XTalks

OCTOBER 8, 2024

The 2024 Nobel Prize in Physiology or Medicine has been awarded to American scientists Victor Ambros and Gary Ruvkun for their groundbreaking discovery of microRNA (or miRNA) and its role in post-transcriptional gene regulation. However, microRNAs can bind to this mRNA, preventing it from functioning.

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Regulation Genetics Scientist RNA 52

The Pharma Data

JUNE 14, 2023

Scientists discover small RNA that regulates bacterial infection People with weakened immune systems are at constant risk of infection. The mRNAs encode the proteins that do all the work in a cell, so by measuring a bacterium’s mRNA level, one can infer the bacterium’s behavior. aeruginosa infections. Source link: [link]

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RNA Regulation Scientist Bacteria 40

pharmaphorum

JANUARY 5, 2022

The new vaccine differs from the currently approved shots because it delivers antigens for both the spike protein and other proteins found in SARS-CoV-2. That could mean it is less susceptible to the loss of efficacy to vaccines that can occur when there are changes in the spoke protein – as witnessed with the new Omicron variant.

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Protein Vaccination Vaccine Immune Response 126

BioTech 365

FEBRUARY 25, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Super-resolution RNA imaging in live cells.Ribonucleic acid (RNA) is key to various fundamental biological processes. It transfers genetic information, translates it into proteins or supports gene regulation.

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RNA Genetics Protein Gene 40

pharmaphorum

NOVEMBER 23, 2020

AstraZeneca is preparing to file its COVID-19 vaccine with regulators after phase 3 trial results showed it is up to 90% effective. AZ made the announcemen t as the UK regulator reportedly gears up to make a decision on the rival vaccine from Pfizer and BioNTech, ahead of counterparts in the US and Europe.

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Vaccination Vaccine Regulation Protein 105

The Pharma Data

MARCH 7, 2022

By combining CRISPR technology with a protein designed with artificial intelligence (AI), it is possible to awaken individual dormant genes by disabling the chemical “off switches” that silence them. The chemical modifications that regulate gene activity are called epigenetic markers. Cas9 binds and uses RNA as an address-tag.

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Protein Gene Genome Genomics 52

Roots Analysis

OCTOBER 22, 2023

RNA therapeutics are a novel class of biopharmaceuticals that harness the power of RNA molecules for the treatment and prevention of a wide range of disorders, including oncological, and genetic disorders as well as infectious diseases. Non-coding RNAs include antisense oligonucleotides (ASOs) and RNA aptamers.

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RNA Protein Genetics Gene Expression 40

Delveinsight

SEPTEMBER 23, 2021

Boehringer stated that the Abexxa’s generation aims at cancer-specific proteins situated throughout the mobile versus proteins at the mobile membrane broadening the selection of possible cancer antigen objectives. 858 Therapeutics closes USD 60 Million series A round to drug RNA modulation. Jeffrey Stafford, Ph.D.,

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RNA Gene Therapy Gene Protein 61

Roots Analysis

OCTOBER 30, 2023

In the past few years, Next Generation RNA therapeutics have emerged as one of the key therapeutic modalities in the modern healthcare industry. These RNA based therapeutics play a crucial role in protein production and regulation of gene functions.

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RNA Vaccine Vaccination Development 40

Pharmaceutical Technology

FEBRUARY 1, 2023

As an RNA virus, like SARS-CoV-2, RSV is highly prone to mutations. However, specific antibody-resistant mutations have already been documented within the RSV- F protein after prophylactic administration of nirsevimab. This is concerning as nirsevimab was very recently approved in only two regions.

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Vaccine Vaccination Antibody Protein 162

The Pharma Data

MARCH 23, 2022

Polymerase is a viral protein that directs how Ebola virus replicates its genome as it infects new hosts. The researchers discovered that Ebola virus polymerase hijacks a cellular protein called GSPT1. To treat Ebola virus infections, researchers are taking a close look at a key piece of the virus: polymerase.

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Protein Genome Genomics Research 52

pharmaphorum

DECEMBER 1, 2020

Pfizer and BioNTech have filed their COVID-19 vaccine with the European medicines regulator, paving the way for a potential approval before the end of the year. The EMA has also confirmed it has received a filing from Moderna, which is producing a rival vaccine based on similar RNA technology.

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Vaccine Vaccination RNA Clinical Trials 88

pharmaphorum

MARCH 9, 2022

The XTEND-1 trial also showed that BIVV001 was better at reducing the annualised rate of bleeding episodes than patients’ previous therapies, according to Sanofi and Sobi, which said they will now talk to regulators to chart a path forward to approval. The half life of the new drug – one of the main draws for Sanofi’s $11.6

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Protein Gene Therapy Sales Regulation 98

XTalks

NOVEMBER 22, 2021

Related: How RNA-Based Pesticides Can Improve Pest Control. Once the army of Black Soldier flies has finished feasting, Bardee transforms the leftovers into “all-natural protein and oil for pet food, poultry and aqua feed and nutrient-rich organic fertilizers,” according to the company’s website.

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Protein RNA Engineer Production 98

pharmaphorum

APRIL 12, 2021

The companies have said that the vaccine could be quickly updated to counter emerging variants, with regulators prepared to accept smaller studies as safety has already been established in wider trials and real-world settings.

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Vaccine Vaccination RNA Protein 83

pharmaphorum

NOVEMBER 17, 2020

Pfizer is poised to file the vaccine with the FDA in the coming days, seeking an Emergency Use Authorization (EUA) after gathering enough safety data required by the regulator. Both Pfizer and Moderna vaccines use synthetic messenger RNA to activate the immune system against the virus. Pfizer and BioNTech have a $1.95

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Vaccine Vaccination RNA Clinical Trials 78

Pharmaceutical Technology

DECEMBER 9, 2022

Beyond our expertise in small molecules, we have built a solid reputation with biopharmaceutical companies for the characterisation and analysis of monoclonal antibodies, therapeutic proteins and biosimilars. Ribonucleic acid (RNA) based technologies are among many innovative approaches explored to tackle the Covid-19 pandemic.

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pharmaphorum

FEBRUARY 25, 2022

Prior to this latest development, research into the human ZGA was limited to human embryos at a later stage of growth, under stringent UK regulations. In the study, a subset of human ESCs with the right transcriptome – RNA code output – was found to be a potential match for the 8-cell stage, which is when most genome activation occurs.

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Research Genome Genomics Protein 69

pharmaphorum

MAY 11, 2021

Importantly the vaccine can be stored in a fridge, unlike the rivals from Pfizer/BioNTech and Moderna, which require storage at ultra-cool temperatures to maintain their delicate RNA structure. “I don’t believe we’re going to be able to make it by the end of June. .”

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Vaccine Vaccination RNA Regulation 64

pharmaphorum

JANUARY 6, 2021

million – including $175 million upfront and an equity investment of $50 million – to find multiple RNA interference (RNAi) candidates for diseases like non-alcoholic steatohepatitis (NASH) and type 2 diabetes. Danish drugmaker Novo Nordisk signed a deal with the US biotech in 2019 valued at up to $675.5

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Gene Silencing Gene RNA Contract Manufacturing 66

pharmaphorum

DECEMBER 16, 2020

Moderna looks odds on to claim emergency use authorisation from the FDA for its COVID-19 vaccine this week, after the regulator published a report endorsing its safety and rating its efficacy at 94.5%.

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Vaccine Vaccination Trials RNA 98

pharmaphorum

FEBRUARY 19, 2021

billion cumulative doses of its NVX-CoV2373 recombinant protein-based vaccine candidate, which is yet to be approved by regulators. It can be stored at standard refrigerator temperatures and does not require the ultra-cool supply chain required to maintain stability of RNA vaccines from Pfizer/BioNTech and Moderna.

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Vaccination Vaccine Manufacturing RNA 80

pharmaphorum

DECEMBER 21, 2020

But the tragic events of 2020 have meant these companies have become household names as their trailblazing mRNA vaccines became the first to be approved by regulators against the COVID-19 scourge. Their technology is based on synthetic messenger RNA – short for ribose nucleic acid – which is a short transcript of a longer DNA code.

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Vaccine Vaccination Doctor Doctors 111

pharmaphorum

NOVEMBER 18, 2021

The two companies have been working together since 2019 to develop multiple RNA interference (RNAi) candidates for disorders such as non-alcoholic steatohepatitis (NASH), type 2 diabetes, obesity and rare diseases. billion in cash.

Gene Silencing 52

Gene Silencing RNA Protein Gene 52

Pharmaceutical Technology

JUNE 4, 2023

Innovation S-curve for the pharmaceutical industry Transcription factors for genetically modified cells is a key innovation area in the pharmaceutical industry Transcription factors are proteins which control gene expression by controlling the rate of transcription of genetic information from DNA to RNA.

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Genetics Gene Expression DNA Antibody 130

pharmaphorum

NOVEMBER 9, 2020

Results will be discussed with regulators worldwide and the European Medicines Agency has already begun its rolling review of data to hasten a decision on the clinical trial dossier. The independent data monitoring committee that conducted the interim analysis said that there had been no serious safety concerns identified.

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Vaccine Vaccination Clinical Trials Clinical Trials 98

Roots Analysis

AUGUST 31, 2023

Further, the expression of any gene is dependent on the rate at which it is transcribed into mRNA and translated into proteins. There are various regulatory proteins or transcription factors that are responsible for affecting the transcription rate. When activator binds to the operon, it either speeds up or permits gene expression.

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Gene Gene Therapy Gene Expression Regulation 40

pharmaphorum

OCTOBER 6, 2020

The announcement comes just days after the regulator said its CHMP scientific committee had begun to look at the first batch of data from AZ’s rival. The vaccine is based on different technology from AZ’s rival: while AZ’s uses a weakened and genetically modified cold virus to prime the immune system, BNT162b2 is based on a string of RNA.

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Vaccine Vaccination RNA Immune Response 59

XTalks

APRIL 6, 2022

XTALKS WEBINAR: Using CRISPR interference (CRISPRi) Viability Screens to Map Long Noncoding RNA Dependencies in Tumor Cells. Register for this webinar to get an overview of the role of long non-protein coding RNAs (lncRNAs) in gene regulations. Live and On-Demand: Thursday, April 21, 2022, at 11am EDT (4pm BST/UK).

DNA 105

DNA In-Vitro Doctor Doctors 105

Pharmaceutical Technology

OCTOBER 28, 2022

There are many variabilities with biosimilars and the brand name protein drug.” Protein-based drugs are extremely expensive and so if you can create a biosimilar and potentially lower the cost, then this is an incentive for many companies to try to get into that marketplace, but also for regulators to encourage development.”.

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pharmaphorum

SEPTEMBER 21, 2020

The drug works by reducing the production of ApoC-III, a protein that regulates plasma triglycerides. Akcea – an affiliate of Ionis that is set to become a wholly-owned subsidiary shortly – specialises in antisense drugs that target RNA to prevent the expression of errant genes that cause diseases.

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Drugs RNA Medicine Genetics 80

pharmaphorum

DECEMBER 7, 2020

All the vaccines developed in China are inactivated, meaning they are made of proteins found on the surface of the coronavirus that produce a response that provides immunity in the event of an infection. This means they do not require the ultra-cool temperatures needed to store the RNA-based vaccines from Pfizer/BioNTech and Moderna.

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Vaccine Vaccination Production Clinical Development 59

pharmaphorum

JANUARY 20, 2021

The new variant identified in the UK in December shows significant mutations in the Spike protein and receptor binding domain that increase its infectivity. The variant that originated in South Africa carries a mutation in the Spike protein that has been shown to reduce antibody recognition and could therefore affect efficacy of new vaccines.

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Vaccination Vaccine Protein RNA 52

XTalks

AUGUST 12, 2020

Studies have identified the presence of two types of HIV-infected CD4+ T cells: ‘Transcriptionally inactive’ cells that do not typically produce viral RNA or viral proteins. Transcriptionally active’ cells in which HIV RNA is actively transcribed to make copies of the virus (despite long-term ART).

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RNA Protein DNA In-Vivo 52

Roots Analysis

MARCH 8, 2023

INTRODUCTION TO EXOSOMES Exosomes are extracellular vesicles, which have endosomal origin and may contain different biomolecules, including proteins, DNA, lipids, miRNA or RNA , based on the type of cell of their origin and its conditions. Exosomes convey a wide range of information to the target cells, depending on their source.

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RNA Drug Delivery DNA Development 52

The Pharma Data

JANUARY 21, 2021

Luckily, the new variants still rely on the coronavirus’ “spike protein” to infect cells, and the two COVID vaccines now on the U.S. market specifically target the spike protein to prevent transmission, explained Dr. Kathryn Edwards, scientific director of the Vanderbilt University Vaccine Research Program in Nashville.

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Vaccine Vaccination Protein Immune Response 52

The Pharma Data

MARCH 3, 2022

In 2018, Shalev and colleagues reported the benefits of verapamil in a one-year clinical study of Type 1 diabetes patients, finding that regular oral administration of verapamil enabled patients to produce higher levels of their own insulin, thus limiting their need for injected insulin to regulate blood sugar levels.

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Insulin Gene Expression Gene Protein 52