interactions between the human protein ZCCHC14 and TENT4 poly(A) polymerases, a group of enzymes. In addition, the scientists later found that the HAV needs TENT4A/B for its replication.

Protein 130

Protein RNA Genomics Genome 130

Scienmag

OCTOBER 12, 2020

Potential new antibiotics work by disrupting bacterial membrane and summoning immune cells in animal models PHILADELPHIA–A team led by scientists in the Perelman School of Medicine at the University of Pennsylvania has engineered powerful new antimicrobial molecules from toxic proteins found in wasp venom.

Bacteria 40

Bacteria Engineer Scientist Medicine 40

Scienmag

JUNE 8, 2021

New structure shows how virus envelope protein hijacks cell-junction protein and promotes viral spread; findings could speed the design of drugs to block severe effects of COVID-19 Credit: Brookhaven National Laboratory UPTON, NY–Scientists at the U.S.

Protein 98

Protein Scientist Drugs Medicine 98

pharmaphorum

JANUARY 19, 2022

While the specific research goals have been kept a closely guarded secret, some scientists propose that rejuvenating cells in a lab could be a path to prolonging human life. According to Altos Labs, activity will be organised across two branches: the Institute of Science and the Institute of Medicine.

Scientist 130

Scientist Medicine Protein Research 130

Scienmag

APRIL 13, 2022

Cancer cells can disrupt a metabolic pathway that breaks down fats and proteins to boost the levels of a byproduct called methylmalonic acid, thereby driving metastasis, according to research led by scientists at Weill Cornell Medicine.

Protein 84

Protein Scientist Medicine Research 84

Scienmag

DECEMBER 8, 2020

A Georgia Cancer Center scientist wants to help those therapies work better by better understanding the complex DNA damage repair process, because sometimes these therapies can inadvertently […].

Protein 76

Protein DNA Scientist Production 76

Scienmag

JANUARY 11, 2021

Fralin Biomedical Research Institute at VTC scientists say brain protein deficit boosts susceptibility to seizures Credit: Virginia Tech For the brain to learn, retain memories, process sensory information, and coordinate body movements, its groups of nerve cells must generate coordinated electrical signals.

Protein 58

Protein Scientist Research Medicine 58

Scienmag

APRIL 15, 2021

Team of Japanese and European scientists identify a novel genetic mitochondrial disorder by analyzing DNA samples from three distinct families Credit: Fujita Health University DNA ligase proteins, which facilitate the formation of bonds between separate strands of DNA, play critical roles in the replication and maintenance of DNA.

Genetics 105

Genetics DNA Genomics Genome 105

Scienmag

APRIL 15, 2021

Credit: Department of Medicinal Chemistry, TMDU Tokyo, Japan – A team of scientists led by the Institute of Biomaterials and Bioengineering at Tokyo Medical and Dental University (TMDU) have created novel molecules that prevent human immunodeficiency virus (HIV) particles from attacking immune cells.

Protein 79

Protein Scientist Medicine 79

Medical Xpress

NOVEMBER 18, 2022

Northwestern Medicine scientists have discovered the pathways through which autoantibodies—immune proteins that mistakenly attack a person's own body—leak out of blood vessels and cause primary graft dysfunction in some lung transplant recipients, according to findings published in the Journal of Clinical Investigation (JCI).

Protein 75

Protein Scientist Medicine 75

Scienmag

MARCH 18, 2021

— Scientists at the University of Wisconsin-Madison have developed a way to use a cell’s own recycling machinery to destroy disease-causing proteins, a technology that could produce entirely new kinds of drugs. Some cancers, for instance, are associated with abnormal proteins or an excess of normally harmless proteins.

Protein 49

Protein Scientist Development Drugs 49