Protein - Clinical Research Informer

At EpiBiologics, a pair of Genentech alumni wants to make next-gen protein degraders

Bio Pharma Dive

MARCH 22, 2023

Armed with a $50 million Series A round, the startup is building off of research from a lab run by protein engineering pioneer Jim Wells.

Protein

Protein Engineer Research

Lilly puts more money into protein degradation

Bio Pharma Dive

AUGUST 25, 2021

The pharma has struck its second research pact focused on drugs that break down harmful proteins in as many years, this time with California biotech Lycia Therapeutics.

Protein

Protein Drugs Research

ALS drugmakers, encouraged by recent FDA feedback, set their sights on a key protein

Bio Pharma Dive

MARCH 27, 2023

A closely watched meeting showed the FDA’s own external advisers think that effects on this protein, known as neurofilament, could be enough to warrant conditional approval of certain drugs.

Protein

Protein Drugs

Gladstone and UCSF scientists discover BET protein role in Covid-19

Pharmaceutical Technology

JULY 20, 2022

Researchers at Gladstone Institutes and UC San Francisco (UCSF) have discovered in a study that bromodomain and extraterminal (BET) proteins are vital for the body to fight Covid-19 infection. . The research also found that BET proteins play two distinct roles in affecting how the SARS-CoV-2 virus interacts with human cells. .

Protein

Protein Scientist Gene DNA

Touting a new way to drug an all-important family of proteins, a startup launches with $100M

Bio Pharma Dive

JANUARY 27, 2022

Backed by some of biotech's most powerful investors, Septerna is looking to usher in the next chapter of medicines that act on G protein-coupled receptors.

Protein

Protein Medicine Drugs

Feinstein Institutes researchers discover new protein for sepsis treatment

Pharmaceutical Technology

FEBRUARY 6, 2023

Researchers at the Feinstein Institutes for Medical Research have discovered a new protein that can be a potential therapeutic target for lethal sepsis. Led by Feinstein Institutes researcher Haichao Wang, the new study focuses on detecting protein mediators that might contribute to uncontrolled immune responses to lethal infections.

Protein

Protein Research Antibody Immune Response

This Protein May Protect Against Alzheimer’s, Scientists Say

AuroBlog - Aurous Healthcare Clinical Trials blog

OCTOBER 16, 2023

In the search for a treatment for Alzheimer’s disease, researchers have zeroed in on a protein with protective effects. A new study reveals how cholesterol and inflammation in different types of human brain cells interact with a protein called ABCA7, which regulates how molecules pass through cell membranes.

Protein

Protein Scientist Regulation Research

AbbVie, targeting a well-known protein family, expands a partnership into neuroscience

Bio Pharma Dive

AUGUST 2, 2022

It’s the second deal in as many years between AbbVie and Sosei Heptares, which together have been trying to develop drugs that target so-called G protein-coupled receptors.

Protein

Protein Development Drugs

Hunting Host Cell Proteins (HCPs) with mass spectrometry

Bio Pharma Dive

JULY 24, 2023

Regulators are recognizing mass spectrometry as a powerful tool in Host Cell Protein analysis. Are you ready to implement HCP-MS?

Protein

Protein Regulation

Blocking a Single Protein Could Prevent Nerve Damage Responsible For Alzheimer’s

AuroBlog - Aurous Healthcare Clinical Trials blog

MARCH 10, 2024

Scientists have identified a key protein in the development of Alzheimer’s disease which could prove critical in slowing or even halting the condition’s progress.

Protein

Protein Scientist Research Development

This Protein Could Help Us Unravel The Mystery of Alzheimer’s

AuroBlog - Aurous Healthcare Clinical Trials blog

MAY 28, 2024

The new research centers on the protein contactin-4 (CNTN4) – thought to play a role in neuronal network […] There are a lot of connected, moving biological parts in our brains, which makes the study of brain diseases particularly challenging.

Protein

Protein Research Clinical Trials Clinical Trials

Novartis-linked startup launches with technology designed to remove ‘destroy’ tags on helpful proteins

Bio Pharma Dive

JULY 28, 2022

Vicinitas and its protein-stabilizing research have attracted $65 million from a group of investors that includes a16z, Deerfield and GV.

Protein

Protein Research

A Common Sleeping Pill May Reduce Buildup of Alzheimer’s Proteins, Study Finds

AuroBlog - Aurous Healthcare Clinical Trials blog

SEPTEMBER 8, 2024

In a study published in 2023, scientists found that using sleeping pills to get some shut-eye could reduce the build-up of toxic clumps of proteins […]

Protein

Protein Scientist Research Clinical Trials

Flashing Lights And a Clicking Sound Cleared Toxic Proteins in Alzheimer’s Mice

AuroBlog - Aurous Healthcare Clinical Trials blog

MARCH 7, 2024

Scientists have now demonstrated how stimulating high-frequency brain waves in mice can clear out the amyloid protein clumps associated with Alzheimer’s. Could Alzheimer’s disease one day be treated by flashes of light and clicks of sound?

Protein

Protein Scientist Research Clinical Trials

With $81M, Entact Bio takes a new approach to fixing helpful proteins

Bio Pharma Dive

DECEMBER 6, 2022

Entact Bio aims to develop medicines that can enhance helpful proteins, rather than block harmful ones, a twist on the usual drugmaking playbook.

Protein

Protein Medicine Development

For The First Time, Scientists Capture The Protein-Lipid Dance on Video

AuroBlog - Aurous Healthcare Clinical Trials blog

APRIL 28, 2024

Our bodies are alive with activity and packed with proteins jammed into fatty membranes or floating in and out of watery cells. Scientists have now, for the first time, captured the dance between the two: a liquid tango featuring proteins and fats as they would normally move in cells.

Protein

Protein Scientist Clinical Trials Clinical Trials

GPCR-targeting drugs: A renewed focus on a ubiquitous group of proteins

Bio Pharma Dive

MARCH 7, 2023

As many as a third of FDA-approved drugs target GPCRs in some fashion, with uses ranging from treating cancer to pain. But biotech startups say there is still room to develop more.

Protein

Protein FDA Approval Drugs Development

A new biotech, built around protein design, springs from David Baker’s lab

Bio Pharma Dive

OCTOBER 30, 2024

Archon Biosciences, co-founded by the winner of the 2024 Nobel Prize in Chemistry, emerged from stealth Wednesday with $20 million in seed capital.

Protein

CDC backs Novavax's protein-based vaccine for COVID-19

Bio Pharma Dive

JULY 20, 2022

Health officials argue a new type of shot could help to persuade unvaccinated people, although some surveys suggest that might not be the case.

Protein

Protein Vaccination Vaccine

Astellas delves deeper into protein degrading drugs with Cullgen deal

Bio Pharma Dive

JUNE 14, 2023

The alliance is Astellas’ second recent partnership involving protein degraders, an emerging area of drug research the company has made a focus in recent years.

Protein

Protein Drugs Research

Initial launches with $75M and a new idea for targeting problematic proteins

Bio Pharma Dive

MAY 1, 2023

The company was co-founded by, among others, Jamie Cate, husband of CRISPR pioneer Jennifer Doudna, and Kevan Shokat, a chemical biologist whose previous work helped lead to KRAS-targeting cancer drugs.

Protein

Protein Drugs

Putative Fidgetin Like Protein 2 drugs in development, 2024

Pharmaceutical Technology

AUGUST 29, 2024

The Putative Fidgetin Like Protein 2 pipeline drugs market research report outlays comprehensive information on the Putative Fidgetin Like Protein…

Protein

Protein Drugs Development Marketing

Myotonin Protein Kinase drugs in development, 2024

Pharmaceutical Technology

AUGUST 29, 2024

GlobalData’s report assesses the drugs in the Myotonin Protein Kinase pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline.

Protein

Protein Development Drugs

Transmembrane Protein PVRIG drugs in development, 2024

Pharmaceutical Technology

AUGUST 29, 2024

GlobalData’s report assesses the drugs in the Transmembrane Protein PVRIG pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline.

Protein

Protein Development Drugs

Generate:Biomedicines and Novartis link on protein therapeutics development

Pharmaceutical Technology

SEPTEMBER 25, 2024

Generate:Biomedicines and Novartis have partnered for the discovery and development of protein therapeutics in multiple disease areas.

Protein

Protein Development

Outrun Therapeutics announces launch with $10m seed funding

Pharmaceutical Technology

APRIL 18, 2024

Outrun Therapeutics announced its launch with $10m seed funding to advance a protein stabilisation pipeline focused on E3 ligase inhibitors.

Protein

Huadong Medicine gets grant for multi-domain active protein for treating metabolic diseases

Pharmaceutical Technology

APRIL 18, 2024

Discover the groundbreaking multi-domain active protein patented by Huadong Medicine Co Ltd for treating metabolic diseases. With increased efficacy and simplified preparation process, this protein is set to revolutionize existing treatments.

Protein

Protein Medicine

Teva puts rival to Prometheus, Pfizer drugs at center of turnaround plans

Bio Pharma Dive

MAY 18, 2023

At an investor day, executives highlighted an experimental inflammatory disease drug targeting the protein TL1A as important to their long-term growth prospects.

Drugs

Drugs Protein

Relay's targeted cancer drug could be safer than its competitors. Is it more effective?

Bio Pharma Dive

OCTOBER 8, 2021

Initial study results for Relay's experimental treatment offer some support for the biotech's protein motion technology, but raise some questions, too.

Protein

Protein Drugs

Protein and peptide synthesis and manufacturing solutions for the pharmaceutical industry

Pharmaceutical Technology

MARCH 28, 2024

Pharmaceutical Technology has listed the leading protein and peptide synthesis solutions and suppliers. Download for free here.

Protein

Protein Manufacturing

E3 Ubiquitin Protein Ligase CBL B drugs in development, 2024

Pharmaceutical Technology

AUGUST 29, 2024

GlobalData’s report assesses the drugs in the E3 Ubiquitin Protein Ligase CBL B pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline.

Protein

Protein Development Drugs

Arvinas gets grant for bifunctional compounds for modulating Tau protein

Pharmaceutical Technology

APRIL 22, 2024

Discover Arvinas Inc's groundbreaking patent for compounds targeting tau protein degradation, offering hope for Alzheimer's and other neurodegenerative diseases. Learn about the promising results and potential therapeutic value of this innovative treatment.

Protein

Roche licenses Sangamo’s technology for another shot at Alzheimer’s drugs

Bio Pharma Dive

AUGUST 6, 2024

Through a new deal, Roche has exclusive rights to Sangamo molecules designed to repress the gene that makes “tau,” a protein many scientists view as a main driver of Alzheimer’s.

Licensing

Licensing Licensing Protein Gene

J&J-backed startup launches with $100M to build better brain drugs

Bio Pharma Dive

MARCH 7, 2023

Rapport Therapeutics aims to find new so-called receptor-associated proteins that could serve as targets for neurological disease medicines. Its most advanced drug is already in early-stage human testing.

Drugs

Drugs Protein Medicine

Pfizer stocks cancer drug pipeline with $2.3B deal for Trillium

Bio Pharma Dive

AUGUST 23, 2021

The acquisition reflects growing industry interest in the cancer-linked protein targeted by Trillium's drugs, most notably shown by Gilead's acquisition of Forty Seven last year.

Drugs

Drugs Protein

Yield10 Bioscience gets grant for genetically engineered oilseed plant expressing plant protein

Pharmaceutical Technology

MARCH 29, 2024

Discover the groundbreaking patent by Yield10 Bioscience Inc for a genetically engineered oilseed plant expressing a plant protein, revolutionizing biotechnology in agriculture.

Genetic Engineering

Genetic Engineering Engineer Genetics Protein

Biogen, Ionis shelve ALS drug following study failure

Bio Pharma Dive

MAY 16, 2024

While results indicated the drug works as intended, it didn’t have enough of an effect on a protein that’s become integral to many ALS research programs.

Drugs

Drugs Protein Research

Innovent Biologics files patent for patent filed for novel heterodimeric fc scaffold proteins

Pharmaceutical Technology

MARCH 26, 2024

Discover Innovent Biologics' groundbreaking patent for novel proteins with heterodimeric antibody Fc, revolutionizing antibody engineering and drug development.

Protein

Protein Engineer Antibody Development

Bromodomain Containing Protein 4 drugs in development, 2023

Pharmaceutical Technology

NOVEMBER 29, 2023

GlobalData’s report assesses the drugs in the Bromodomain Containing Protein 4 pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline.

Containment

Containment Protein Development Drugs

With new startup, immunotherapy pioneer Lieping Chen tries to turn ‘cold’ tumors ‘hot’

Bio Pharma Dive

OCTOBER 25, 2022

Chen, who discovered the cancer-protecting protein PD-L1, will work closely with startup Normunity to find targets that can help the immune system reach ‘cold’ tumors.

Protein

Arcturus Therapeutics files patent for modified human otc protein for treating OTC deficiency

Pharmaceutical Technology

MARCH 26, 2024

Discover how Arcturus Therapeutics' patent for a modified human OTC protein revolutionizes OTC deficiency treatment with codon optimized mRNA sequences.

Protein

FDA lifts hold on PTC Huntington’s disease trial

Bio Pharma Dive

JUNE 20, 2024

The agency has lifted a partial trial suspension based on one-year data showing PTC’s pill suppressed a key protein associated with the disorder.

Trials

Trials Protein

Bristol Myers pays Agenus $200M for drug aimed at top immunotherapy target

Bio Pharma Dive

MAY 18, 2021

The pharma acquired rights to an experimental antibody medicine that blocks a protein, called TIGIT, that's become a focus for several cancer drugmakers.

Protein

Protein Antibody Medicine Drugs

WHO grants emergency use listing to SK bioscience’s SKYCovione

Pharmaceutical Technology

JUNE 20, 2023

Developed using pharmaceutical company GSK’s pandemic adjuvant, the vaccine targets the receptor-binding domain of the SARS-CoV-2 spike protein. The vaccine is based on recombinant protein vaccine technology and is suitable for storage between 2°C and 8°C.

Vaccination

Vaccination Vaccine Protein Clinical Trials

At EpiBiologics, a pair of Genentech alumni wants to make next-gen protein degraders

Lilly puts more money into protein degradation

Trending Sources

ALS drugmakers, encouraged by recent FDA feedback, set their sights on a key protein

Gladstone and UCSF scientists discover BET protein role in Covid-19

Touting a new way to drug an all-important family of proteins, a startup launches with $100M

Feinstein Institutes researchers discover new protein for sepsis treatment

This Protein May Protect Against Alzheimer’s, Scientists Say

AbbVie, targeting a well-known protein family, expands a partnership into neuroscience

Hunting Host Cell Proteins (HCPs) with mass spectrometry

Blocking a Single Protein Could Prevent Nerve Damage Responsible For Alzheimer’s

This Protein Could Help Us Unravel The Mystery of Alzheimer’s

Novartis-linked startup launches with technology designed to remove ‘destroy’ tags on helpful proteins

A Common Sleeping Pill May Reduce Buildup of Alzheimer’s Proteins, Study Finds

Flashing Lights And a Clicking Sound Cleared Toxic Proteins in Alzheimer’s Mice

With $81M, Entact Bio takes a new approach to fixing helpful proteins

For The First Time, Scientists Capture The Protein-Lipid Dance on Video

GPCR-targeting drugs: A renewed focus on a ubiquitous group of proteins

A new biotech, built around protein design, springs from David Baker’s lab

CDC backs Novavax's protein-based vaccine for COVID-19

Astellas delves deeper into protein degrading drugs with Cullgen deal

Initial launches with $75M and a new idea for targeting problematic proteins

Putative Fidgetin Like Protein 2 drugs in development, 2024

Myotonin Protein Kinase drugs in development, 2024

Transmembrane Protein PVRIG drugs in development, 2024

Generate:Biomedicines and Novartis link on protein therapeutics development

Outrun Therapeutics announces launch with $10m seed funding

Huadong Medicine gets grant for multi-domain active protein for treating metabolic diseases

Teva puts rival to Prometheus, Pfizer drugs at center of turnaround plans

Relay's targeted cancer drug could be safer than its competitors. Is it more effective?

Protein and peptide synthesis and manufacturing solutions for the pharmaceutical industry

E3 Ubiquitin Protein Ligase CBL B drugs in development, 2024

Arvinas gets grant for bifunctional compounds for modulating Tau protein

Roche licenses Sangamo’s technology for another shot at Alzheimer’s drugs

J&J-backed startup launches with $100M to build better brain drugs

Pfizer stocks cancer drug pipeline with $2.3B deal for Trillium

Yield10 Bioscience gets grant for genetically engineered oilseed plant expressing plant protein

Biogen, Ionis shelve ALS drug following study failure

Innovent Biologics files patent for patent filed for novel heterodimeric fc scaffold proteins

Bromodomain Containing Protein 4 drugs in development, 2023

With new startup, immunotherapy pioneer Lieping Chen tries to turn ‘cold’ tumors ‘hot’

Arcturus Therapeutics files patent for modified human otc protein for treating OTC deficiency

FDA lifts hold on PTC Huntington’s disease trial

Bristol Myers pays Agenus $200M for drug aimed at top immunotherapy target

WHO grants emergency use listing to SK bioscience’s SKYCovione

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