AuroBlog - Aurous Healthcare Clinical Trials blog

SEPTEMBER 8, 2024

(Tero Vesalainen/iStock/Getty Images) There’s still so much we don’t know about Alzheimer’s disease, but the link between poor sleep and worsening disease is one that researchers are exploring with gusto.

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Protein Scientist Research Clinical Trials 245

Bio Pharma Dive

JULY 28, 2022

Vicinitas and its protein-stabilizing research have attracted $65 million from a group of investors that includes a16z, Deerfield and GV.

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Protein Research 264

AuroBlog - Aurous Healthcare Clinical Trials blog

MARCH 7, 2024

Scientists have now demonstrated how stimulating high-frequency brain waves in mice can clear out the amyloid protein clumps associated with Alzheimer’s. Previous research has shown that stimulating high-frequency brain waves, called gamma waves, might improve the brain’s ability to clear […]

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Protein Scientist Research Clinical Trials 229

AuroBlog - Aurous Healthcare Clinical Trials blog

APRIL 28, 2024

Our bodies are alive with activity and packed with proteins jammed into fatty membranes or floating in and out of watery cells. Scientists have now, for the first time, captured the dance between the two: a liquid tango featuring proteins and fats as they would normally move in cells.

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Protein Scientist Clinical Trials Clinical Trials 185

Bio Pharma Dive

JUNE 14, 2023

The alliance is Astellas’ second recent partnership involving protein degraders, an emerging area of drug research the company has made a focus in recent years.

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Protein Drugs Research 182

Bio Pharma Dive

MAY 16, 2024

While results indicated the drug works as intended, it didn’t have enough of an effect on a protein that’s become integral to many ALS research programs.

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Drugs Protein Research 321

Pharmaceutical Technology

MARCH 17, 2023

The Lung Cancer Research Foundation (LCRF) has announced a new research partnership with Daiichi Sankyo and AstraZeneca. This collaboration is intended to fund up to three research grants that are focused on antibody-drug conjugates (ADCs) for improving the outcomes for lung cancer patients.

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Bio Pharma Dive

JUNE 16, 2022

The failure is an upset not only to Roche, but also a blow to the wider Alzheimer’s research field, which has for years kept focus on a protein called beta amyloid.

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Protein Research 343

Pharmaceutical Technology

AUGUST 29, 2024

The Putative Fidgetin Like Protein 2 pipeline drugs market research report outlays comprehensive information on the Putative Fidgetin Like Protein…

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Protein Drugs Development Marketing 130

Bio Pharma Dive

JULY 26, 2022

But an apparent effect on a protein of interest in ALS research has Biogen convinced the treatment will pass muster with regulators. Known as tofersen, the drug failed in the main study being used to support its approval.

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Drugs Protein Regulation Research 328

Bio Pharma Dive

FEBRUARY 16, 2023

The company’s platform technology is built on research from Zhang’s lab at the Broad Institute, which focuses on a proteins that could be used to package and deliver nucleic acids.

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Bio Pharma Dive

NOVEMBER 13, 2020

An alliance with BeyondSpring spinout Seed Therapeutics makes Eli Lilly the latest pharma company to dive into the fast-emerging drug research field.

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Protein Pharma Companies Drugs Research 243

Bio Pharma Dive

MARCH 30, 2021

Two drugs developed by Wave Life Sciences didn't appear to have an effect on disease-causing proteins, another setback for Huntington's research after disappointing results last week from Roche and Ionis.

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Life Science Drugs Protein Trials 317

Bio Pharma Dive

MAY 19, 2023

The biotech, best known for its vaccine research, said its clinical trial is the first to report results of a messenger RNA therapeutic designed for intracellular protein replacement.

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RNA Medicine Clinical Trials Clinical Trials 305

Bio Pharma Dive

JUNE 23, 2022

After one year, researchers detected important protein changes in patients who received a low dose of the experimental treatment. Further testing and functional data are needed to assess its potential, however.

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Gene Therapy Gene Protein Research 299

Pharmaceutical Technology

FEBRUARY 13, 2023

While several therapeutics are available for treating symptoms associated with epilepsy, researchers and patients have strongly called out the need for more holistic treatments that would address the condition as a whole. Meanwhile, others are researching the link between gene variation and different responses to treatments.

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Research Gene Gene Therapy Genomics 264

Pharmaceutical Technology

DECEMBER 5, 2022

Sanofi has signed an agreement with the Queensland Government in Australia to establish a $190m (A$280m) research facility in Brisbane. The hub will connect Queensland scientists with the teams at Sanofi’s mRNA Centre of Excellence in the US and France, putting them at the front of international vaccine development and biomedical research.

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Research Gene Therapy Vaccine Vaccination 246

Pharmaceutical Technology

JULY 25, 2023

Astellas Pharma has entered a research partnership and licence agreement with PeptiDream for the discovery of new targeted protein degraders.

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Protein Research 130

Bio Pharma Dive

SEPTEMBER 20, 2023

Targeted protein degradation has emerged as one of the more competitive areas of pharmaceutical research in recent years as scientists develop new ways to reach difficult-to-drug targets.

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Drugs Protein Scientist Development 280

Pharmaceutical Technology

FEBRUARY 16, 2023

Aqilion and Merck have entered an exclusive licence and strategic research partnership for the discovery, development and commercialisation of the transforming growth factor-β-activated kinase 1 (TAK1) protein-small molecule inhibitors.

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Protein Development Sales Business Development 147

Pharmaceutical Technology

JUNE 15, 2023

Japan-based Astellas Pharma has entered a partnership with Cullgen to discover and develop multiple targeted protein degraders through the latter’s proprietary uSMITE targeted protein degradation platform, in a deal potentially worth $1.9bn. This method can target enzymes, transcription factors, scaffold proteins and more.

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Protein Development Licensing Licensing 130

Pharmaceutical Technology

AUGUST 5, 2022

As per the prevailing prion theory, a misfolded version of a normal cell-surface protein acts as the chief infectious agent. Adding to this, the infectivity of prion diseases also makes research challenging, says Wille. This means that the removal of M cells could prevent the accumulation of prion proteins in the body.

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Drugs Protein Vaccine Vaccination 299

AuroBlog - Aurous Healthcare Clinical Trials blog

APRIL 29, 2024

A unique genetic mutation in two siblings – that has never been seen in anyone else – has been discovered by UK researchers at the University of Exeter, pointing the way towards new treatment options for type 1 diabetes. The mutation is in the gene for a protein called programmed death-ligand 1 (PD-L1), and a […]

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Gene Genetics Protein Research 233

Pharma Times

APRIL 29, 2024

The new process makes generating active pharmaceutical ingredients quicker and easier

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Protein Development Research Drugs 142

Pharmaceutical Technology

MARCH 21, 2023

Gilead Sciences has exercised its option to exclusively license the investigational targeted protein degrader development candidate, NX‑0479, from clinical-stage biopharmaceutical company Nurix Therapeutics. GS-6791 is the first development candidate from the previous collaboration between Gilead Sciences and Nurix in 2019.

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Protein Licensing Licensing Sales 130

AuroBlog - Aurous Healthcare Clinical Trials blog

JULY 24, 2024

We’ve known for over a century that mice and rats live longer when they are fed less, but a new study reveals the secret might be an imbalance between energy consumed and burned, rather than a lack of energy or protein. Researchers from the US and UK studied groups of mice put on identical diets, […]

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Protein Research Clinical Trials Clinical Trials 243

Pharmaceutical Technology

MAY 15, 2023

In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Immuno-oncology in Pharmaceuticals: Oncolytic viral proteins. Sillajen and Advaxis are the other key patent filers of oncolytic viral proteins.

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Protein Gene Genetics Gene Therapy 130

Pharmaceutical Technology

OCTOBER 18, 2022

Last week, Nature magazine published a paper detailing an in-situ study of Parkinson’s disease (PD), showing protein structural changes in cerebrospinal fluid (CSF) between healthy individuals and Parkinson’s patients. In PD clinical research, many biomarkers, such as neurofilament, can be measured within the CSF using a lumbar puncture.

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Protein Genetics Gene Clinical Research 264

AuroBlog - Aurous Healthcare Clinical Trials blog

JUNE 19, 2024

(Peter Dazeley/The Image Bank/Getty Images) Our body’s circadian clock affects everything from sleepiness to metabolism – and it might also influence how effective certain cancer treatments are, according to recent research.

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Scientist Protein Drugs Research 242

AuroBlog - Aurous Healthcare Clinical Trials blog

FEBRUARY 19, 2024

A detailed look at minute differences in the levels of specific proteins in blood has allowed researchers to identify potential early warning signs of dementia.

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Protein Research Clinical Trials Clinical Trials 237

AuroBlog - Aurous Healthcare Clinical Trials blog

NOVEMBER 1, 2023

The team, led by researchers from Stanford University, adapted a technique used for analyzing eye fluid. Almost 6,000 proteins detected in the fluid could be traced […]

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Protein Scientist Research Development 238

Pharma Times

JULY 26, 2024

Researchers predicted the onset of 67 diseases, out-performing current standard models

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Protein Development Research Biobanking 137

AuroBlog - Aurous Healthcare Clinical Trials blog

AUGUST 22, 2024

Neurons aren’t the only brain cells producing the proteins associated with Alzheimer’s disease, a new study of mouse models reveals. Amyloid beta proteins occur naturally in our brains, but have long, and now controversially, been associated with Alzheimer’s disease. “Until now, neurons were […]

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Protein Clinical Trials Clinical Trials Clinical Research 238

Bio Pharma Dive

DECEMBER 1, 2022

Detailed clinical trial data for Roche's gantenerumab showed treatment cleared far less toxic protein from patients' brains than expected, potentially explaining its divergent result from Eisai’s lecanemab.

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Clinical Trials Clinical Trials Protein Research 173

AuroBlog - Aurous Healthcare Clinical Trials blog

APRIL 2, 2024

Alzheimer’s disease is commonly associated with clumps and tangles of proteins building up in brain cells. A study led by researchers from the Stanford University School of Medicine returned to observations of large fat drops […]

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Protein Medicine Research Clinical Trials 207

Pharma Times

DECEMBER 20, 2023

Researchers from Johns Hopkins University School of Medicine have revealed new findings about a key pathological protein associated with Parkinson’s disease (PD), which could lead to new treatments. However, its relation to dopaminergic neuron death is unclear.

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Protein Medicine Engineer Genetics 99

pharmaphorum

MARCH 13, 2024

Basecamp Research launches BaseFold, a deep learning model that it says surpasses benchmark tool AlphaFold2 and should accelerate AI-based drug discovery.

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Protein Research Drugs 89