Roots Analysis

MAY 21, 2024

Proteins are the chains of amino acids linked together in different combinations and perform a wide variety of functions. However, continuous regulation of the cellular proteome is essential for maintaining the right balance of different proteins necessary for normal cellular function, survival, and proliferation.

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pharmaphorum

AUGUST 18, 2020

This is a question that a consortium of European pharma companies hopes to answer as it aims to rapidly develop new therapies to combat the pandemic. The trick is to look for proteins that are used across all coronavirus types and tend not to vary much from one virus species to another. But also included in the 77.7

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Protein Pharma Companies RNA Drugs 121

BioPharma Reporter

JUNE 27, 2024

The new generative AI model released by EvolutionaryScale will be used by researchers and pharma companies to empower drug discovery.

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Protein Pharma Companies Drugs Research 52

Pharmaceutical Technology

FEBRUARY 13, 2023

Rather than replacing mutated genes with functional copies, STK-001 promotes protein production in the healthy copy of the SCN1a gene. In October 2022, mjn-neuro signed a commercialization agreement with the pharma company Neuraxpharm Group to market mjn-SERAS.

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The Pharma Data

DECEMBER 20, 2020

SN14 works by targeting the coronavirus’ nucleocapsid and spike proteins to prevent viral replication using the company’s ImmunoBody DNA vaccine technology. UK drug developer Scancell said it has chosen a COVID-19 vaccine candidate, SN14, from more than a dozen potential products to advance to a clinical trial. .

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pharmaphorum

AUGUST 7, 2020

It is part of a five-point plan by Pfizer launched in March that urged all pharma companies and biotechs to work together with government agencies and academic institutions to tackle the COVID-19 pandemic. Pfizer will provide contract manufacturing services at its facility in McPherson, Kansas, to supply the drug to Gilead.

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BioPharma Reporter

NOVEMBER 6, 2023

The big pharma company Bristol Myers Squibb (BMS) committed up to $180 million for a phase 1-ready antibody-drug conjugate (ADC) for the treatment of blood cancer from the U.S.-South South Korean biotech company Orum Therapeutics.

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Protein Pharma Companies Antibody Drugs 52

pharmaphorum

JANUARY 12, 2023

In this case, the technology will be used to aid computer-aided drug discovery (CADD) – an approach that has been around for decades, but is being transformed by quantum chemistry techniques – and specifically to model the interactions between proteins and their ligands in silico.

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pharmaphorum

FEBRUARY 16, 2021

Inflammasomes are a group of intracellular proteins associated with the inflammatory response, and prior research has linked the NLRP3 inflammasome to the aggregation of amyloid beta and tau protein – which together form the characteristic plaques and tangles in the brains of AD patients.

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Delveinsight

SEPTEMBER 3, 2021

The post Charcot-Marie-Tooth Disease Market Size Expects Growth Owing to Increasing Prevalence, Influx of Pharma Companies and Novel Therapies appeared first on DelveInsight Business Research.

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pharmaphorum

APRIL 21, 2022

One of the leading companies in the bid to bring a new class of alpha-synuclein targeting drugs to market for Parkinson’s disease – AbbVie – is ducking out of the challenge. ” She added that BioArctic will now “investigate options to continue the development of this asset.”

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pharmaphorum

NOVEMBER 23, 2021

Sanofi is the first pharma company to partner with Baidu on its LinearDesign AI platform, which has been developed specifically to optimise the sequence of mRNA-based vaccines and drugs. Specific financial terms have not been disclosed.

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BioPharma Reporter

JULY 31, 2023

Boston-based pharma company Ratio Therapeutics has initiated dosing in a phase 1 study evaluating the pharmacokinetics, biodistribution and radiation dosimetry of a novel fibroblast activation protein-alpha (FAP)-targeted radiopharmaceutical, RTX-1363S, for PET imaging in adult healthy volunteers.

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Pharma Companies Protein Development 52

pharmaphorum

DECEMBER 8, 2020

Its approach involves licensing rights to the antibodies to other pharma companies, rather than bringing its own candidates through development. Bamlanivimab is directed against the spike protein of SARS-CoV-2, designed to block the virus’ attachment and entry into human cells.

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XTalks

AUGUST 17, 2020

protein-based biologics) and vaccine treatments. protein-based biologics) : are those which bind to specific components (i.e. A growing area in the immunotherapy space is the development of biological modulators, which are genetically engineered proteins that target specific components of the immune system.

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pharmaphorum

AUGUST 23, 2021

DNA vaccines work by delivering a genetically-engineered plasmid containing the DNA sequence encoding the desired antigen – in this case the SARS-CoV-2 spike protein – which is then taken up by cells. The company also says that it can update the vaccine very easily to deal with mutations in the virus.

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pharmaphorum

SEPTEMBER 18, 2020

But although it was dubbed a “dangerous game”, some companies came out on top… On 6th April 1999, two companies with similar science-based cultures and a shared vision of the pharmaceutical industry came together to form what’s now considered as one of the top ten pharma companies in the world: AstraZeneca.

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pharmaphorum

JUNE 4, 2021

The Noria/PSMA deal gives the drugmaker a preclinical-stage alpha radionuclide compound based on actinium-225 and a small molecule directed towards prostate-specific membrane antigen (PSMA), a transmembrane protein overexpressed in prostate cancer.

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Antibody Licensing Licensing Protein 81

pharmaphorum

JANUARY 18, 2022

Two Spanish pharma companies are joining forces to identify new oral treatments for immune-inflammatory skin diseases with high unmet medical needs. Researchers at Almirall have identified several proteins whose abnormal function is associated with inflammatory immune skin diseases.

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Dermatology Protein Pharma Companies Research 52

pharmaphorum

DECEMBER 24, 2020

Google’s AI company DeepMind grabbed many headlines in November when it solved the 50-year-‘ protein folding problem ’, but there was less theoretical progress made too with the announcement in Nature Medicine of new standards for clinical trials that involve AI. The FDA took a strategic approach to digital health. About the author.

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pharmaphorum

JANUARY 10, 2022

On the back of the approvals for Pfizer/BioNTech and Moderna, suddenly there is a large amount of interest from big pharma companies to get involved in the mRNA space. This not only allowed Pfizer to establish a COVID-19 vaccine but the company also recently announced that it had begun a study testing an mRNA flu vaccine.

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RNA Vaccination Vaccine Pharma Companies 111

pharmaphorum

DECEMBER 21, 2020

As it’s just a messenger molecule, it does not affect the body’s own genetic code when it is injected as a vaccine – but what it does do is instruct cells to code for copies of a certain protein. In this case that is the “spike” protein seen on the surface of the coronavirus that it uses to invade host cells.

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pharmaphorum

FEBRUARY 9, 2022

While therapeutic cancer vaccines are able to help the body identify particular proteins expressed by cancer cells and then to instigate an immune response. The promise of this approach means that there is now a growing pipeline of potential cancer vaccines emerging from within the portfolios of larger pharma companies and biotechs.

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pharmaphorum

OCTOBER 11, 2022

Asked how he made the shift from working out the structure of proteins and how molecules bind to those proteins, to the founding of pharmaphorum and focusing on the digital space, his answer was clear: communication. One of the things I learned through my early academic years is that I was surrounded by brilliant people.

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pharmaphorum

MARCH 9, 2021

Regeneron and Eli Lilly have already got antibody therapies on the market following emergency approvals by regulators including the FDA but pharma companies are beginning to focus on the threat posed by emerging variants.

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pharmaphorum

FEBRUARY 14, 2022

In figures, this was represented by 71% of late-stage pipeline revenue being the result of the companies partnering to develop an asset. Due to the increase in funding, more biotechs and smaller scale pharma companies are able to progress assets further into clinical trials.

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pharmaphorum

NOVEMBER 6, 2022

Here are a few examples on how companies are using AI in diverse ways to accelerate antibody discovery: 1) Generate Biomedicine : Founded in 2018, it is a flagship pioneering company based in Boston and has raised $420M so far. Data generated in each test cycle is used to update AI/ML models for the next cycle of iteration.

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XTalks

OCTOBER 22, 2020

In this sense, pharmaceutical companies have developed different strategies to produce a wide variety of advanced therapy medicinal products (ATMP) and biological products, such as monoclonal antibodies, recombinant proteins, gene therapy viral vectors, CAR-T cells and oncolytic viruses, in order to deliver new medical needs in our society.

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XTalks

JANUARY 3, 2025

Tryngolza works by targeting a protein in the liver, apoC-III, which regulates triglyceride metabolism. People with FCS often have triglyceride levels higher than 880 mg/dL, compared to a healthy target level of below 150 mg/dL. FCS also severely impacts quality of life, causing chronic fatigue and recurrent stomach pain.

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pharmaphorum

AUGUST 23, 2021

Pfizer is the latest big pharma company to take a position on drugs that target CD47 – a ‘don’t eat me’ signal that protects cancer cells from being attacked by the immune system. The drugmaker has agreed a $2.3 The drugmaker has agreed a $2.3

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Protein Pharma Companies Clinical Trials Clinical Trials 59

The Pharma Data

SEPTEMBER 29, 2020

The collaboration has leveraged Sosei’s StaR technology and Structure-based Drug Design (SBDD) capabilities to design oral small molecules that modulate different G protein-coupled receptor (GPCR) targets across multiple disease areas.

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Clinical Trials Clinical Trials Pharma Companies Trials 52

pharmaphorum

NOVEMBER 23, 2020

The pharma company, known as MSD outside North America, will pay the money up front with OncoImmune shareholders receiving further undisclosed milestone payments if certain sales and regulatory goals are achieved.

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pharmaphorum

AUGUST 9, 2022

The potential of the area has motivated an increasing number of companies to emerge in the space, with a greater number of collaborations occurring between these AI-specialists and big pharma companies. Patient focus.

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Drugs Doctors Doctor Pharma Companies 111

pharmaphorum

OCTOBER 12, 2022

Overall, the aim is to improve the efficiency of drug discovery by identifying genetic variants that contribute to human disease in omics data – a broad category that includes DNA profiles, gene transcripts, and protein expression.

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pharmaphorum

JANUARY 12, 2021

With the backing the company already has, Secor said the plan is to focus on preclinical development without needing to worry about funding for the time being. Quizzed about the possibility of an IPO or buyout from a big pharma company, Secor said the focus is very much on developing the technology.

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pharmaphorum

JANUARY 29, 2021

Since Macrae joined the company just four years ago, Sangamo has more than tripled its staff and raised $1.6 It has also built its own manufacturing site and launched partnerships with six big pharma companies. billion in funding.

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pharmaphorum

OCTOBER 20, 2021

The trial – which will be supported by pharma company Eisai and Ionian University in the US – will see if the test can identify people who have mild cognitive impairment (MCI) due to Alzheimer’s disease.

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