Two RNA-binding proteins could contribute to cancer therapy development
Pharma Times
APRIL 26, 2024
The paper identifies the roles of LARP4A and LARP4B in sarcoma and carcinoma cancers
RNA editing protein ADAR1 protects telomeres and supports proliferation in cancer cells
Scienmag
MARCH 12, 2021
Credit: The Wistar Institute PHILADELPHIA — (March 12, 2021) — Scientists at The Wistar Institute identified a new function of ADAR1, a protein responsible for RNA editing, discovering that the ADAR1p110 isoform regulates genome […].
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Merck and Orna partner for RNA technology-based vaccines and therapies
Pharmaceutical Technology
AUGUST 17, 2022
Merck (MSD outside North America) has entered a partnership agreement with Orna Therapeutics for discovering, developing and marketing various programmes based on next-generation RNA technology. By self-circularisation, Orna’s oRNA technology makes circular ribonucleic acids (oRNAs) from linear RNAs.
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Biogen, Ionis tout data from early study of RNA-based Alzheimer's drug
Bio Pharma Dive
JULY 27, 2021
The companies said that patients treated with their experimental drug BIIB080 had reductions in a protein called tau, which research indicates is tied to Alzheimer's but isn't yet proven to impact the course of the disease.
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RNA holds the reins in bacteria: U-M researchers observe RNA controlling protein synthesis
Scienmag
APRIL 14, 2021
Credit: Surajit Chatterjee To better understand how RNA in bacteria gives rise to protein–and along the way, target these processes in the design of new antibiotics–researchers are turning their attention to the unique way this process happens in bacteria.
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Potential drug target for difficult-to-treat breast cancer: RNA-binding proteins
Scienmag
JULY 2, 2021
Studies using human cell lines and tumors grown in mice provide early evidence that inhibiting RNA-binding proteins, a previously overlooked family of molecules, might provide a new approach for treating some cancers Credit: UC San Diego Health Sciences In cancer research, it’s a common goal to find something about cancer cells — some sort (..)
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Radical Study Proposes a Single Cause to Explain Alzheimer’s Disease
AuroBlog - Aurous Healthcare Clinical Trials blog
FEBRUARY 11, 2025
Researchers from Arizona State University suggest that stress granules protein and RNA clumps that form around cells in stressful […]
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ORI Capital, the venture firm behind CG’s big IPO, raises new biotech fund
Bio Pharma Dive
FEBRUARY 22, 2024
The $260 million fund will be used to back startups working on new drugmaking approaches like protein degraders and RNA therapies.
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Lilly buys into MiNA’s protein-boosting RNA tech in $1.25bn deal
pharmaphorum
MAY 12, 2021
UK biotech MiNA Therapeutics has signed up another big pharma partner for its small activating RNA (saRNA) platform, which upregulates the activity of proteins, with Eli Lilly the latest to get in on the action. . The post Lilly buys into MiNA’s protein-boosting RNA tech in $1.25bn deal appeared first on.
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STAT+: A new suite of RNA-sensing tools could help scientists target cancerous cells, and much more
STAT News
OCTOBER 27, 2022
That stands for “adenosine deaminases acting on RNA.” But this RNA-editing class of proteins, made by all multicellular organisms, is starting to have its moment in the bioengineering sun. Sure, you’ve heard of CRISPR. But it’s 2022. The acronym you need to know now is ADARs.
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Chinook and Ionis partner to develop ASO therapy for kidney disease
Pharmaceutical Technology
MAY 17, 2023
It will use the precision medicine approach, as well as the deep expertise of Chinook Therapeutics in nephrology and knowledge of Ionis Pharmaceuticals in RNA-targeted therapeutics. Antisense therapies are designed for destroying mRNA, reducing the amount of disease-causing protein.
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Locanabio’s RNA-Targeting Gene Therapy May Offer Durable Response for DM1 Patients
BioSpace
SEPTEMBER 22, 2020
RNA-binding proteins are emerging as the next generation of molecular medicine.
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Untangling the Body’s Smart Sensors: What RNA Binding Proteins Can Tell Us About Gene Regulation
BioSpace
SEPTEMBER 11, 2020
I certainly can’t, but Eclipse BioInnovations, a San Diego-based biotech start-up, is aiming to do just that for RNA therapeutics. Can you imagine organizing more than 10 terabytes of data into a useful network of information, like creating Google maps from scratch?
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Cells can use uridine, a component of RNA, as a source of energy
Medical Xpress
MAY 18, 2023
Our bodies burn carbohydrates, proteins, and fat for fuel, and now, researchers at the Broad Institute of MIT and Harvard and the University of Lausanne have discovered another important energy source for cells: uridine, the chemical building block unique to RNA.
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Genetic eraser: Newly developed technology precisely and rapidly degrades targeted proteins
Scienmag
NOVEMBER 11, 2020
Credit: Masato Kanemaki Researchers can now more accurately and precisely target specific proteins in yeast, mammalian cells and mice to study how knocking down specific protein traits can influence physical manifestation in a cell or organism. “Conditional gene knockout and small interfering RNA […].
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Study: Infection with common cold coronaviruses can trigger broad cross-immunity against SARS-CoV-2 proteins
Medical Xpress
MAY 16, 2023
Researchers at the University Medical Center Hamburg-Eppendorf have demonstrated cross-reactive immune responses to another SARS-CoV-2 protein besides the spike protein.
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Circular RNA regulates neuronal differentiation by scaffolding an inhibitory transcription complex
Scienmag
NOVEMBER 13, 2020
In a screening for a functional impact to the neuronal differentiation process, Danish researchers identified a specific circular RNA, circZNF827, which surprisingly “taps the brake” on neurogenesis.
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US FDA grants Fast Track status for Avidity’s AOC 1020 to treat FSHD
Pharmaceutical Technology
JANUARY 19, 2023
This DUX4 protein abnormal expression leads to modifications in gene expression in muscle cells which are associated with progressive muscle function loss in FSHD patients. Avidity Biosciences’ AOC 1020 is intended to reduce the DUX4 mRNA and DUX4 protein expression in muscles in these patients.
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Lilly and ProQR to expand genetic medicine development agreement
Pharmaceutical Technology
DECEMBER 23, 2022
This alliance is utilising the Axiomer ribonucleic acid (RNA) editing platform of ProQR to address ailments affecting the liver and nervous system. Eli Lilly and Company has expanded a licencing and partnership agreement with ProQR Therapeutics to discover, develop and market new genetic medicines.
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???????Research sheds light on mysterious messenger RNA modifications
Scienmag
MARCH 9, 2022
A team led by scientists at the University of Birmingham has come a step closer to uncovering the purpose of a distinctive set of modifications found at the beginning of messenger RNA which have long remained a fundamental mystery in molecular biology. Messenger RNAs (mRNAs) are vital for protein production.
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Transient expression of RNA for CAR T-cell therapies: An emerging opportunity for lipid nanoparticles
Pharmaceutical Technology
JANUARY 30, 2024
By enabling mRNA delivery for transient protein expression, lipid nanoparticles could address key challenges facing CAR T-cell therapies.
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Circular RNA Will Soon Replace mRNA in Biopharma
BioSpace
JULY 30, 2024
The advantages of using circular RNAs—including increased durability, enhanced protein expression, and substantially lower manufacturing costs compared to linear mRNAs—have driven a spate of investment in this technology.
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NSF backs bioinformatics approach to understanding plant RNA modifications
Scienmag
AUGUST 4, 2020
Led by Boyce Thompson Institute’s Andrew Nelson, four partners will identify RNA modifications and develop resources that may lead to hardier crops Credit: Photo credit: Anna Nelson Dittrich ITHACA, NY, August 4, 2020 — RNA perform a variety of functions in cells, helping with everything from regulating genes to building proteins.
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How did pharma develop a vaccine so quickly?
World of DTC Marketing
DECEMBER 29, 2020
Both the Pfizer and Moderna vaccines copied RNA sequence from the virus genome and found a way to manufacture it at scale with high-level processes and quality control. The coronavirus vaccines, however, took less than a year. First, a novel approach was used that didn’t require traditional vaccine production in cell cultures or eggs.
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Newly discovered RNA molecules hold promise for detecting and treating esophageal cancer
Medical Xpress
MAY 15, 2023
Irregularities in the body's genetic coding to make proteins are linked to cancerous tumors. But most genetic material contains elements whose function isn't clear.
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Rare genetic disease caused by mutations in protein that controls RNA metabolism
Scienmag
MAY 7, 2021
Credit: UPMC PITTSBURGH, May 7, 2021 – In a paper published today in Nature Communications, an international group of collaborators led by researchers at UPMC Children’s Hospital of Pittsburgh have identified a genetic cause of a rare neurological disorder marked by developmental delay and loss of coordination, or ataxia.
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New study reveals how lung cells protect themselves against RNA viral infection
Medical Xpress
FEBRUARY 22, 2023
A new University of California, Irvine-led study uncovers how a protein called APOBEC3B could protect cells against many different types of RNA viruses like respiratory syncytial virus (RSV), SARS-CoV2, influenza virus, poliovirus and measles, helping to prevent disease. The study was published in Nature Communications.
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Protein discovery could help enable eco-friendly fungicides
Scienmag
MARCH 4, 2021
Findings explain how plants use RNA to defend against fungal invaders Credit: Nicole Ward Gauthier/University of Kentucky New research reveals an essential step in scientists’ quest to create targeted, more eco-friendly fungicides that protect food crops.
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Overlooked tau-RNA interaction may play key role in dementia
Medical Xpress
FEBRUARY 6, 2023
Such was the case with Brian Kraemer's research team and their recent study of the protein tau and its impact on dementia diseases. moments happen with surprisingly little effort. Sometimes they take years or decades to emerge.
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3rd RNA-Targeted Drug Discovery Summit
pharmaphorum
SEPTEMBER 1, 2020
The world of drug discovery and chemical probes is still protein-centric and developing highly selective small molecules targeting RNA is often considered to be an insurmountable challenge. Why You Should Attend the RNA- Targeted Drug Discovery Summit. The post 3rd RNA-Targeted Drug Discovery Summit appeared first on.
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Biogen taps Envisagenics’ AI to speed up RNA splicing R&D
pharmaphorum
MAY 14, 2021
Biogen has made a further push into RNA-based drug discovery via a collaboration with Envisagenics, which applies artificial intelligence RNA sequencing data to discover new drug targets and therapeutics. It’s not the first partnership for Biogen in the RNA splicing area.
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3 Exosome Services And Technologies For Skin Regeneration
Pharma Mirror
FEBRUARY 17, 2022
The enhanced communication means that exosomes can facilitate the transfer of RNA, cytokines, growth factors, and specific proteins like keratin. Exosomes have another essential function, and that would be intercellular communication. All of these are necessary for the skin to rejuvenate itself.
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US FDA grants Fast Track status for Pfizer-BioNTech’s combination vaccine
Pharmaceutical Technology
DECEMBER 11, 2022
The first subject was dosed in the trial, which is designed to evaluate the safety, tolerability and immunogenicity of a nucleoside-modified RNA-based combination vaccine approach. 5 Omicron sublineages spike proteins.
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The Vital Role of Biomarkers in Neurodegenerative Pathways Early Phase Unit, Worldwide Clinical Trials
Worldwide Clinical Trials
APRIL 15, 2025
Despite their clinical heterogeneity, these diseases often share overlapping pathological mechanisms, including protein misfolding and aggregation, synaptic dysfunction, neuroinflammation, and axonal degeneration. Elevated NfL levels in CSF and serum correlate with disease activity, brain atrophy, and long-term disability.
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Ribometrix and Genentech Partner in Potential $1 Billion+ RNA Deal
The Pharma Data
JANUARY 5, 2021
Durham, North Carolina-based Ribometrix announced a strategic collaboration deal with Genentech , a Roche company, to identify and advance novel RNA-targeted small molecule therapeutics. Targeting RNA is believed to be a way to develop therapeutics for so-called undruggable proteins. The first identifies the 3D RNA motifs.
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ElevateBio raises funds to advance cell and gene therapies
Pharmaceutical Technology
MAY 25, 2023
The technology platforms include the Life Edit gene editing platform, an RNA, cell, protein, vector engineering and induced pluripotent stem cells (iPSCs) platform. ElevateBio intends to use the funds to advance its genetic medicine current good manufacturing practice (cGMP) and process development business, BaseCamp.
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With Cryo-EM, Sloan Kettering Institute scientists determine structure of key factor in RNA quality control
Scienmag
JUNE 9, 2022
A buildup of cells, proteins, or other molecules that are no longer needed can cause problems, so living things have evolved several ways to clean house. NEW YORK, JUNE 9, 2022 – In biology, getting rid of stuff can be just as important as making it. Credit: Memorial Sloan Kettering Cancer Center NEW YORK, JUNE […].
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#news #biotech Lilly invests in MiNA to fund trials of protein-upregulating RNA
BioTech 365
JULY 6, 2021
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Lilly invests in MiNA to fund trials of protein-upregulating RNA.Lilly invests in MiNA to fund trials of protein-upregulating RNA ntaylor Tue, 07/06/2021 – 07:58 from FierceBiotech: Biotech … Continue reading → (..)
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#news #biotech New approach to triple-negative breast cancer targets tumor-driving RNA proteins
BioTech 365
JULY 2, 2021
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: New approach to triple-negative breast cancer targets tumor-driving RNA proteins.New approach to triple-negative breast cancer targets tumor-driving RNA proteins arlene.weintraub Fri, 07/02/2021 – 08:49 from FierceBiotech: (..)
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#news #biotech Flagship debuts Laronde to develop RNA-based meds that could turn cells into protein factories
BioTech 365
MAY 10, 2021
Biotechnology, Pharma and Biopharma News – Research – Science – Lifescience ://Biotech-Biopharma-Pharma: Flagship debuts Laronde to develop RNA-based meds that could turn cells into protein factories.Flagship debuts Laronde to develop RNA-based meds that could turn cells into protein factories … Continue reading →
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CAMP4 raises $100m to take lead RNA drugs into clinic
pharmaphorum
JULY 20, 2022
Armed with a $100 million second-round financing, CAMP4 Therapeutics is preparing to start the first clinical trial of a drug targeting regulatory RNA (regRNA) molecules that can be used to fine-tune the expression of genes. ” The post CAMP4 raises $100m to take lead RNA drugs into clinic appeared first on. .
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NEW Thermo Invitrogen Qubit 4 DNA RNA Oligo Ion Protein Fluorometer w/Warranty
BioTech 365
AUGUST 10, 2020
$2,950.00End Date: Monday Aug-31-2020 14:55:52 PDTBuy It Now for only: $2,950.00Buy It Now | Add to watch list Biotech365 : NEW Thermo Invitrogen Qubit 4 DNA RNA Oligo Ion Protein Fluorometer w/Warranty BioMarketplace You want to propose your products or … Continue reading →
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Roivant joins RNA splicing push with Eisai deal
pharmaphorum
JANUARY 6, 2022
Roivant is the latest pharma group to take a position in the emerging field of therapies targeted at RNA splicing, licensing exclusive rights to a drug developed by a unit of Japanese drugmaker Eisai. . The post Roivant joins RNA splicing push with Eisai deal appeared first on.
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