pharmaphorum

OCTOBER 18, 2021

SMi Group’s 13th Annual Conference: RNA Therapeutics 2022. Bolstering the latest advances and opportunities in RNA-based medicine. BENEFITS OF ATTENDING: •Explore how mRNA vaccines have led the way in the response against COVID-19 and key takeaways for the industry. 9th – 10th February 2022. London, UK. Hashtag: #SMiRNA.

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pharmaphorum

NOVEMBER 9, 2020

As the death toll from COVID19 inexorably mounts, Pfizer and BioNTech have announced that their COVID-19 vaccine candidate is more than 90% effective at countering the disease in an interim analysis. This means that protection is achieved 28 days after the initiation of the vaccination, which consists of a 2-dose schedule.

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Vaccine Vaccination Clinical Trials Clinical Trials 98

Pharmaceutical Technology

JUNE 27, 2022

While some countries are making progress in eliminating hepatitis C, many remain challenged in reaching those affected, Dr Philippa Easterbrook, Senior Scientist at WHO’s Department of Global HIV, Hepatitis and Sexually Transmitted Infections Programmes, tells Pharmaceutical Technology.

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RNA Vaccination Vaccine Scientist 264

Scienmag

MAY 3, 2021

Researchers who elucidated key functions of RNA, the workhorse molecule of cells, will be honored in October The 2021 Warren Alpert Foundation Prize has been awarded to scientists Lynne Maquat and Joan Steitz for seminal discoveries in the biology and function of RNA, the workhorse molecule of cells.

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RNA Scientist Research Allergies 41

STAT News

OCTOBER 21, 2022

Thirty years ago, Katalin Karikó had what was then an outlandish idea: use messenger RNA as a medicine. One rejection she might now be able to laugh about was a research opportunity with funding for six scientists. But getting funding to demonstrate that might be possible was impossible, despite three decades of trying.

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Research RNA Scientist Vaccination 98

pharmaphorum

NOVEMBER 25, 2020

AstraZeneca’s research chief has said that the more effective dosing regimen of its coronavirus vaccine was discovered by accident. According to Reuters , the AstraZeneca development team made a minor mistake that made them realise they could significantly boost the success rate of the vaccine, codenamed AZD1222.

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pharmaphorum

NOVEMBER 10, 2021

After being hailed as a triumph of public-private drug development, Moderna’s partnership with the US government on its COVID-19 vaccine looks like it may descend into acrimony. The patent has been filed but not yet awarded.

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XTalks

OCTOBER 21, 2020

The answer may lie in the genetic code of the virus, which scientists at Duke University have found contains several silent mutations that affect protein folding. Moreover, Berrio says the changes likely affected the folding and function of viral RNA. These mutations may thus be “silent” as they do not alter protein structure.

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XTalks

OCTOBER 8, 2024

The 2024 Nobel Prize in Physiology or Medicine has been awarded to American scientists Victor Ambros and Gary Ruvkun for their groundbreaking discovery of microRNA (or miRNA) and its role in post-transcriptional gene regulation. Their ability to modulate gene expression at the RNA level provides a novel therapeutic approach for conditions.

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Regulation Genetics Scientist RNA 52

Scienmag

SEPTEMBER 30, 2020

Scientists are fighting back with multiple strategies, including vaccines, repurposed drugs developed for other diseases and brand-new therapies. Now, researchers reporting in ACS Central Science have identified small molecules that target a structure within the RNA genome […].

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pharmaphorum

DECEMBER 21, 2020

Moderna and BioNTech, two rising stars in biotech, were in the limelight this year with their pioneering mRNA vaccines against COVID-19. But the tragic events of 2020 have meant these companies have become household names as their trailblazing mRNA vaccines became the first to be approved by regulators against the COVID-19 scourge.

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pharmaphorum

JANUARY 22, 2021

So far, neither variant seems to be associated with more severe COVID-19 symptoms, although there has been some preliminary research suggesting the SA strain could allow reinfection with SARS-CoV-2, and also be less susceptible to vaccines.

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Scienmag

FEBRUARY 17, 2021

Messenger RNA (mRNA) vaccines to prevent COVID-19 have made headlines around the world recently, but scientists have also been working on mRNA vaccines to treat or prevent other diseases, including some forms of cancer.

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pharmaphorum

JANUARY 26, 2023

A 2022 study from the Royal College of Physicians and British Pharmacological Society demonstrated the potential of pharmacogenomics, with scientists identifying the genetic cause behind an individual’s drug response for over forty medicines. Just one mutation can lead to a complete change in protein formation.

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The Pharma Data

JANUARY 22, 2021

As research developments into RNA vaccines help scientists accelerate drug candidates to arm the immune system against coronavirus, Pharma IQ ’s Keeping tabs on Covid-19 update returns with news from some of the biotechnology innovators leading the fight against the global pandemic.

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Vaccine Vaccination Protein Immune Response 52

pharmaphorum

FEBRUARY 8, 2021

The UK has agreed a 50 million-dose order for a COVID-19 vaccine with German biotech CureVac to support development of a shot that specifically targets emerging variants of the virus. AZ has said it is confident however that it could quickly update its vaccine and have a new version ready for the autumn.

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The Pharma Data

JANUARY 21, 2021

22, 2021 — Everyone has heard the scary reports about the new, more infectious coronavirus variants that are circulating in countries around the world, but scientists aren’t pushing the panic button at this point. Because the new COVID-19 vaccines should still work on these viral interlopers. FRIDAY, Jan.

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Vaccine Vaccination Protein Immune Response 52

The Pharma Data

AUGUST 16, 2021

The study assessed cynomolgus macaques vaccinated with 12µg of either the first or second-generation vaccine candidate. During challenge with the original SARS-CoV-2 virus, animals vaccinated with CV2CoV were found to be better protected based on highly effective clearance of the virus in the lungs and nasal passages.

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pharmaphorum

MAY 17, 2022

Expect exclusive data from the movers and shakers in mRNA vaccine and therapy development, 75+ world-class speakers, 5 dedicated tracks of content, and 45+ deep-dive case studies. Rituparna Das, VP – COVID Vaccines, Moderna. Pervin Anklesaria, Deputy Director, HIV Vaccines & Biologics, Bill & Melinda Gates Foundation.

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Vaccine Vaccination RNA Scientist 52

The Pharma Data

NOVEMBER 16, 2020

November 16, 2020 — An independent data and safety monitoring board (DSMB) overseeing the Phase 3 trial of the investigational COVID-19 vaccine known as mRNA-1273 reviewed trial data and shared its interim analysis with the trial oversight group on Nov. The interim analysis comprised 95 cases of symptomatic COVID-19 among volunteers.

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Clinical Trials Clinical Trials Vaccine Vaccination 52

The Pharma Data

DECEMBER 18, 2020

Action Follows Thorough Evaluation of Available Safety, Effectiveness, and Manufacturing Quality Information by FDA Career Scientists, Input from Independent Experts. The emergency use authorization allows the Moderna COVID-19 Vaccine to be distributed in the U.S. SILVER SPRING, Md. , 18, 2020 /PRNewswire/ — Today, the U.S.

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The Pharma Data

JULY 6, 2021

But HIV’s ability to mutate isn’t unique among RNA viruses – most viruses develop mutations, or changes in their genetic code, over time. He and his team reasoned that the virus would likely mutate, potentially in ways that would allow it to escape both natural and vaccine-induced immunity.

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Vaccine Vaccination Research Immune Response 52

pharmaphorum

JANUARY 20, 2021

UK biotech ConserV Bioscience has joined with California’s Lawrence Livermore National Laboratory to develop broad-spectrum coronavirus vaccines as concerns mount over potentially more infectious strains emerging in the UK, South Africa and Brazil. Feature image courtesy of Rocky Mountain Laboratories/NIH.

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Vaccine Vaccination Protein RNA 52

The Pharma Data

JANUARY 13, 2021

13, 2021 — A single-shot COVID-19 vaccine from Johnson & Johnson has shown very strong results in early clinical trials, potentially providing a significant boost to U.S. vaccination efforts. The new vaccine remains stable for a time in the refrigerator. WEDNESDAY, Jan. 13 in the New England Journal of Medicine.

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XTalks

MARCH 8, 2022

From leading COVID-19 vaccine developments to being at the helm of the latest gene therapies and inventing ground-breaking DNA technologies like CRISPR, women have been at the forefront of some of the most leading-edge scientific discoveries in recent years, both as innovators and leaders.

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Life Science Gene Therapy DNA Vaccination 105

NY Times

JANUARY 26, 2021

Scientists are exploring the physics of viruses, to understand how these pathogens assemble themselves — and might be rent apart.

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Pharmaceutical Technology

OCTOBER 28, 2022

They inform industrial scientists what is necessary to ensure that their product meets the safety and efficacy requirements to get a product approved in humans. For example, the Covid-19 pandemic brought messenger ribonucleic acid (mRNA) vaccines into international prominence. For more information, please download our white paper.

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pharmaphorum

NOVEMBER 24, 2021

Taking place in-person in Berlin, Germany on 25 – 27 January 2022 , this is your roadmap to expanding the therapeutic applicability of mRNA- based drugs and vaccines. Here’s a snapshot of our world class speaker line-up: Andreas Kuhn, Senior VP – RNA Biochemistry & Manufacturing, BioNTech .

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Vaccine Vaccination Gene Therapy RNA 52

XTalks

AUGUST 18, 2020

An important feature of the test that contributes to its reduced cost is the fact that sample processing does not require a separate nucleic acid (RNA) extraction step. This is significant because shortages of RNA extraction kits have been a recurrent issue since the beginning of the pandemic.

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Worldwide Clinical Trials

MAY 30, 2024

This approach is facilitated by developing ASOs and RNA interference (RNAi) therapies, which target the various molecular and genetic mechanisms contributing to ALS pathophysiology and disease progression. However, work is needed before CRISPR-mediated treatments become possible, including a better understanding of the genes involved in ALS.

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Gene Clinical Trials Clinical Trials Gene Therapy 204

Roots Analysis

AUGUST 23, 2024

Vaccinations in the past have always been either weak or inactive forms of a pathogen which was given to the body so that our immune system is trained to recognize that given pathogen. There are several advantages to approaching vaccination this way. This alone makes them much safer than most conventional vaccines on the market today.

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Protein Vaccine Vaccination Immune Response 40

Roots Analysis

MAY 21, 2024

Advantages of Lipid Nanoparticle LNPs are gaining significant attention of formulation scientists in drug delivery due to the various advantages offered by them. Gene Therapies: LNPs have the ability to effectively deliver nucleic acids, including small interfering RNA (siRNA), messenger RNA (mRNA), and plasmid DNA to the target cells.

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The Pharma Data

DECEMBER 3, 2020

Significant differences among COVID-19 diagnostic tests are resulting in inaccurate results that sometimes put populations at risk or quarantine people needlessly, contributing to skepticism about pronouncements from scientists and public health authorities. Advantages include sensitivity, better limit of detection, and miniaturization.

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RNA Protein DNA Antibody 52

The Pharma Data

MARCH 8, 2022

The ongoing SARS-CoV-2 pandemic has caused an imminent urge for both antiviral therapeutical drugs and vaccines. While the development of vaccines was accomplished in a remarkably short timeframe, the identification of direct antiviral treatments has progressed comparatively slowly. Camouflage protects virus from immune system.

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Immune Response RNA Protein Genetics 52

The Pharma Data

NOVEMBER 1, 2021

Lydia Kavraki, a computer scientist at the George R. The project, detailed in an open-access paper in Computers in Biology and Medicine, incorporates models of three drug targets – main protease (Mpro), RNA-dependent RNA polymerase (RdRp) and Papain-like protease (PLpro) – for ensemble docking through DINC-COVID.

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Drugs Protein Engineer RNA 52

Druggist

SEPTEMBER 2, 2021

Researchers continue to praise its efficacy in combating single strand RNA viruses including SARS-CoV-2. Researchers also praise its efficiency in combating anti-virus belonging to single-strand RNA viruses, including SARS-CoV-2. What does the research say about this? How does Ivermectin work?

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RNA Medicine Drugs Research 52

pharmaphorum

FEBRUARY 3, 2021

Dr Jennifer Harbottle, senior scientist in the R&D Base Editing team of PerkinElmer’s Horizon Discovery business, looks at progress made in the realms of biotechnology and next-generation diagnostics, vaccines and therapeutics, including the application of CRISPR-Cas9 gene editing in developing and refining cell therapies.

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