Pharmaceutical Technology

DECEMBER 23, 2022

This alliance is utilising the Axiomer ribonucleic acid (RNA) editing platform of ProQR to address ailments affecting the liver and nervous system. Eli Lilly and Company has expanded a licencing and partnership agreement with ProQR Therapeutics to discover, develop and market new genetic medicines.

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Pharmaceutical Technology

MARCH 28, 2023

There is much interest in the industry around RNA-based therapeutics as their utilisation in indications beyond Covid-19 come into focus. This broadening of its portfolio beyond Covid-19 is concurrent with an increased interest in RNA-based therapeutics in the biotech industry, as early successes are reported in new indications.

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Scienmag

NOVEMBER 13, 2020

In a screening for a functional impact to the neuronal differentiation process, Danish researchers identified a specific circular RNA, circZNF827, which surprisingly “taps the brake” on neurogenesis.

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Scienmag

MARCH 9, 2022

A team led by scientists at the University of Birmingham has come a step closer to uncovering the purpose of a distinctive set of modifications found at the beginning of messenger RNA which have long remained a fundamental mystery in molecular biology. Messenger RNAs (mRNAs) are vital for protein production.

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BioSpace

AUGUST 29, 2021

?Laronde has managed to secure as much as $440 million from a Series B financing round to support as many as 100 Endless RNA (eRNA) products and drug programs over the next decade.

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Pharma Times

OCTOBER 21, 2021

Givlaari uses ‘gene silencing’ RNA interference technology, to target the production of pathogenic compounds in people AHP

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Pharmaceutical Technology

MAY 17, 2023

It will use the precision medicine approach, as well as the deep expertise of Chinook Therapeutics in nephrology and knowledge of Ionis Pharmaceuticals in RNA-targeted therapeutics. They will also have the potential to treat diseases that are caused by too little protein by increasing production, thus restoring the protein to normal levels.

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Scienmag

AUGUST 4, 2020

Led by Boyce Thompson Institute’s Andrew Nelson, four partners will identify RNA modifications and develop resources that may lead to hardier crops Credit: Photo credit: Anna Nelson Dittrich ITHACA, NY, August 4, 2020 — RNA perform a variety of functions in cells, helping with everything from regulating genes to building proteins.

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pharmaphorum

JANUARY 19, 2022

The collaboration aims to “close the gap between single-cell RNA sequencing wet-lab services and single-cell data analysis solutions,” which will allow scientists to study the finest details that can be hard to access. Research Instruments is the main distributor for genomic and life science research products in the region.

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Pharmaceutical Technology

NOVEMBER 10, 2023

The advent of messenger RNA (mRNA) therapeutics has revolutionized modern medicines. New innovations in the mRNA technology continue to simplify drug production and improve its potency– biomanufacturers should take note

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Pharmaceutical Technology

AUGUST 2, 2022

GreenLight’s process from formulation of the drug substance and lipid nanoparticle to bulk drug product can be carried out in this facility. The RNA platform of Samsung Biologics permitted GreenLight to move from mRNA vaccine conceptualisation to the delivery of released clinical trial material in under two years.

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XTalks

DECEMBER 4, 2024

Conventional resveratrol products often face challenges like poor absorption and significant gastrointestinal side effects. CAMP4’s RNA-based therapies focus on genetic diseases like urea cycle disorders, while Rapport’s small molecules aim to address epilepsy, pain and bipolar disorder.

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Pharmaceutical Technology

AUGUST 1, 2022

4/5 strain messenger RNA (mRNA). In June, the company and the European Commission (EC) signed an agreement to amend their previously agreed contractual supply schedules for the former’s Covid-19 vaccine booster product (Spikevax, mRNA-1273) or updated booster vaccine candidate.

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Pharmaceutical Technology

MAY 19, 2023

Myeloid Therapeutics will use the funds to expedite the development of its first-in-class trophoblast cell-surface antigen 2 (TROP2)-FcA mRNA-LNP product, MT-302, into a Phase I/II trial for treating TROP2-expressing tumours. Myeloid CEO Daniel Getts said: “Myeloid continues to make significant progress across all aspects of our business. “We

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BioTech 365

JANUARY 22, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Regulating the ribosomal RNA production line.The enzyme that makes RNA from a DNA template is altered to slow the production of ribosomal RNA (rRNA), the most abundant … Continue reading →

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Pharmaceutical Technology

JULY 15, 2022

Health Canada has granted approval for the usage of Moderna’s messenger RNA (mRNA) Covid-19 vaccine, Spikevax, in a 25µg two-dose regimen for active immunisation to prevent Covid-19 in children aged six months to five years. So far, children aged below five years were not eligible to receive the Covid-19 vaccine in Canada.

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Pharmaceutical Technology

MAY 25, 2023

ElevateBio has raised $401m in a Series D financing round for advancing its technology platforms to expedite the design, production and development of cell and gene therapies. The technology platforms include the Life Edit gene editing platform, an RNA, cell, protein, vector engineering and induced pluripotent stem cells (iPSCs) platform.

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Gene Therapy Gene Gene Editing Development 243

Scienmag

DECEMBER 16, 2020

New research from the Whitehead Institute suggests that the products of transcription — RNA molecules — regulate their own production through a feedback loop Credit: Jon Henninger/Whitehead Institute At any given moment in the human body, in about 30 trillion cells, DNA is being “read” into molecules of messenger RNA, the intermediary (..)

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RNA DNA Regulation Production 52

Medical Xpress

NOVEMBER 8, 2022

Researchers at the University Hospital Bonn (UKB) and the Technical University (TU) Dresden have investigated an underlying mechanism and deciphered the driving force of uncontrolled interferon production through studying the rare autoimmune disease Aicardi-Goutières syndrome.

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RNA Genetics Medicine Production 98

Pharmaceutical Technology

AUGUST 21, 2022

The China National Medical Products Administration (NMPA) has granted clearance for Ascletis Pharma’s Investigational New Drug (IND) application of its drug candidate, ASC10, for Covid-19. An RNA-dependent RNA polymerase (RdRp) inhibitor, ASC10 is an oral double prodrug.

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In-Vivo RNA Clinical Development Drugs 162

Pharmaceutical Technology

APRIL 3, 2023

Polyplus, based in Strasbourg, France, produces key components in the production of viral vectors used in cell and gene therapies. Amidst industry-wide shortages, biotechnology companies are moving to shore up viral vector production – an important component of many therapeutic technologies.

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Gene Therapy Gene DNA Reagent 246

World of DTC Marketing

DECEMBER 29, 2020

First, a novel approach was used that didn’t require traditional vaccine production in cell cultures or eggs. Both the Pfizer and Moderna vaccines copied RNA sequence from the virus genome and found a way to manufacture it at scale with high-level processes and quality control. 1455NO-HEALTH-CORONAVIRUS_VACCINES_PFIZER_O_.

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BioTech 365

FEBRUARY 2, 2022

DNA Script Joins Wellcome Leap R3 Program to Advance RNA Products and Therapies DNA Script Joins Wellcome Leap R3 Program to Advance RNA Products and Therapies Multi-year, multi-million dollar collaboration will develop new tools to rapidly accelerate the development of … Continue reading →

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Pharma Mirror

FEBRUARY 2, 2022

Global contract development and manufacturing organisation (CDMO), Recipharm, has today announced the acquisition of GenIbet, a Portuguese CDMO, specialising in the manufacture of biological clinical trial material and novel modalities such as viral vectors, RNA and microbiome.

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Pharmaceutical Technology

DECEMBER 11, 2022

The first subject was dosed in the trial, which is designed to evaluate the safety, tolerability and immunogenicity of a nucleoside-modified RNA-based combination vaccine approach. In November, the companies announced plans for a Phase I clinical trial of the combined vaccine candidate in healthy adult subjects.

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BioTech 365

JANUARY 4, 2022

Global Pharmaceutical Industry Growth Opportunities 2022: Novel Drug Modalities and RNA Therapeutics Transforming R&D Productivity – ResearchAndMarkets.com Global Pharmaceutical Industry Growth Opportunities 2022: Novel Drug Modalities and RNA Therapeutics Transforming R&D Productivity – ResearchAndMarkets.com DUBLIN–(BUSINESS (..)

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Pharmaceutical Technology

MARCH 28, 2023

The system comprises the Cas9 enzyme and a guide RNA. The company will also be eligible to receive research and development milestones of up to an additional $230m, along with royalties on any future products resulting from the deal.

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The Pharma Data

JANUARY 5, 2021

Durham, North Carolina-based Ribometrix announced a strategic collaboration deal with Genentech , a Roche company, to identify and advance novel RNA-targeted small molecule therapeutics. Targeting RNA is believed to be a way to develop therapeutics for so-called undruggable proteins. The first identifies the 3D RNA motifs.

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pharmaphorum

MARCH 16, 2021

In a review of the documents, the BMJ said they showed concerns over unexpectedly low quantities of intact mRNA in batches of the vaccine developed for commercial production. According to the BMJ EMA scientists ensuring the manufacturing quality of the product found “truncated and modified mRNA species present in the finished product”.

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Regulation Vaccination Vaccine RNA 138

pharmaphorum

JULY 20, 2022

Armed with a $100 million second-round financing, CAMP4 Therapeutics is preparing to start the first clinical trial of a drug targeting regulatory RNA (regRNA) molecules that can be used to fine-tune the expression of genes. ” The post CAMP4 raises $100m to take lead RNA drugs into clinic appeared first on. .

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RNA Genetic Disease Drugs Protein 52

Pharmaceutical Technology

OCTOBER 5, 2022

miRecule and Sanofi have entered a strategic partnership and exclusive licence agreement for the development and commercialisation of an antibody-RNA conjugate (ARC) to treat facioscapulohumeral muscular dystrophy (FSHD). The anti-DUX4 RNA therapy was discovered using the DREAmiR platform of miRecule.

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BioTech 365

AUGUST 22, 2020

CHF 637,87Angebotsende: Mittwoch Sep-16-2020 4:36:52 CESTSofort-Kaufen für nur: CHF 637,87Sofort-Kaufen | Zur Liste der beobachteten Artikel hinzufügen Biotech365 : Qiagen QIAxcel for DNA Fragment & RNA Analysis BioMarketplace You want to propose your products or a Biotech Company, a Biotech … Continue reading →

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RNA DNA Production 45

Pharmaceutical Technology

NOVEMBER 10, 2022

According to the deal, Royalty Pharma will acquire Arrowhead’s complete royalty interest in olpasiran, which amounts to a royalty of up to the low double digits on global net product sales. . In November last year, Arrowhead and GlaxoSmithKline (GSK) entered an exclusive licence agreement for experimental RNA interference therapeutic ARO-HSD.

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Pharmaceutical Technology

JUNE 30, 2022

The vaccine leverages self-amplifying RNA (saRNA), which can replicate itself after administration and could be effective at very low doses. This technology can stimulate an immune response with a dose up to 20 times lower than current vaccines, which enhances safety, lowers costs, and increases production speed. .

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BioTech 365

DECEMBER 10, 2021

Global CRISPR Technology Market Research Report 2021: Focus on Design Tools, Plasmid and Vector, Cas9 and G-RNA, & Delivery System Products – ResearchAndMarkets.com Global CRISPR Technology Market Research Report 2021: Focus on Design Tools, Plasmid and Vector, Cas9 and G-RNA, … Continue reading →

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Pharmaceutical Technology

JANUARY 12, 2023

The collaboration will use the vector biology, manufacturing capabilities and the drug development experience of Solid Biosciences and Phlox Therapeutics’ knowledge in genetic cardiomyopathies and RNA therapies. Solid Biosciences stated that the partnership boosts its scientific capabilities along with commercial potential in cardiac therapy.

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RNA Gene Therapy Genetics Genetic Disease 130

Medical Xpress

FEBRUARY 9, 2023

When cells copy DNA to produce RNA transcripts, they include only some chunks of genetic material known as exons and throw out the rest. The resulting product is a fully-mature RNA molecule, which can be used as a template to build a protein.

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