FDA lifts hold on PTC Huntington’s disease trial
Bio Pharma Dive
JUNE 20, 2024
The agency has lifted a partial trial suspension based on one-year data showing PTC’s pill suppressed a key protein associated with the disorder.
Feinstein Institutes researchers discover new protein for sepsis treatment
Pharmaceutical Technology
FEBRUARY 6, 2023
Researchers at the Feinstein Institutes for Medical Research have discovered a new protein that can be a potential therapeutic target for lethal sepsis. Led by Feinstein Institutes researcher Haichao Wang, the new study focuses on detecting protein mediators that might contribute to uncontrolled immune responses to lethal infections.
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This Protein May Protect Against Alzheimer’s, Scientists Say
AuroBlog - Aurous Healthcare Clinical Trials blog
OCTOBER 16, 2023
In the search for a treatment for Alzheimer’s disease, researchers have zeroed in on a protein with protective effects. A new study reveals how cholesterol and inflammation in different types of human brain cells interact with a protein called ABCA7, which regulates how molecules pass through cell membranes.
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This Protein Could Help Us Unravel The Mystery of Alzheimer’s
AuroBlog - Aurous Healthcare Clinical Trials blog
MAY 28, 2024
The new research centers on the protein contactin-4 (CNTN4) – thought to play a role in neuronal network […] There are a lot of connected, moving biological parts in our brains, which makes the study of brain diseases particularly challenging.
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A Common Sleeping Pill May Reduce Buildup of Alzheimer’s Proteins, Study Finds
AuroBlog - Aurous Healthcare Clinical Trials blog
SEPTEMBER 8, 2024
In a study published in 2023, scientists found that using sleeping pills to get some shut-eye could reduce the build-up of toxic clumps of proteins […]
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Blocking a Single Protein Could Prevent Nerve Damage Responsible For Alzheimer’s
AuroBlog - Aurous Healthcare Clinical Trials blog
MARCH 10, 2024
Scientists have identified a key protein in the development of Alzheimer’s disease which could prove critical in slowing or even halting the condition’s progress.
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Flashing Lights And a Clicking Sound Cleared Toxic Proteins in Alzheimer’s Mice
AuroBlog - Aurous Healthcare Clinical Trials blog
MARCH 7, 2024
Scientists have now demonstrated how stimulating high-frequency brain waves in mice can clear out the amyloid protein clumps associated with Alzheimer’s. Could Alzheimer’s disease one day be treated by flashes of light and clicks of sound?
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A biotech shelves its Huntington's drugs after trial failures
Bio Pharma Dive
MARCH 30, 2021
Two drugs developed by Wave Life Sciences didn't appear to have an effect on disease-causing proteins, another setback for Huntington's research after disappointing results last week from Roche and Ionis.
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For The First Time, Scientists Capture The Protein-Lipid Dance on Video
AuroBlog - Aurous Healthcare Clinical Trials blog
APRIL 28, 2024
Our bodies are alive with activity and packed with proteins jammed into fatty membranes or floating in and out of watery cells. Scientists have now, for the first time, captured the dance between the two: a liquid tango featuring proteins and fats as they would normally move in cells.
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Sanofi drug for rare skin disease, acquired in buyout, fails in late-stage trial
Bio Pharma Dive
SEPTEMBER 9, 2021
The French drugmaker bought Principia Biopharma last year for two therapies that block a protein called BTK. The second targets a much bigger disorder, multiple sclerosis.
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Moderna reports ‘encouraging’ early data for one of its rare disease medicines
Bio Pharma Dive
MAY 19, 2023
The biotech, best known for its vaccine research, said its clinical trial is the first to report results of a messenger RNA therapeutic designed for intracellular protein replacement.
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Roche's closely watched immunotherapy fails key study in tough-to-treat lung cancer
Bio Pharma Dive
MARCH 30, 2022
A drug regimen including Roche's top prospect tiragolumab didn't outperform standard treatment in its first large trial, a setback for therapies aimed at a protein called TIGIT.
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WHO grants emergency use listing to SK bioscience’s SKYCovione
Pharmaceutical Technology
JUNE 20, 2023
Developed using pharmaceutical company GSK’s pandemic adjuvant, the vaccine targets the receptor-binding domain of the SARS-CoV-2 spike protein. The vaccine is based on recombinant protein vaccine technology and is suitable for storage between 2°C and 8°C.
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Eloxx repackages ELX-02 data in cystic fibrosis as it eyes pivotal trial
Pharmaceutical Technology
JUNE 15, 2023
Eloxx has revealed its lead candidate ELX-02 improved predicted forced expiratory volume (ppFEV1) in patients with Class 1 cystic fibrosis (CF) in a new analysis of a Phase II trial that missed its efficacy endpoints. The regimen in the trial was a one-week monotherapy period (1.5
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New Alzheimer’s Nasal Spray Clears Toxic Tangles in Human Neurons And Mice
AuroBlog - Aurous Healthcare Clinical Trials blog
JULY 15, 2024
Twisted and tangled proteins are found in the brains of many of those who die with Alzheimer’s disease. Some scientists suspect these neural knots can harm and even kill brain cells, but so far in clinical trials, drugs that have tried to target the tangles have shown limited success. A promising new medicine has now […]
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Vepdegestrant Hits Primary Endpoint in Phase III Breast Cancer Trial
XTalks
MARCH 11, 2025
Vepdegestrant, an investigational oral therapy, utilizes PROteolysis TArgeting Chimera (PROTAC) technology a mechanism that harnesses the bodys natural protein disposal system to selectively target and degrade the estrogen receptor.
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Alyftrek: Vertex Expands Cystic Fibrosis Treatment with Triple-Action Combo
XTalks
JANUARY 6, 2025
CF is a progressive genetic disease caused by defective CFTR proteins, which are crucial for regulating salt and water movement in cells. These mutations can vary in severity and impact on CFTR function, from complete protein dysfunction to defects in protein folding, trafficking or regulation.
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Kymera’s protein degrader starts Phase II trial in atopic dermatitis
Pharmaceutical Technology
DECEMBER 8, 2023
Following the dosing of the first patient in Phase II atopic dermatitis trial, Kymera received a $15m milestone payment from Sanofi.
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Aqilion and Merck partner to develop TAK1 protein inhibitors
Pharmaceutical Technology
FEBRUARY 16, 2023
Aqilion and Merck have entered an exclusive licence and strategic research partnership for the discovery, development and commercialisation of the transforming growth factor-β-activated kinase 1 (TAK1) protein-small molecule inhibitors. Merck will be responsible for leading the preclinical pharmacology and biology trials.
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Novavax starts first large-scale coronavirus vaccine trial in UK, as cases surge
Bio Pharma Dive
SEPTEMBER 25, 2020
The Maryland-based biotech is the first developer to advance a more traditional protein-based vaccine into the final stages of clinical testing.
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Surprise Alzheimer’s Finding: Brain’s Support Cells May Be Fueling Disease
AuroBlog - Aurous Healthcare Clinical Trials blog
AUGUST 22, 2024
Neurons aren’t the only brain cells producing the proteins associated with Alzheimer’s disease, a new study of mouse models reveals. Amyloid beta proteins occur naturally in our brains, but have long, and now controversially, been associated with Alzheimer’s disease. “Until now, neurons were […]
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Novavax’s Covid-19 vaccine gets Taiwan FDA EUA for use in adults
Pharmaceutical Technology
JUNE 24, 2022
The protein-based vaccine is engineered from the genetic sequence of the SARS-CoV-2 virus’ initial strain. Developed utilising Novavax’s recombinant nanoparticle technology to generate antigen obtained from the coronavirus spike (S) protein, the vaccine is also formulated with the company’s saponin-based Matrix-M adjuvant.
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Frontotemporal dementia: the state of treatment development
Pharmaceutical Technology
FEBRUARY 20, 2023
Different approaches that are studied include antisense oligonucleotides (ASOs), and gene therapies, which are in early clinical trials. This includes Denali Therapeutics whose treatment TAK-594/DNL593 is in a Phase I/II trial. This protein promotes lysosomal function. The trial features four cohorts.
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Pfizer takes COVID jab with ‘enhanced’ spike protein into phase 2
pharmaphorum
JULY 27, 2022
Pfizer and BioNTech have started a mid-stage trial of a new version of the COVID-19 vaccine based on a version of the spike protein that they hope will offer greater and broader protection against SARS-CoV-2 variants. The post Pfizer takes COVID jab with ‘enhanced’ spike protein into phase 2 appeared first on.
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China grants EUA to Covid-19 vaccine against XBB descendent lineages
Pharmaceutical Technology
JUNE 9, 2023
5+delta) protein vaccine (Sf9 cell). The subunit antigen in the vaccine has been based on the structure of the targeting S-RBD and HR proteins of the XBB and BA.5 It is self-assembled into stable trimeric protein particles with the addition of squalene-based oil-in-water emulsion adjuvant following purification and mixing.
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EC grants approval for Sanofi-GSK’s Covid-19 booster
Pharmaceutical Technology
NOVEMBER 11, 2022
The European Commission (EC) has granted approval for Sanofi and GSK ’s monovalent, recombinant-protein-based, adjuvanted Covid-19 vaccine, VidPrevtyn Beta, as a booster in adults aged 18 years and above. These trials comprised the Phase III VAT08 Stage 2 trial analysing initial efficacy and two other immunogenicity trials.
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Six Minutes of Intense Exercise Boosts a Crucial Molecule in Your Brain
AuroBlog - Aurous Healthcare Clinical Trials blog
JANUARY 23, 2023
Six minutes of high-intensity exercise is enough to produce a key protein in the brain, one that’s important in brain formation, function, and memory, and which has been implicated in the progress of neurodegenerative disorders such as Alzheimer’s disease.
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Arvinas gets positive breast cancer data, but finds differentiation a hard sell
Bio Pharma Dive
MARCH 11, 2025
Trial results show vepdegestrant, a protein-degrading drug Arvinas is developing with Pfizer, improved on fulvestrant in a subgroup of breast cancer patients, but not the overall study population.
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Obicetrapib Lowers LDL-C as Monotherapy and with Ezetimibe in Phase III Trials
XTalks
DECEMBER 26, 2024
Menarini Group has announced positive topline data from the Phase III BROADWAY and TANDEM clinical trials, evaluating obicetrapib and the fixed-dose combination of obicetrapib with ezetimibe. Meanwhile, the TANDEM trial evaluated a fixed-dose combination of obicetrapib with 10 mg ezetimibe in a similar patient population.
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Breakthrough: Rare Gene Mutation Offers Clues to Preventing Type 1 Diabetes
AuroBlog - Aurous Healthcare Clinical Trials blog
APRIL 29, 2024
The mutation is in the gene for a protein called programmed death-ligand 1 (PD-L1), and a […] A unique genetic mutation in two siblings – that has never been seen in anyone else – has been discovered by UK researchers at the University of Exeter, pointing the way towards new treatment options for type 1 diabetes.
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Radical Vaccine Strategy Could Help Quash Parasite Afflicting Millions
AuroBlog - Aurous Healthcare Clinical Trials blog
APRIL 11, 2024
Using viruses that infect bacteria to detect proteins sprouted by a notorious parasite, scientists have honed in on possible vaccine targets for schistosomiasis, a neglected tropical disease that currently affects an estimated 600 million people worldwide, causing 280,000 deaths per year.
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AstraZeneca study points to new uses for targeted cancer drug Enhertu
Bio Pharma Dive
JUNE 5, 2023
Results from a “basket” trial of the antibody-drug conjugate show it shrank tumors across a half dozen cancers, suggesting a broader role to targeting the protein HER2.
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Mice That Eat Less Live Longer – And We May Finally Know Why
AuroBlog - Aurous Healthcare Clinical Trials blog
JULY 24, 2024
We’ve known for over a century that mice and rats live longer when they are fed less, but a new study reveals the secret might be an imbalance between energy consumed and burned, rather than a lack of energy or protein. Researchers from the US and UK studied groups of mice put on identical diets, […]
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How did pharma develop a vaccine so quickly?
World of DTC Marketing
DECEMBER 29, 2020
Once introduced into the human body, the protein-making machinery uses this genetic material in our cells to churn out the coronavirus “spike protein,” triggering an immune response. Another consideration is that while in traditional vaccine development, clinical trials are carried out in sequence. Then there are the finances.
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No drugs for prions: could new approaches alleviate therapeutic scarcity?
Pharmaceutical Technology
AUGUST 5, 2022
As per the prevailing prion theory, a misfolded version of a normal cell-surface protein acts as the chief infectious agent. According to GlobalData’s Pharma Intelligence Center, there are only six drugs in active development for CJD, of which only one has been in clinical trials. And then comes the question of the right target.
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Health Canada approves Novavax’s Covid-19 vaccine for adolescents
Pharmaceutical Technology
DECEMBER 7, 2022
Health Canada has granted approval for a supplement to a New Drug Submission (sNDS) of Novavax ’s Covid-19 vaccine (Recombinant protein, Adjuvanted), Nuvaxovid (NVX-CoV2373), for use in adolescents aged 12 to 17 years. The trial is designed to analyse the safety and effectiveness of the vaccine.
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Your Body’s Internal Clock May Boost Cancer Treatments, Scientists Say
AuroBlog - Aurous Healthcare Clinical Trials blog
JUNE 19, 2024
link] Checkpoint inhibitors are immunotherapy drugs that block crucial proteins from binding to cancerous tumors, meaning the immune system’s T cells can more easily […]
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The Hidden Cause of Alzheimer’s May Have Been Identified a Century Ago
AuroBlog - Aurous Healthcare Clinical Trials blog
APRIL 2, 2024
Alzheimer’s disease is commonly associated with clumps and tangles of proteins building up in brain cells. Yet for more than a century, accumulations of a completely different material have also been linked with the neurodegenerative condition.
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US FDA grants Fast Track status for Avidity’s AOC 1020 to treat FSHD
Pharmaceutical Technology
JANUARY 19, 2023
This DUX4 protein abnormal expression leads to modifications in gene expression in muscle cells which are associated with progressive muscle function loss in FSHD patients. Avidity Biosciences’ AOC 1020 is intended to reduce the DUX4 mRNA and DUX4 protein expression in muscles in these patients.
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Cheap Daily Supplement Seems to Boost Brain Function in Older Adults
AuroBlog - Aurous Healthcare Clinical Trials blog
MARCH 5, 2024
The first twin study of its kind suggests that taking daily protein and prebiotic supplements can improve scores on memory tests in people over the age of 60. What’s good for your aging gut may also be good for your aging brain. The findings are food for thought, especially as the same visual memory and […]
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How Old Are Your Eyes? New ‘Clock’ Could Reveal Disease Risk
AuroBlog - Aurous Healthcare Clinical Trials blog
NOVEMBER 1, 2023
Almost 6,000 proteins detected in the fluid could be traced […] Scientists have developed a new tool for determining the age of eye cells without sampling regenerative tissue, which could make treatments for eye disease more personalized and better targeted.
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A Type of Fiber Could Have Weight Loss Benefits Similar to Ozempic
AuroBlog - Aurous Healthcare Clinical Trials blog
FEBRUARY 5, 2025
(courtneyk/Getty Images) Research on the gut microbiome has triggered a ‘revolution‘ in nutritional science, and in the last few years, dietary fiber has become the “new protein” added to foods in abundance to feed our gut and boost our health.
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Scientists Discover a New, Unexpected Way That Cancer Cells Spread
AuroBlog - Aurous Healthcare Clinical Trials blog
JULY 30, 2023
Key to this newly discovered process is GRP78, and it’s what’s known as a chaperone protein. One of the challenges in treating cancer is stopping it from metastasizing, and a new study reveals one of the fundamental mechanisms through which this happens. Now we know about this mechanism, perhaps we can stop it.
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