Medical Xpress

MAY 18, 2023

Our bodies burn carbohydrates, proteins, and fat for fuel, and now, researchers at the Broad Institute of MIT and Harvard and the University of Lausanne have discovered another important energy source for cells: uridine, the chemical building block unique to RNA.

RNA 98

RNA Protein Research 98

Medical Xpress

MAY 16, 2023

Researchers at the University Medical Center Hamburg-Eppendorf have demonstrated cross-reactive immune responses to another SARS-CoV-2 protein besides the spike protein.

Protein 98

Protein Immune Response RNA Research 98

Scienmag

NOVEMBER 11, 2020

Credit: Masato Kanemaki Researchers can now more accurately and precisely target specific proteins in yeast, mammalian cells and mice to study how knocking down specific protein traits can influence physical manifestation in a cell or organism. “Conditional gene knockout and small interfering RNA […]. .

Protein 98

Protein Genetics RNA Development 98

Pharmaceutical Technology

DECEMBER 23, 2022

This alliance is utilising the Axiomer ribonucleic acid (RNA) editing platform of ProQR to address ailments affecting the liver and nervous system. Eli Lilly and Company has expanded a licencing and partnership agreement with ProQR Therapeutics to discover, develop and market new genetic medicines.

Genetics 328

Genetics Medicine Development Gene Therapy 328

Scienmag

NOVEMBER 13, 2020

In a screening for a functional impact to the neuronal differentiation process, Danish researchers identified a specific circular RNA, circZNF827, which surprisingly “taps the brake” on neurogenesis.

RNA 93

RNA Regulation Protein Production 93

Pharmaceutical Technology

APRIL 20, 2023

Targovax has unveiled plans to rebrand as Circio , reflecting its strategic shift to focus on expediting the development of its innovative circular RNA (circRNA) platform. Initially reported in 2011, CircRNA is a naturally occurring class of RNA.

Gene Therapy 240

Gene Therapy RNA Gene Development 240

World of DTC Marketing

DECEMBER 29, 2020

Both the Pfizer and Moderna vaccines copied RNA sequence from the virus genome and found a way to manufacture it at scale with high-level processes and quality control. The coronavirus vaccines, however, took less than a year. First, a novel approach was used that didn’t require traditional vaccine production in cell cultures or eggs.

Vaccination 307

Vaccination Vaccine Development Clinical Trials 307

Scienmag

MAY 7, 2021

Credit: UPMC PITTSBURGH, May 7, 2021 – In a paper published today in Nature Communications, an international group of collaborators led by researchers at UPMC Children’s Hospital of Pittsburgh have identified a genetic cause of a rare neurological disorder marked by developmental delay and loss of coordination, or ataxia.

Genetics 95

Genetics Genetic Disease RNA Protein 95

Scienmag

MARCH 4, 2021

Findings explain how plants use RNA to defend against fungal invaders Credit: Nicole Ward Gauthier/University of Kentucky New research reveals an essential step in scientists’ quest to create targeted, more eco-friendly fungicides that protect food crops.

Protein 95

Protein RNA Scientist Manufacturing 95

Medical Xpress

FEBRUARY 6, 2023

Such was the case with Brian Kraemer's research team and their recent study of the protein tau and its impact on dementia diseases. Sometimes in science, "Eureka!" moments happen with surprisingly little effort. Sometimes they take years or decades to emerge.

RNA 98

RNA Protein Research 98

Pharmaceutical Technology

MAY 8, 2023

Innovation S-curve for the pharmaceutical industry ssRNA virus peptides is a key innovation area in pharmaceutical Single-stranded RNA (ssRNA) viruses establish a platform for viral replication in the cytoplasm during the early stages of infection and efficiently generate mature virus.

RNA 240

RNA Genetics Vaccination Vaccine 240

Scienmag

AUGUST 20, 2020

Some of these structures, such as those found in DNA, RNA and proteins, are formed through complex molecular interactions that are not easily duplicated by inorganic materials. A research team led by Richard Robinson, associate professor of materials science and engineering, discovered a […].

Research 75

Research RNA DNA Engineer 75

Pharma Mirror

FEBRUARY 17, 2022

The importance of exosomes in skin cell regeneration has been extensively researched over the past few years. The enhanced communication means that exosomes can facilitate the transfer of RNA, cytokines, growth factors, and specific proteins like keratin. All of these are necessary for the skin to rejuvenate itself.

RNA 130

RNA Protein Research 130

Pharmaceutical Technology

FEBRUARY 3, 2023

Since HIV integrates with the DNA, eliminating the virus from the body is very difficult, explains David Montefiori, PhD, director of the Laboratory for AIDS Vaccine Research and Development at Duke University in Durham, North Carolina. But others in the research space are now testing out other concepts that have been largely theoretical.

Vaccination 293

Vaccination Vaccine Antibody Trials 293

pharmaphorum

SEPTEMBER 1, 2020

The world of drug discovery and chemical probes is still protein-centric and developing highly selective small molecules targeting RNA is often considered to be an insurmountable challenge. Why You Should Attend the RNA- Targeted Drug Discovery Summit. The post 3rd RNA-Targeted Drug Discovery Summit appeared first on.

RNA 52

RNA Drugs Protein Clinical Development 52

Pharmaceutical Technology

MAY 25, 2023

The technology platforms include the Life Edit gene editing platform, an RNA, cell, protein, vector engineering and induced pluripotent stem cells (iPSCs) platform. New investors included research and development partner Novo Nordisk, Lee Family Office (Asia) and Woodline.

Gene Therapy 243

Gene Therapy Gene Gene Editing Development 243

Pharmaceutical Technology

JUNE 23, 2022

Researchers at the University of New Hampshire (UNH) have found that a repurposed drug, CCG-50014, could hinder the activity of a key enzyme of the SARS-CoV-2 virus, which causes Covid-19. Mpro has become the main focus of intense research and treatment development as it is vital for viral replication.

Drugs 130

Drugs Protein Genome Genomics 130

pharmaphorum

MAY 14, 2021

Biogen has made a further push into RNA-based drug discovery via a collaboration with Envisagenics, which applies artificial intelligence RNA sequencing data to discover new drug targets and therapeutics. It’s not the first partnership for Biogen in the RNA splicing area.

RNA 60

RNA Licensing Licensing Genetics 60

Worldwide Clinical Trials

AUGUST 14, 2024

Molecular Biomarkers : Encompass various molecules, such as RNA and metabolites, to reflect the physiological state of the cells and their disease pathways. Protein-based Biomarkers : Include proteins found in blood, tissues, or other bodily fluids that can indicate disease presence or progression.

Genetics 195

Genetics Protein Gene Genotype 195

XTalks

OCTOBER 21, 2020

The answer may lie in the genetic code of the virus, which scientists at Duke University have found contains several silent mutations that affect protein folding. The researchers focused on the spike proteins that protrude from the surface of the coronavirus, which are responsible for viral attachment and entry into host cells.

RNA 98

RNA Protein Genome Genomics 98

pharmaphorum

JANUARY 26, 2023

Both long- and short-read sequencing today is faster, more affordable, and highly accurate, providing researchers with deep insights to fuel research. Moreover, research has shown that genetic testing can reduce adverse reactions to drugs by nearly one third. Just one mutation can lead to a complete change in protein formation.

Genome 129

Genome Genomics Genome Project Genetics 129

BioTech 365

JULY 6, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Lilly invests in MiNA to fund trials of protein-upregulating RNA.Lilly invests in MiNA to fund trials of protein-upregulating RNA ntaylor Tue, 07/06/2021 – 07:58 from FierceBiotech: Biotech … Continue reading → (..)

RNA 40

RNA Protein Trials Research 40

Camargo

JULY 27, 2021

The technology of gene therapy is possible due to extensive DNA research and our resulting understanding of many diseases on the genetic level, and it encompasses several mechanisms such as introducing new genes (gene addition) and inactivating or replacing mutated genes (gene editing). Route of Administration Considerations.

Gene Therapy 238

Gene Therapy Gene Gene Editing Genetics 238

BioTech 365

MAY 10, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Flagship debuts Laronde to develop RNA-based meds that could turn cells into protein factories.Flagship debuts Laronde to develop RNA-based meds that could turn cells into protein factories … Continue reading →

RNA 40

RNA Protein Development Research 40

BioTech 365

JULY 2, 2021

Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: New approach to triple-negative breast cancer targets tumor-driving RNA proteins.New approach to triple-negative breast cancer targets tumor-driving RNA proteins arlene.weintraub Fri, 07/02/2021 – 08:49 from FierceBiotech: (..)

RNA 40

RNA Protein Research 40

Scienmag

FEBRUARY 10, 2022

Also known as transcriptional activators for their ability to induce transcription of genes into RNA messages, these proteins are essential for the cells to function properly. Yet little is known about these proteins, and it wasn’t clear how many activators there might be in human cells – until now.

Gene 59

Gene Research RNA Protein 59

Pharmaceutical Technology

JULY 5, 2022

Researchers at the UNC School of Medicine have discovered that hepatitis A virus (HAV) replication needs particular interactions between the human protein ZCCHC14 and TENT4 poly(A) polymerases, a group of enzymes. In addition, the scientists later found that the HAV needs TENT4A/B for its replication.

Protein 130

Protein RNA Genomics Genome 130

pharmaphorum

AUGUST 31, 2021

Just a few months after breaking cover with its new take on RNA therapeutics, Laronde has raised an impressive $440 million in second-round financing backed by Flagship Pioneering – which was behind the founding of mRNA specialist Moderna. The post ‘Endless RNA’ startup Laronde raises $440m to fuel pipeline appeared first on.

RNA 52

RNA Protein Immune Response Medicine 52

pharmaphorum

JANUARY 5, 2022

The new vaccine differs from the currently approved shots because it delivers antigens for both the spike protein and other proteins found in SARS-CoV-2. That could mean it is less susceptible to the loss of efficacy to vaccines that can occur when there are changes in the spoke protein – as witnessed with the new Omicron variant.

Protein 126

Protein Vaccination Vaccine Immune Response 126

Scienmag

NOVEMBER 1, 2020

Scientists from an international group led by the RIKEN Center for Integrative Medical Sciences and Yokohama City University have discovered that a pair of proteins play a key role in allowing an important type of functional non-coding RNA, known as SINEUPs, to act to promote their target messenger RNA.SINEUPs are a recently discovered type of […]. (..)

Protein 45

Protein Production RNA Research 45

Pharmaceutical Technology

NOVEMBER 22, 2022

Devex’s global COVID-19 funding dashboard recorded $172 million invested in vaccine research between 1 January 2020 and 27 June 2020. Research into the therapeutic use of mRNA had been ongoing for decades prior to the COVID-19 pandemic. This August, the Biomedical Advanced Research and Development Authority awarded Arcturus $63.2

Manufacturing 130

Manufacturing Vaccination Vaccine RNA 130

Scienmag

DECEMBER 13, 2021

Researchers at Vanderbilt University Medical Center have discovered a nanoparticle released from cells, called a “supermere,” which contains enzymes, proteins and RNA associated with multiple cancers, cardiovascular disease, Alzheimer’s disease and even COVID-19.

RNA 76

RNA Containment Protein Research 76

Roots Analysis

OCTOBER 22, 2023

RNA therapeutics are a novel class of biopharmaceuticals that harness the power of RNA molecules for the treatment and prevention of a wide range of disorders, including oncological, and genetic disorders as well as infectious diseases. Non-coding RNAs include antisense oligonucleotides (ASOs) and RNA aptamers.

RNA 40

RNA Protein Genetics Gene Expression 40

pharmaphorum

FEBRUARY 25, 2022

A new stem cell model, discovered by researchers exploring the human genome, will help scientists to map out the key genomic changes during early development. Prior to this latest development, research into the human ZGA was limited to human embryos at a later stage of growth, under stringent UK regulations.

Research 69

Research Genome Genomics Protein 69

The Pharma Data

MARCH 7, 2022

By combining CRISPR technology with a protein designed with artificial intelligence (AI), it is possible to awaken individual dormant genes by disabling the chemical “off switches” that silence them. Researchers from the University of Washington School of Medicine in Seattle describe this finding in the journal Cell Reports.

Protein 52

Protein Gene Genome Genomics 52

Scienmag

JULY 1, 2021

Almost twenty years ago, the process of RNA silencing was discovered in plants, whereby small fragments of RNA inactivate a portion of a gene during protein synthesis.

RNA 60

RNA Protein Research Gene 60

XTalks

DECEMBER 22, 2021

The RNA Revolution: From mRNA Vaccines to RNA Editing. The age of RNA is officially here, and it’s here to stay as more than a passing life science trend. percent, according to a report by BCC Research. RNA technology is not new nor has its potential been surprising. RNA in the Making. RNA Therapeutics.

Life Science 98

Life Science RNA Vaccination Vaccine 98