Hunting Host Cell Proteins (HCPs) with mass spectrometry
Bio Pharma Dive
JULY 24, 2023
Regulators are recognizing mass spectrometry as a powerful tool in Host Cell Protein analysis. Are you ready to implement HCP-MS?
This Protein May Protect Against Alzheimer’s, Scientists Say
AuroBlog - Aurous Healthcare Clinical Trials blog
OCTOBER 16, 2023
In the search for a treatment for Alzheimer’s disease, researchers have zeroed in on a protein with protective effects. A new study reveals how cholesterol and inflammation in different types of human brain cells interact with a protein called ABCA7, which regulates how molecules pass through cell membranes.
Protein 
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Third Rock launches biotech targeting 'notoriously difficult' DNA regulators
Bio Pharma Dive
MAY 13, 2021
With $82 million in hand, Flare Therapeutics is looking to create precision cancer drugs by going after a type of protein called transcription factors.
DNA 240
240 
FDA, in another test of its flexibility, agrees to review Biogen's closely watched ALS drug
Bio Pharma Dive
JULY 26, 2022
But an apparent effect on a protein of interest in ALS research has Biogen convinced the treatment will pass muster with regulators. Known as tofersen, the drug failed in the main study being used to support its approval.
Drugs 321
321 
WHO grants emergency use listing to SK bioscience’s SKYCovione
Pharmaceutical Technology
JUNE 20, 2023
SKYCovione is a self-assembled nanoparticle vaccine and the 12th Covid-19 vaccine to receive a EUL from the regulator. Developed using pharmaceutical company GSK’s pandemic adjuvant, the vaccine targets the receptor-binding domain of the SARS-CoV-2 spike protein.
Vaccine 363
363 
Alyftrek: Vertex Expands Cystic Fibrosis Treatment with Triple-Action Combo
XTalks
JANUARY 6, 2025
The US Food and Drug Administration (FDA) has approved Alyftrek (vanzacaftor/tezacaftor/deutivacaftor), a next-in-class triple combination cystic fibrosis transmembrane conductance regulator (CFTR) modulator, to treat cystic fibrosis (CF) in patients aged six years and older with at least one F508del mutation or another responsive CFTR mutation.
Gene Therapy 105
105 
Mouse Study Reveals Unlikely Connection Between Menthol And Alzheimer’s
AuroBlog - Aurous Healthcare Clinical Trials blog
MAY 18, 2023
In particular, researchers noticed a reduction in the interleukin-1-beta (IL-1β) protein, which helps to regulate the body’s […] It seems the chemical compound can stop some of the damage done to the brain that’s usually associated with the disease.
Protein 246
246 
Study unveils mechanism regulating the transmission of a protein associated with the progression of Parkinson's disease
Medical Xpress
MARCH 2, 2023
Proteins, long polymers comprised of smaller constituents known as amino acids, play a crucial role in the functioning of the human body.
Protein 104
104 
Key Parkinson’s protein could offer new potential targets for treatment
Pharma Times
DECEMBER 20, 2023
Researchers from Johns Hopkins University School of Medicine have revealed new findings about a key pathological protein associated with Parkinson’s disease (PD), which could lead to new treatments. Estimated to affect over 8.5 However, its relation to dopaminergic neuron death is unclear.
Protein 120
120 
The deubiquitylase USP7 found to be a novel cyclin F-interacting protein that regulates cyclin F protein stability
Medical Xpress
NOVEMBER 22, 2022
A new research paper has been published in Aging entitled "The deubiquitylase USP7 is a novel cyclin F-interacting protein and regulates cyclin F protein stability.".
Protein 73
73 
Decoding protein assembly dynamics with artificial protein needles
Scienmag
JANUARY 6, 2022
Protein assembly is essential for the formation of ordered biological structures, but imagine engineering one! This is exactly what researchers at Tokyo Tech have now accomplished with protein needles.
Protein 79
79 
Study finds the metabolic regulator MYC is defective in obesity
Medical Xpress
APRIL 27, 2023
Research led by Maynooth University and published today in the journal Science Signaling has found that the protein MYC is essential for MAIT cell growth, proliferation, metabolism and function. The latest findings are of critical importance to the study of MAIT cells and the development of metabolic disease such as obesity.
Regulation 128
128 
European regulators begin rolling review of AZ’s COVID-19 vaccine
pharmaphorum
OCTOBER 2, 2020
European regulators have started a first ‘rolling review’ of a COVID-19 vaccine, which is being developed by AstraZeneca in collaboration with the University of Oxford. After vaccination, the surface spike protein is produced, priming the immune system to attack the SARS-CoV-2 virus if it later infects the body.
Regulation 105
105 
How can a protein help us remember?
Scienmag
DECEMBER 11, 2021
Studying fruit flies, they found that the Apterous (Ap) protein plays a crucial double role in retaining memories. Not only did it bind with the Chi cofactor to help maintain memories, but it also acted independently to regulate […].
Protein 88
88 
Plotting the placental protein NRK: Understanding the molecular evolution processes underlying placenta acquisition in eutherian ancestors
Scienmag
MARCH 1, 2022
The molecular evolution of placental protein NRK and its function in regulating placental growth has finally been clarified by researchers from Tokyo Tech. They elucidated that eutherian NRK regulates placental development by a novel mechanism, modulating the CK2-PTEN-AKT pathway.
Protein 94
94 
Researchers identify key protein for production of new neurons for memory and learning in adult brain
Medical Xpress
APRIL 21, 2023
A new publication released today in The EMBO Journal identified a key protein in the molecular mechanism triggering neurogenesis in the hippocampus. They found that tight regulation of Yap1 activity is essential as dysregulation can cause tissue disruption seen in the early stages of brain cancer.
Protein 102
102 
How genetics shape blood proteins during development from childhood to adolescence
Medical Xpress
FEBRUARY 21, 2025
Blood proteins serve as crucial indicators of health and disease risk throughout development.
Protein 81
81 
Circular RNA regulates neuronal differentiation by scaffolding an inhibitory transcription complex
Scienmag
NOVEMBER 13, 2020
The results provide an interesting example of co-evolution of a circRNA, and its host-encoded protein product, that regulate each other’s […].
RNA 93
93 
Intracellular temperature sensors: Protein complex exhibits temperature-sensitive activity
Scienmag
NOVEMBER 9, 2021
Osaka, Japan – One degree (Celsius) can make a difference: a team of investigators led by Osaka University has demonstrated regulation of a critical protein complex that occurs only at physiological temperature. Credit: Hiroaki Kubota et al.
Protein 83
83 
RNA editing protein ADAR1 protects telomeres and supports proliferation in cancer cells
Scienmag
MARCH 12, 2021
Credit: The Wistar Institute PHILADELPHIA — (March 12, 2021) — Scientists at The Wistar Institute identified a new function of ADAR1, a protein responsible for RNA editing, discovering that the ADAR1p110 isoform regulates genome […].
RNA 92
92 
Why Plant-Based Meat Safety Differs From That of Animal Protein
XTalks
JULY 26, 2021
But several researchers and experts have brought to light some food safety concerns of plant-based meat, and why it must be treated differently than that of animal protein. Because of their near-neutral pH and high protein and moisture content, plant-based meats are susceptible to microbial growth. FDA Regulation.
Protein 98
98 
Sionna Therapeutics’ IPO: A strategic shift in the cystic fibrosis market
Pharmaceutical Technology
FEBRUARY 25, 2025
Sionna Therapeutics recently secured an initial public offering (IPO) of $191m on the Nasdaq stock exchange, signalling strong investor confidence in its cystic fibrosis (CF) pipeline, particularly its lead candidates, SION-719 and SION-451, which work by stabilising the nucleotidebinding domain 1 domain of the CF transmembrane conductance regulator (..)
Marketing 147
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Untangling the Body’s Smart Sensors: What RNA Binding Proteins Can Tell Us About Gene Regulation
BioSpace
SEPTEMBER 11, 2020
Can you imagine organizing more than 10 terabytes of data into a useful network of information, like creating Google maps from scratch? I certainly can’t, but Eclipse BioInnovations, a San Diego-based biotech start-up, is aiming to do just that for RNA therapeutics.
RNA 98
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New tau regulators and therapeutic targets for neurodegenerative disorders discovered
Medical Xpress
JANUARY 6, 2023
Tauopathies such as Alzheimer's disease are a class of neurodegenerative disorders involving an accumulation of tau proteins, which eventually results in massive loss of brain cells. There is little consensus about the underlying causes and no effective treatments are available currently for these disorders.
Regulation 104
104 
Yale researchers have uncovered a regulator of body weight that could lead to new treatments for metabolic disorders
Scienmag
APRIL 11, 2022
Yale scientists uncover key regulator of body weight. Yale scientists have discovered that a protein known as augmentor-alpha regulates body weight in mice, an insight that could lead to new treatments for metabolic disorders. New Haven, Conn.
Regulation 78
78 
Study reveals protein sirtuin 7 suppresses heat production in brown adipose tissue
Medical Xpress
JANUARY 20, 2023
This process is regulated by a family of signaling proteins called sirtuins. A recent study by researchers from Kumamoto University reveals the mechanism through which the protein sirtuin 7 suppresses thermogenesis in mice. Mammals convert the energy stored in adipose (fat) tissue into heat via a process known as thermogenesis.
Protein 75
75 
New research data on the regulation of hormone-dependent breast cancer
Scienmag
APRIL 22, 2021
Notch proteins are key regulators of growth and differentiation of both normal and cancer cells. Researchers in Turku, Finland, have now demonstrated that the activities of distinct Notch family members are modified differently by phosphorylation.
Hormones 75
75 
Alcohol consumption is affected by a protein linked to the circadian rhythm, new Concordia research finds
Scienmag
JANUARY 11, 2022
A group of researchers has found that at least some of it has to do with a particular protein in the part of the forebrain that regulates, among other things, decision-making and reward perception. It’s a commonly heard question after New Year’s: “Why do we drink the way we do?” Credit: Shimon Amir It’s a […].
Protein 79
79 
Iron found to be an important regulator of neurodifferentiation
Medical Xpress
APRIL 24, 2023
Iron is important for life, and iron deficiency impairs development, but whether the iron level regulates neural differentiation remains elusive. Iron-regulatory proteins (IRPs), including IRP1 and IRP2, are the major regulators of cellular iron homeostasis.
Regulation 66
66 
Protein appears to prevent tumor cells from spreading via blood vessels
Scienmag
JULY 11, 2021
Johns Hopkins researchers describe protein regulating key step in cancer metastasis Credit: Johns Hopkins University Researchers have identified a specialized protein that appears to help prevent tumor cells from entering the bloodstream and spreading to other parts of the body.
Protein 69
69 
Finding the principle regulating the secretion of neurotransmitters, an important clue to brain disease treatment
Medical Xpress
DECEMBER 14, 2022
Professor Suh Byung-chang's research team of the Department of Brain Sciences, DGIST, announced on Wednesday, November 23 that they have identified the molecular mechanism for the activation of "voltage-dependent calcium channels," an important protein that regulates the secretion of neurotransmitters at nerve cell terminals.
Regulation 75
75 
FDA accepts AstraZeneca’s NDA for breast cancer combination therapy
Pharmaceutical Technology
JUNE 13, 2023
Capivasertib is an investigational oral therapy and a potent adenosine triphosphate (ATP)-competitive inhibitor of all three AKT [protein kinase B] isoforms (AKT1/2/3). The regulator will announce its decision during the fourth quarter of 2023. AstraZeneca stated that its NDA is being reviewed under Project Orbis.
HR 245
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Polyphenols may be missing component in regulating inflammatory immune responses
Medical Xpress
FEBRUARY 21, 2023
PCB2DG, a polyphenol with anti-inflammatory properties, works by targeting and directly interacting with the major glutamine transporter protein, alanine serine cysteine transporter 2 (ASCT2), to inhibit the uptake of glutamine, an important amino acid found in the blood.
Kite and Daiichi Sankyo update cell therapy licensing agreement
Pharmaceutical Technology
DECEMBER 8, 2022
Regulators in Japan have granted approval for the manufacturing plant of Kite in El Segundo, California, US, to produce Yescarta for the Japanese market. Directed against a cell membrane protein called CD19, Yescarta uses the immune system of the patient to destroy cancer.
Licensing 305
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Protein Precision: “Harnessing Targeted Protein Degradation”
Roots Analysis
MAY 21, 2024
Proteins are the chains of amino acids linked together in different combinations and perform a wide variety of functions. These are the vital structural component of cells, which help in cell functioning and regulation of building body tissues.
Protein 40
40 
Hemp Beverages: How this Growing Market Navigates US Regulations
XTalks
JUNE 3, 2024
Since then, the market has seen a steady influx of new products, including hemp-infused teas, sparkling waters and protein shakes. Hemp seeds are rich in essential fatty acids, vitamins and proteins, making them an attractive beverage ingredient. State regulations also play a significant role in the hemp beverage market.
Regulation 52
52 
Novavax gets green light for updated COVID vaccine
pharmaphorum
OCTOBER 4, 2023
Novavax has been given the go-ahead by regulators in the US for an updated version of its COVID-19 vaccine that targets the XBB.1.5 The FDA has signed off on the new protein-based shot, which joins two XBB.1.5-directed variant of the coronavirus.
Vaccine 105
105 
Mapping Networks of Immune Genes Behind Autoimmune Diseases
XTalks
JULY 14, 2022
For example, when T cells (a type of white blood cells that fight off infections and cancer) are activated in our immune systems, thousands of proteins in these cells change. The proteins are interconnected and changes in one protein level can impact that of another.
Gene 98
98 
US FDA clears Transcenta’s IND for Rett syndrome treatment
Pharmaceutical Technology
JANUARY 24, 2023
The investigational adeno-associated virus (AAV) gene therapy candidate NGN-401 is claimed to be the first to deliver the full-length human MECP2 gene using the company’s Expression Attenuation via Construct Tuning (EXACT) gene regulation technology.
Gene Therapy 208
208 
Researchers identify key regulator of blood stem cell development
Scienmag
JANUARY 28, 2022
A protein that masterminds the way DNA is wrapped within chromosomes has a major role in the healthy functioning of blood stem cells, which produce all blood cells in the body, according to a new study from researchers at Weill Cornell Medicine. The protein, known as histone H3.3,
Regulation 57
57 
A study indicates that hair loss might be prevented by regulating stem cell metabolism
Scienmag
OCTOBER 13, 2020
In experiments conducted with mice, a research group active in Helsinki and Cologne, Germany, has demonstrated that a protein called Rictor holds a key role in the process. Hair follicle stem cells, which promote hair growth, can prolong their life by switching their metabolic state. The study was published in the Cell Metabolism journal.
Regulation 72
72 
Exercise hormone may modulate genes associated with replication of novel coronavirus
Scienmag
SEPTEMBER 22, 2020
Brazilian researchers observed that in uninfected adipocytes, the hormone irisin altered the expression of genes that regulate ACE-2, which encodes a protein to which the virus binds in order to invade human cells.
Hormones 97
97 
A special omega-3 fatty acid lipid will change how we look at the developing and ageing brain, researchers find
Medical Xpress
MAY 4, 2023
Scientists from Singapore have demonstrated the critical role played by a special transporter protein in regulating the brain cells that ensure nerves are protected by coverings called myelin sheaths.
Research 98
98 
Gritstone bio trumpets first data for ‘multivariant’ COVID jab
pharmaphorum
JANUARY 5, 2022
The new vaccine differs from the currently approved shots because it delivers antigens for both the spike protein and other proteins found in SARS-CoV-2. That could mean it is less susceptible to the loss of efficacy to vaccines that can occur when there are changes in the spoke protein – as witnessed with the new Omicron variant.
Protein 126
126 
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